Correlation of increased azithromycin concentrations with phagocyte infiltration into sites of localized infection

Journal of Antimicrobial Chemotherapy

Volumn 37, Issue SUPPL. C, 1996, Pages 9-19

  Girard, A E ^a   Cimochowski, C R ^a   Faiella, J A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; MACROLIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CELL INFILTRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; DRUG TRANSPORT; FEMALE; GERBIL; HAEMOPHILUS INFLUENZAE; HOST CELL; INFECTION; INFLAMMATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; OTITIS MEDIA; PHAGOCYTE; PNEUMONIA; PROVOCATION TEST; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

EID: 0029812509     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/37.suppl_c.9     Document Type: Article

References (15)

1. Azoulay-Dupuis, E., Bedos, J.-P., Vallée, E., Hardy, D. J., Swanson, R. N. & Pocidalo, J.-J. (1991a). Antipneumococcal activity of ciprofloxacin, ofloxacin, and temafloxacin in an experimental mouse pneumonia model at various stages of disease. Journal of Infectious Diseases 163, 319-24.
2. Azoulay-Dupuis, E., Vallée, E., Bedos, J.-P., Muffat-Joly, M. & Pocidalo, J.-J. (1991b). Prophylactic and therapeutic activities of azithromycin in a mouse model of a pneumococcal pneumonia. Antimicrobial Agents and Chemotherapy 35, 1024-8.
3. Baldwin, D. R., Wise, R., Andrews, J. M., Ashby, J. P. & Honeybourne, D. (1990). Azithromycin concentrations at the sites of pulmonary infection. European Respiratory Journal 3, 886-90.
4. Ballow, C. H., Amsden, G. W., Highet, V. S. & Forrest, A. (1995). Concentration of azithromycin (A) in polymorphonuclear leukocytes (PMNs): role in tissue delivery. Canadian Journal of Infectious Diseases 6, Suppl. C, 255 (Abstract 0425).
5. Esposito, A. L. & Pennington, J. E. (1983). Effects of aging on antibacterial mechanisms in experimental pneumonia. American Review of Respiratory Disease 128, 662-7.
6. Freeman, C. D., Nightingale, C. H., Nicolau, D. P., Belliveau, P. P., Banevicius, M. A. & Quintiliani, R. (1994). Intracellular and extracellular penetration of azithromycin into inflammatory and noninflammatory blister fluid. Antimicrobial Agents and Chemotherapy 38, 2449-51.
7. Girard, A. E., Cimochowski, C. R., Faiella, J. A. & Girard, D. (1990). Correlation of increased azithromycin levels with phagocyte infiltration into sites of infection. In Program and Abstracts of the Thirtieth Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta, GA, 1990. Abstract 762, p. 213. American Society for Microbiology, Washington, DC.
8. Girard, A. E., Faiella, J. A. & Cimochowski, C. R. (1991). The unique pharmacokinetics of azithromycin in models of localized infection. In Abstracts of the Fifth European Congress of Clinical Microbiology and Infectious Diseases, Oslo, Norway, 1991. Abstract 1754, p. 192. European Society of Clinical Microbiology and Infectious Diseases.
9. Girard, A. E., Girard, D., English, A. R., Gootz, T. D., Cimochowski, C. R., Faiella, J. A. et al. (1987). Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Antimicrobial Agents and Chemotherapy 31, 1948-54.
10. Gladue, R. P., Bright, G. M., Isaacson, R. E. & Newborg, M. F. (1989). In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrobial Agents and Chemotherapy 33, 277-82.
11. Pukander, J. (1994). Penetration of azithromycin into middle ear effusion in acute and secretory otitis media in children. In Program and Abstracts of the Second International Conference on the Macrolides, Azalides and Streptogramins, Venice, 1994. Abstract 199, p. 42. Wallace Communications, Atlanta, GA.
12. Shepard, R. M. & Gregoire, J. A. (1990). Pharmacokinetics of azithromycin in leukocytes of dogs and rats. In Program and Abstracts of the Sixth International Congress for Infectious Diseases, Montreal, 1990. Abstract 157, p. 173. International Society for Infectious Diseases.
13. Simon, H. J., & Yin, E. J. (1970). Microbioassay of antimicrobial agents. Applied Microbiology 19, 573-9.
14. Vallée, E., Azoulay-Dupuis, E., Pocidalo, J.-J. & Bergogne-Bérézin, E. (1992). Activity and local delivery of azithromycin in a mouse model of Haemophilus influenzae lung infection. Antimicrobial Agents and Chemotherapy 36, 1412-7.
15. Wildfeuer, A., Laufen, H., Müller-Wening, D. & Haferkamp, O. (1989). Interaction of azithromycin and human phagocytic cells: uptake of the antibiotic and the effect on the survival of ingested bacteria in phagocytes. Arzneimittel-Forschung 39, 755-8.