Low plasma folate in combination with the 677 C→T methylenetetrahydrofolate reductase polymorphism is associated with increased risk of coronary artery disease in Koreans

Thrombosis Research

Volumn 97, Issue 2, 2000, Pages 77-84

  Yoo, Jun Hyun ^a   Park, Sang Chul ^b  

^a Samsung Medical Center   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Coronary artery disease; Folate; Gene; Homocysteine; Methylenetetrahydrofolate reductase

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; HOMOCYSTEINE;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; FOLIC ACID BLOOD LEVEL; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERHOMOCYSTEINEMIA; KOREA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CORONARY DISEASE; FEMALE; FOLIC ACID; GENE FREQUENCY; HEART CATHETERIZATION; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; KOREA; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTATION, MISSENSE; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYMORPHISM, GENETIC; RISK FACTORS; SEX FACTORS; VITAMIN B 12;

EID: 0033987711     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(99)00127-9     Document Type: Article

References (25)

1. Kang S.-S., Wong P.W.K. Genetic and nongenetic factors for moderate hyperhomocyst(e)inemia. Atherosclerosis. 119:1996;135-138.
2. Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., Boers G.J.H., Den Heijer M., Kluijtmans L.A.J., Van den Heuvel L.P., Rozen R. A candidate genetic risk factor for vascular disease. A common mutation in methylenetetrahydrofolate reductase Nat Genet. 10:1995;111-113.
3. Gallagher P.M., Meleady R., Shields D.C., Tan K.S., McMaster D., Rosen R., Evans A., Graham I.M., Whitehead A.S. Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation Circulation. 94:1996;2154-2158.
4. Kluijtmans L.A.J., Den Heuvel L.P.W.J., Boers G.H.J., Frosst P., Stevens E.M.B., Van Oost B.A., Den Heijer M., Trijbels F.J.M., Rozen R., Blom H.J. Molecular genetic analysis in mild hyperhomocysteinemia. A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease Am J Hum Genet. 58:1996;35-41.
5. Morita H., Taguhi J.I., Kurihara H., Kitaoka M., Kaneda H., Kurihara Y., Maemura K., Shindo T., Minamino T., Ohno M., Yamaoki K., Ogasawara K., Aizawa T., Suzuki S., Yazaki Y. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation. 95:1997;2032-2036.
6. Ou T., Yamakawa-Kobayashi K., Arinami T., Amemiya H., Fujiwara H., Kawata K., Saito M., Kikuchi S., Noguchi Y., Sugishita Y., Hamaguchi H. Methylenetetrahydrofolate reductase and apolipoprotein E polymorphism are independent risk factors for coronary heart disease in Japanese. A case-control study Atherosclerosis. 137:1998;23-28.
7. Adams M., Smith P.D., Martin D., Thompson J.R., Lodwick D., Samani N.J. Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction. Q J Med. 89:1996;437-444.
8. Wilcken D.E.L., Wang X.L., Sim A.S., McCredie M. Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation. Arterioscler Thromb Vasc Biol. 16:1996;878-882.
9. Schmitz C., Lindpaintner K., Verhoef P., Gaziano J.M., Buring J. Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. Circulation. 94:1996;1812-1814.
10. van Bockxmeer F.M., Mamotte C.D.S., Vasikaran S.D., Taylor R.R. Methylenetetrahydrofolate reductase gene and coronary artery disease. Circulation. 95:1997;21-23.
11. Brugada R., Marian A.J. A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction. Atherosclerosis. 128:1997;107-112.
12. Verhoef P., Kok F.J., Kluijtmans L.A.J., Blom H.J., Refsum H., Ueland P.M., Kruyssen D.A.C.M. The 677 CT mutation in the methylenetetrahydrofolate reductase gene. Associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease Atherosclerosis. 132:1997;105-113.
13. Anderson J.L., King G.J., Thomson M.J., Todd M., Bail T.L., Muhlestein J.B., Carlquist J.F. A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction. J Am Coll Cardiol. 30:1997;1206-1211.
14. Yoo J.-H., Hong S.B. A common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants. Metabolism. 48:1999;1047-1051.
15. Jacques P.F., Bostom A.G., Williams R.R., Ellison R.C., Eckfeldt J.H., Rosenberg I.H., Selhub J., Rosen R. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 93:1996;7-9.
16. Ma J., Stampfer M.J., Hennekens C.H., Frosst P., Selhub J., Horsford J., Malinow M.R., Willett W.C., Rozen R. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation. 94:1996;2410-2416.
17. Christensen B., Frosst P., Lussier-Cacan S., Selhub J., Goyette P., Rosenblatt D.S., Genest J., Rosen R. Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease. Arterioscler Thomb Vasc Biol. 17:1997;569-573.
18. Rosen R. Genetic predisposition to hyperhomocysteinemia. Deficiency of methylenetetrahydrofolate reductase (MTHFR) Thromb Haemost. 78:1997;523-526.
19. Brattström L., Wilcken D.E.L., Öhrvik J., Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease. The result of a meta-analysis Circulation. 98:1998;2520-2526.
20. Yoo J.-H., Park J.-E., Hong K.-P., Lee S.-H., Kim D.-K., Lee W.-R., Park S.-C. Moderate hyperhomocyst(e)inemia is associated with the presence of coronary artery disease and the severity of coronary atherosclerosis in Koreans. Thromb Res. 94:1999;45-52.
21. Vester B., Rasmussen K. High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur J Clin Chem Clin Biochem. 29:1991;549-554.
22. Durand P., Lussier-Cacan S., Blache D. Acute methionine load-induced hyperhomocysteinenmia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats. FASEB J. 11:1997;1157-1168.
23. Morrison H.I., Schaubel D., Desmeules M., Wigle D.T. Serum folate and risk of fatal coronary heart disease. JAMA. 275:1996;1893-1896.
24. Giles W.H., Kittner S.J., Croft J.B., Anda R.F., Casfer M.L., Ford E.S. Serum folate and risk for coronary heart disease. Result from a cohort of US adults Ann Epidemiol. 8:1998;490-496.
25. Malinow M.R., Nieto F.J., Kruger W.D., Duell P.B., Hess D.L., Gluckman R.A., Block P.C., Holzkang C.R., Anderson P.H., Seltzer D., Upson B., Lin Q.R. The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Arterioscler Thromb Vasc Biol. 17:1997;1157-1162.