Aspects of in vitro and in vivo research approaches directed toward identifying probiotics and prebiotics for human use

Journal of Nutrition

Volumn 130, Issue 2 SUPPL., 2000, Pages

  Gibson, Glenn R ^a   Fuller, Roy ^b  

^a UNIVERSITY OF READING   (United Kingdom)

^b Ryeish Green   (United Kingdom)

Author keywords

Gut microbiology; Prebiotic; Probiotic

Indexed keywords

CARBOHYDRATE; FRUCTOSE OLIGOSACCHARIDE; GALACTOSE OLIGOSACCHARIDE; GLUCOSE OLIGOSACCHARIDE; ISOMALTOSE OLIGOSACCHARIDE; LACTULOSE; PREBIOTIC AGENT; PROBIOTIC AGENT; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; XYLOSE OLIGOSACCHARIDE;

ANAEROBIC METABOLISM; BIFIDOBACTERIUM; CLINICAL RESEARCH; COLON FLORA; CONFERENCE PAPER; DIET SUPPLEMENTATION; FERMENTATION; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; MILK; NUTRITION;

BIFIDOBACTERIUM; MICROBIOTA;

EID: 0033985266     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.2.391s     Document Type: Conference Paper

References (49)

1. Andrieux, C. & Szylit, O. (1992) Effects of galacto-oligosaccharides (TOS) on bacterial enzyme activities and metabolite production in rats associated with a human faecal flora. Proc. Nutr. Soc. 51: 7A (abs.).
2. Benno, Y., Endo, K., Shiragami, N., Sayama, K. & Mitsuoka, T. (1987) Effects of raffinose intake on human fecal microflora. Bifid. Microflora 6: 59-63.
3. Bouhnik, Y., Flourie, B., D'Agay-Abensour, L., Pochart, P., Gramet, G., Durand, M. & Rambaud, J. C. (1997) Administration of transgalacto-oligosaccharides increases fecal bifidobacteria and modifies colonic fermentation metabolism in healthy humans. J. Nutr. 127: 444-448.
4. Bouhnik, Y., Flourie, B., Ouarne, F., Riottot, M., Bisetti, N., Bornet, F. & Rambaud, J. C. (1994) Effects of prolonged ingestion of fructo-oligosaccharides (FOS) on colonic bifidobacteria, fecal enzymes and bile acids in humans. Gastroenterology 106: A598 (abs.).
5. Buddington, R. K., Williams, C. H., Chen, S. & Witherly, S. A. (1996) Dietary supplement of neosugar alters the fecal flora and decreases activities of some reductive enzymes in human subjects. Am. J. Clin. Nutr. 63: 709-716.
6. Collins, F. M. & Carter, P. B. (1978) Growth of salmonellae in orally infected germfree mice. Infect. Immunol. 21: 41-47.
7. Collins, M. D. & Gibson, G. R. (1999) Probiotics, prebiotics and synbiotics: dietary approaches for the modulation of microbial ecology. Am. J. Clin. Nutr. 69: 1052-1057.
8. Crittenden, R. G. (1999) Prebiotics. In: Probiotics: A Critical Review (Tannock, G., ed.). Horizon Scientific Press, Wymondham, UK.
9. Desjardins, M. L., Roy, D. & Goulet, J. (1990) Growth of bifidobacteria and their enzyme profiles. J. Dairy Sci. 73: 299-307.
10. Djouzi, Z., Andrieux, C., Pelenc, V., Somarriba, S., Popot, F., Paul, F., Monsan, P. & Szylit, O. (1995) Degradation and fermentation of α-gluco-oligosaccharides by bacterial strains from human colon: in vitro and in vivo studies in gnotobiotic rats. J. Appl. Bacteriol. 79: 117-127.
11. Dumortier, V., Brassart, C. & Bouquelet, S. (1994) Purification and properties of a β-galactosidase from Bifidobacterium bifidum exhibiting a transgalactosylation reaction. Biotechnol. Appl. Biochem. 19: 341-354.
12. Durand, M., Cordelet, C., Hannequart, G. & Beaumatin, P. (1992) In vitro fermentation of a galacto-oligosaccharide by human bacteria in continuous culture. Proc. Nutr. Soc. 51: 6A (abs.).
