Obesity is a risk factor for early pregnancy loss after IVF or ICSI

Acta Obstetricia et Gynecologica Scandinavica

Volumn 79, Issue 1, 2000, Pages 43-48

  Fedorcsák, Péter ^a,b   Storeng, Ritsa ^a,c   Dale, Per Olav ^a   Tanbo, Tom ^a   Åbyholm, Thomas ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

In vitro fertilization; Intracytoplasmic sperm injection; Obesity; Spontaneous abortion

Indexed keywords

CLOMIFENE CITRATE; FOLLITROPIN; GONADORELIN ANTAGONIST; HUMAN MENOPAUSAL GONADOTROPIN; PROGESTERONE;

ADULT; AGE; ARTICLE; BIRTH RATE; BODY MASS; CELL COUNT; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FERTILIZATION IN VITRO; FETUS ECHOGRAPHY; HUMAN; INFERTILITY; INTRACYTOPLASMIC SPERM INJECTION; LUTEAL PHASE; MAJOR CLINICAL STUDY; NORMAL HUMAN; OBESITY; OOCYTE; OVARY POLYCYSTIC DISEASE; PREGNANCY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; REGRESSION ANALYSIS; RISK FACTOR; SPONTANEOUS ABORTION;

ABORTION, SPONTANEOUS; ADULT; ANALYSIS OF VARIANCE; FEMALE; FERTILIZATION IN VITRO; HUMANS; LOGISTIC MODELS; OBESITY; PREGNANCY; PREGNANCY COMPLICATIONS; RISK FACTORS; SPERM INJECTIONS, INTRACYTOPLASMIC;

EID: 0033987893     PISSN: 00016349     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0412.2000.079001043.x     Document Type: Article

References (33)

