Target pharmacology of topiramate, a new antiepileptic drug

Folia Pharmacologica Japonica

Volumn 115, Issue 1, 2000, Pages 53-57

  Nakamura, Joji ^a   Kuwana, Yoshihisa ^a   Yukitoshi, Nobuyuki ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Anticonvulsant; Antiepileptic drug; Topiramate

Indexed keywords

4 AMINOBUTYRIC ACID; AMPA RECEPTOR; SODIUM CHANNEL; TOPIRAMATE;

ARTICLE; CHLORIDE TRANSPORT; ELECTRIC SHOCK; EPILEPSY; FOCAL EPILEPSY; SEIZURE;

EID: 0033983425     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.115.53     Document Type: Article

References (20)

1. Maryanoff BE, Nortey SO, Gardocki JF, Shank RP and Dodgson SP: Anticonvulsant O-alkyl sulfamates. 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate and related compounds. J Med Chem 30, 880-887 (1987)
2. Shank RP, Gardocki JF, Vaught JL, Davis CB, Schupsky JJ, Raffa RB, Dodgson SJ, Nortey SO and Maryanoff BE: Topiramate: preclinical evaluation of a structurally novel anticonvulsant. Epilepsia 35, 450-460 (1994)
3. Swinyard EA, Woodhead JH, White HS and Franklin MR: General principles: experimental selection, quantification and evaluation of anticonvulsants. In Antiepileptic Drugs, third edition, Edited by Levy R, Mattson R, Meldrum B, Penry JK and Dreifuss FE, pp 85-102, Raven Press, New York (1989)
4. Wauquier A and Zhou S: Topiramate: a potent anticonvulsant in the amygdala-kindled rat. Epilepsy Res 24, 73-77 (1996)
5. Amano K, Hamada K, Yagi K and Seino M: Antiepileptic effects of topiramate on amygdaloid kindling in rats. Epilepsy Res 31, 123-128 (1998)
6. Nakamura J, Tamura S, Kanda T, Ishii A, Ishihara K, Serikawa T, Yamada J and Sasa M: Inhibition by topiramate of seizures in spontaneously epileptic rats and DBA 2 mice. Eur J Pharmacol 254, 83-89 (1994)
7. Sasa M, Ohno Y, Ujihara H, Fujita Y, Yoshimura M, Takaori S, Serikawa T and Yamada J: Effects of antiepileptic drugs on absence-like and tonic seizures in the spontaneously epileptic rat, a double mutant rat. Epilepsia 29, 505-513 (1988)
8. Kanda T, Kurokawa M, Tamura S, Nakamura J, Ishii A, Kuwana Y, Serikawa T, Yamada J, Ishihara K and Sasa M: Topiramate reduces abnormally high extracellular levels of glutamate and aspartate in the hippocampus of spontaneously epileptic rats (SER). Life Sci 59, 1607-1616 (1996)
9. Coulter DA, Sombati S and DeLorenzo RJ: Selective effects of topiramate on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons. Epilepsia 34 (Suppl 2), 123 (1993)
10. Zona C, Ciotti MT and Avoli M: Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells. Neurosci Lett 231, 123-126 (1997)
11. White HS, Brown SD, Woodhead JH, Skeen GA and Wolf HH: Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. Epilepsy Res 28, 167-179 (1997)
12. White HS, Brown D, Skeen GA, Wolf HH and Twyman RE: The anticonvulsant topiramate displays a unique ability to potentiate GABA-evoked chloride currents. Epilepsia 36 (Suppl 3), S39 (1995)
13. Severt L, Coulter DA, Sombati S and DeLorenzo RJ: Topiramate selectively blocks kainate currents in cultured hippocampal neurons. Epilepsia 36 (Suppl 4), 38 (1995)
14. Yang Y, Shuaib A, Li Q and Siddiqui MM: Neuroprotection by delayed administration of topiramate in a rat model of middle cerebral artery embolization. Brain Res 804, 169-176 (1998)
15. Sharief M, Viteri C, Ben-Menachem E, Weber M, Reife R, Pledger G and Karim R: Double-blind, placebo-controlled study of tcpiramate in patients with refractory epilepsy. Epilepsy Res 25, 217-224 (1996)
16. Tassinari CA, Michelucci R, Chodkiewicz J, Shorvon S, Henriksen O, Dam M, Reife R, Pledger G and Karim R: Double-blind, placebo-controlled trial of topiramate (600 mg daily) for the treatment of refractory partial epilepsy. Epilepsia 37, 763-768 (1996)
17. Ben-Menachem E, Henriksen O, Dam M, Mikkelsen M, Schmidt D, Reid S, Reife R, Kramer L, Pledger G and Karim R: Double-blind placebo-controlled trial of topiramate as add-on therapy in patients with refractory partial seizures. Epilepsia 37, 539-543 (1996)
18. Faught E, Wilder BJ, Ramsay RE, Reife RA, Kramer LD, Pledger GW, Karim RM and the Topiramate YD Study Group: Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages. Neurology 46, 1684-1690 (1996)
19. Privitera M, Fincham R, Penry J, Reife R, Kramer L, Pledger G, Karim R and the Topiramate YE Study Group: Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1,000-mg daily dosages. Neurology 46, 1678-1683 (1996)