13. Fadden, K. & Owen, R. W. (1992) Faecal steroids and colorectal cancer: the effect of lactulose on faecal bacterial metabolism in a continuous culture model of the large intestine. Eur. J. Cancer Prev. 1: 113-127.
14. Freter, R. (1955) The fatal enteric cholera infection in the guinea pig achieved by inhibition of normal enteric flora. J. Infect. Dis. 97: 57-65.
15. Fuller, R. (1989) Probiotics in man and animals. J. Appl. Bacteriol. 66: 365-378.
16. Gibson, G. R. & Wang, X. (1994a) Enrichment of bifidobacteria from human gut contents by oligofructose using continuous culture. FEMS Microbiol. Lett. 118: 121-128.
17. Gibson, G. R. & Wang, X. (1994b) Regulatory effects of bifidobacteria on the growth of other colonic bacteria. J. Appl. Bacteriol. 77: 412-420.
18. Gibson, G. R., Beatty, E. R., Wang, X. & Cummings, J. H. (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108: 975-982.
19. Gibson, G. R. & Roberfroid, M. B. (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J. Nutr. 125:1401-1412.
20. Gibson, G. R., Rastall R. A. & Roberfroid, M. B. (1999) Prebiotics. In: Colonic Microbiota, Nutrition and Health (Gibson, G. R. & Roberfroid., M. B., eds.) Kluwer Academic, Dordrecht, The Netherlands.
21. Hayakawa, K., Mizutani, J., Wada, K., Masai, T., Yoshihara, I. & Mitsuoka, T. (1990) Effects of soybean oligosaccharides on human faecal flora. Microb. Ecol. Health Dis. 3: 293-303.
22. Hidaka, H., Eida, T., Takizawa, T., Tokunaga, T. & Tashiro, Y. (1986) Effects of fructooligosaccharides on intestinal flora and human health. Bifid. Microflora 5: 37-50.
23. Hopkins, M. J., Cummings, J. H. & Macfarlane, G. T. (1998) Inter-species differences in maximum specific growth rates and cell yields of bifidobacteria cultured on oligosaccharides and other simple carbohydrate sources. J. Appl. Microbiol. 85: 381-386.
24. Ito, M., Deguchi, Y., Miyamori, A., Matsumoto, K., Kikuchi, H., Matsumoto, K., Kobayashi, Y., Yajima, T. & Kan, T. (1990) Effects of administration of galactooligosaccharides on the human fecal microflora, stool weight and abdominal sensation. Microb. Ecol. Health Dis. 3: 285-292.
25. Ito, M., Kimura, M., Deguchi, Y., Miyamori-Watabe, A., Yajima, T. & Kan, T. (1993) Effects of transgalactosylated disaccharides on the human intestinal microflora and their metabolism. J. Nutr. Sci. Vitaminol. 39: 279-288.
26. Kaneko, T., Kohmoto, T., Kikuchi, H., Shiota, M., Iino, H. & Mitsuoka, T. (1994) Effects of isomaltooligosaccharides with different degrees of polymerisation on human fecal bifidobacteria. Biosci. Biotechnol. Biochem. 58: 2288-2290.
27. Kleessen, B., Sykura, B., Zunft, H.-J. & Blaut, M. (1997) Effects of inulin and lactose on fecal microflora, microbial activity and bowel habit in elderly constipated persons. Am. J. Clin. Nutr. 65: 1397-1402.
28. Kohmoto, T., Fukui, F., Takaku, H., Machida, Y., Arai, M. & Mitsuoka, T. (1988) Effect of isomalto-oligosaccharides on human fecal flora. Bifid. Microflora 7: 61-69.
29. Kohmoto, T., Fukui, F., Takaku, H. & Mitsuoka, T. (1991) Dose-response test of isomaltooligosaccharides for increasing fecal bifidobacteria. Agric. Biol. Chem. 55: 2157-2159.
30. Macfarlane, G. T., Macfarlane, S. & Gibson, G. R. (1998) Validation of a three-stage compound continuous culture system for investigating the effect of retention time on the ecology and metabolism of bacteria in the human colonic microbiota. Microb. Ecol. 35: 180-187.