1. 1. Zaadstra BM, Seidell JC, Van Noord PA, te Velde ER, Habbema JD, Vrieswijk B et al. Fat and female fecundity: prospective study of effect of body fat distribution on conception rates. BMJ 1993; 306: 484-7.
2. 2. Wass P, Waldenstrom U, Rossner S, Hellberg D. An android body fat distribution in females impairs the pregnancy rate of in-vitro fertilization-embryo transfer. Hum Reprod 1997; 12: 2057-60.
3. 3. Green BB, Weiss NS, Daling JR. Risk of ovulatory infertility in relation to body weight. Fertil Steril 1988; 50: 721-6.
4. 4. Hartz AJ, Barboriak PN, Wong A, Katayama KP, Rimm AA, Kalkhoff R et al. The association of obesity with infertility and related menstrual abnormalities in women. A study of factors associated with the ability to maintain weight loss. Int J Obes 1979; 8: 471-83.
5. 5. Dale PO, Tanbo T, Haug E, Åbyholm T. The impact of insulin resistance on the outcome of ovulation induction with low-dose follicle stimulating hormone in women with polycystic ovary syndrome. Hum Reprod 1998; 13: 567-70.
6. 6. Hamilton-Fairley D, Kiddy D, Watson H, Paterson C, Franks S. Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonadotrophin. Br J Obstet Gynaecol 1992; 99: 128-31.
7. 7. Homburg R, Armar NA, Eshel A, Adams J, Jacobs HS. Influence of serum luteinising hormone concentrations on ovulation, conception, and early pregnancy loss in polycystic ovary syndrome. BMJ 1988; 297: 1024-6.
8. 8. Homburg R, Levy T, Berkovitz D, Farchi J, Feldberg D, Ashkenazi J et al. Gonadotropin-releasing hormone agonist reduces the miscarriage rate for pregnancies achieved in women with polycystic ovarian syndrome. Fertil Steril 1993; 59: 527-31.
9. 9. Tarlatzis BC, Grimbizis G. The significance of high follicular-phase luteinizing hormone levels in the treatment of women with polycystic ovarian syndrome by in vitro fertilization. J Assist Reprod Genet 1997; 14: 1-4.
10. 10. Dale PO, Tanbo T, Vaaler S, Åbyholm T. Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations. Fertil Steril 1992; 58: 487-91.
11. 11. Smith SR. The endocrinology of obesity. Endocrinol Metab Clin North Am 1996; 25: 921-42.
12. 12. Tanbo T, Kjekshus E, Dale PO, Storeng R, Lunde O, Magnus Ø et al. Intracytoplasmatic spermieinjeksjon. [Intracytoplasmic sperm injection]. (in Norwegian with English abstract). Tidsskr Nor Laegeforen 1998; 118: 864-9.
13. 13. Åbyholm T, Tanbo T, Dale PO, Kjekshus E, Magnus Ø. The first attempt at IVF treatment. Results and requirements for a satisfactory success rate. Eur J Obstet Gynecol Reprod Biol 1991; 38: 125-32.
14. 14. Mills CL. Factors affecting embryological parameteres and embryo selection for IVF-ET. In: Brinsden PR, Rainsbury PA, eds. A textbook of in vitro fertilization and assisted reproduction. Carnforth: Parthenon, 1992; 187-204.
15. 15. Risch HA, Weiss NS, Clarke EA, Miller AB. Risk factors for spontaneous abortion and its recurrence. Am J Epidemiol 1988; 128: 420-30.
16. 16. Groll M. Endometriosis and spontaneous abortion. Fertil Steril 1984; 41: 933-5.
17. 17. Jansen RP. Spontaneous abortion incidence in the treatment of infertility. Am J Obstet Gynecol 1982; 143: 451-73.
18. 18. Fedele L, Bianchi S. Habitual abortion: endocrinological aspects. Curr Opin Obstet Gynecol 1995; 7: 351-6.
19. 19. Holte J, Bergh T, Gennarelli G, Wide L. The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in pre-menopausal women. Clin Endocrinol (Oxf) 1994; 41: 473-81.
20. 20. Zhang H, Bracken MB. Tree-based, two-stage risk factor analysis for spontaneous abortion. Am J Epidemiol 1996; 144: 989-96.
21. 21. Hollmann M, Runnebaum B, Gerhard I. Effects of weight loss on the hormonal profile in obese, infertile women. Hum Reprod 1996; 11: 1884-91.
22. 22. Clark AM, Thornley B, Tomlinson L, Galletley C, Norman RJ. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod 1998; 13: 1502-5.
23. 23. Pellestor F, Girardet A, Andreo B, Arnal F, Humeau C. Relationship between morphology and chromosomal constitution in human preimplantation embryo. Mol Reprod Dev 1994; 39: 141-6.
24. 24. Richards JS. Hormonal control of gene expression in the ovary. Endocr Rev 1994; 15: 725-51.
25. 25. Poretsky L, Piper B. Insulin resistance, hypersecretion of LH, and a dual-defect hypothesis for the pathogenesis of polycystic ovary syndrome. Obstet Gynecol 1994; 84: 613-21.
26. 26. Auwerx J, Staels B. Leptin. Lancet 1998; 351: 737-42.
27. 27. Karlsson C, Lindell K, Svensson E, Bergh C, Lind P, Billig H et al. Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab 1997; 82: 4144-8.
28. 28. Cioffi JA, Van Blerkom J, Antczak M, Shafer A, Wittmer S, Snodgrass HR. The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod 1997; 3: 467-72.
29. 29. Cano F, Garcia-Velasco JA, Millet A, Remohi J, Simon C, Pellicer A. Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women. J Assist Reprod Genet 1997; 14: 254-61.
30. 30. Katagiri S, Moon YS, Yuen BH. The role for the uterine insulin-like growth factor I in early embryonic loss after superovulation in the rat. Fertil Steril 1996; 65: 426-36.
31. 31. Ertzeid G, Storeng R, Lyberg T. Treatment with gonadotropins impaired implantation and fetal development in mice. J Assist Reprod Genet 1993; 10: 286-91.
32. 32. Ertzeid G, Storeng R. Adverse effects of gonadotrophin treatment on pre-and postimplantation development in mice. J Reprod Fertil 1992; 96: 649-55.
33. 33. Fridström M, Sjöblom P, Pousette A, Hillensjö T. Serum FSH levels in women with polycystic ovary syndrome during ovulation induction using down-regulation and urofollitropin. Eur J Endocrinol 1997; 136: 488-92.