31. McBain, A. J. & Macfarlane, G. T. (1997) Investigations of bifidobacterial ecology and oligosaccharide metabolism in a three-stage compound continuous culture system. Scand. J. Gastoenterol. 32: 32-40.
32. McCartney, A. L., Wenzhi, W. & Tannock, G. W. (1996) Molecular analysis of the composition of the bifidobacterial and lactobacillus microflora of humans. Appl. Environ. Microbiol. 62: 4608-4613.
33. Metchnikoff, E. (1907) The Prolongation of Life. William Heinemann, London, UK.
34. Muramatsu, K., Onodera, S., Kikuchi, M. & Shiomi, N. (1994) Substrate specificity and subsite affinities of β-fructofuranosidase from Bifidobacterium adolescentis G1. Biosci. Biotechnol. Biochem. 58: 1642-1645.
35. Okazaki, M., Fujikawa, S. & Matsumoto, N. (1990) Effects of xylooligosaccharide on growth of bifidobacteria. J. Jpn. Soc. Nutr. Food Sci. 43: 395-401.
36. O'Sullivan, D. J. (1999) Methods for analysis of the intestinal microflora. In: Probiotics: A Critical Review (Tannock, G., ed.). Horizon Scientific Press, Wymondham, UK.
37. Parker, R. B. (1974) Probiotics, the other half of the antibiotic story. Anim. Nutr. Health 29: 4-8.
38. Rettger, F., Levy, M. N., Weinstein, K. & Weiss, J. E. (1935) Lactobacillus acidophilus and Its Therapeutic Application. Yale University Press, New Haven, CT.
39. Roberfroid, M. B. (1997) Health benefits of non-digestible oligosaccharides, In: Dietary Fiber in Health and Disease (Kritchevsky, D. & Bonfield, C., eds.), pp. 211-219. Plenum Press, New York, NY.
40. Rowland, I. R. & Tanaka, R. (1993) The effects of transgalactosylated oligosaccharides on gut flora metabolism in rats associated with a human faecal microflora, J. Appl. Bacteriol. 74: 667-674.
41. Saito, Y., Takano, T. & Rowland, I. (1992) Effects of soybean oligosaccharides on the human gut microflora in in vitro culture. Microb. Ecol. Health Dis. 5: 105-110.
42. Schwass, A., Sjolin, S. Trottestam, V. & Aransson, B. (1984) Relapsing Clostridium difficile enterocolitis cured by rectal infusion of normal faeces. Scand. J. Infect. Dis. 16: 211-215.
43. Suzuki, K., Endo, Y., Uehara, M., Yamada, H., Goto, S., Imamura, M. & Shioza, S. (1985) Effect of lactose, lactulose and sorbital on mineral utilisation and intestinal flora. J. Jpn. Soc. Nutr. Food Sci. 38: 39-42.
44. Tamura, Z. (1983) Nutriology of bifidobacteria. Bifid. Microflora 2: 3-16.
45. Tariaka, R., Takayama, H., Morotomi, M., Kuroshima, T., Ueyama, S., Matsumoto, K., Kuroda, A. & Mutai, M. (1983) Effects of administration of TOS and Bifidobacterium breve 4006 on the human fecal flora. Bifid. Microflora 2: 17-24.
46. Van Loo, J.A.E., Coussement, P., De Leenheer, L., Hoebregs, H. & Smits, G. (1995) On the presence of inulin and oligofructose as natural ingredients in the western diet. CRC Crit. Rev. Food Sci. Nutr. 35: 525-552.
47. Wang, X. & Gibson, G. R. (1993) Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine. J. Appl. Bacteriol. 75: 373-380.
48. Williams, C. H., Witherly, S. A. & Buddington, R. K. (1994) Influence of dietary neosugar on selected bacterial groups of the human faecal microbiota. Microb. Ecol. Health Dis. 7: 91-97.
49. Yazawa, K., Imai, K. & Tamura, Z. (1978) Oligosaccharides and polysaccharides specifically utilisable by bifidobacteria, Chem. Pharm. Bull. 26: 3306-3311.