Skeletal changes in rats bearing mammosomatotrophic pituitary tumors: A model of acromegaly with gonadal dysfunction

Bone

Volumn 26, Issue 3, 2000, Pages 255-261

  Morimoto, I ^a   Kai, K ^a   Okada, Y ^a   Okimoto, N ^a   Uriu, K ^a   Akino, K ^b   Yamashita, S ^b   Nakamura, T ^a   Eto, S ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acromegaly; Bone formation; Bone resorption; Growth hormone; Hypogonadism; Prolactin

Indexed keywords

ESTRADIOL; GROWTH HORMONE; PROLACTIN;

ACROMEGALY; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BONE MASS; BONE MINERAL; BONE STRENGTH; BONE TURNOVER; CELL STRAIN GH3; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; FEMUR; GROWTH HORMONE BLOOD LEVEL; HYPOPHYSIS TUMOR; NONHUMAN; PROLACTIN BLOOD LEVEL; RAT; TRABECULAR BONE; VERTEBRA BODY;

ACROMEGALY; ANIMALS; BODY WEIGHT; BONE AND BONES; FEMALE; HYPERPROLACTINEMIA; HYPOGONADISM; PITUITARY NEOPLASMS; RATS; RATS, WISTAR;

EID: 0033982638     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(99)00274-4     Document Type: Article

References (49)

1. Adler R.A., Evani R., Mansouri A., Krieg R.J. Relative effect of prolactin excess and estrogen deficiency on bone in rats. Metabolism. 47:1998;425-428.
2. Andreassen T.T., Jørgensen P.H., Flyvbjerg A., Ørskov H., Oxlund H. Growth hormone stimulates bone formation and strength of cortical bone in aged rats. J Bone Miner Res. 10:1995;1057-1067.
3. Andreassen T.T., Melsen F., Oxlund H. The influence of growth hormone on cancellous and cortical bone of the vertebral body in aged rats. J Bone Miner Res. 11:1996;1094-1102.
4. Andreassen T.T., Oxlund H. Additive anabolic effects of growth hormone and parathyroid hormone on vertebral body cortical and cancellous bone in old ovariectomized rats. J Bone Miner Res. 11:(Suppl. 1):1996;457.
5. Avioli L., Raisz L.G. Bone metabolism and disease. Bondy P., Rosenberg L. Metabolic Control and Disease. 1980;1709-1814 WB Saunders, Philadelphia.
6. Bagi C.M., Brommage R., Deleon L., Adams S., Rosen D., Sommer A. Benefit of systemically administered rhIGF-1 and rhIFG-1/IGFBP-3 on cancellous bone in ovariectomized rats. J Bone Miner Res. 9:1994;1301-1312.
7. Bataille S.N., Gerland K., Chappard D., Basle M.F., Mercier L. Expression of prolactin receptors in human osteosarcoma cells. Biochem Biophys Res Commun. 229:1996;323-328.
8. Baum H.B.A., Biller B.M.K., Finkelstein J.S., Cannistraro K.B., Oppenheim D.S., Schoenfeld D.A., Michel T.H., Wittink H., Klibanski A. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial. Ann Intern Med. 125:1996;883-890.
9. 47Ca metabolism in acromegaly. J Clin Endocrinol Metab. 27:1967;178-184.
10. Bravenboer N., Holzmann P., Boer H.D., Roos J.C., van der Veen E.A., Lips P. The effects of growth hormone (GH) on histomorphometric indices of bone structure and bone turnover in GH-deficient men. J Clin Endocrinol Metab. 82:1997;1818-1822.
11. Chen M-M, Yeh J.K., Aloia J.F. Effect of ovarietomy on cancellous bone in the hypophysectomized rat. J Bone Miner Res. 10:1993;1334-1342.
12. Clément-Lacroix P., Ormandy C., Lepescheux L., Ammann P., Damotte D., Goffin V., Bouchard B., Amling M., Gaillard-Kelly M., Binart N., Baron R., Kelly P.A. Osteoblasts are a new target for prolactin analysis of bone formation in prolactin receptor knockout mice . Endocrinology. 140:1999;96-105.
13. Danielsen C.C., Flyvbjerg A. Insulin-like growth factor I as a predictor of cortical bone mass in a long-term study of ovariectomized and estrogen-treated rats. Bone. 19:1996;493-498.
14. Danielsen C.C., Mosekilde L., Svenstrup B. Cortical bone mass, composition, and mechanical properties in female rats in relation to age, long-term ovariectomy, and estrogen substitution. Calcif Tissue Int. 52:1993;26-33.
15. Diamond T., Nery L., Posen S. Spinal and peripheral bone mineral densities in acromegaly the effects of excess growth hormone and hypogonadism . Ann Int Med. 111:1989;567-573.
16. Ezzat S., Melmed S., Endres D., Eyre D.R., Singer F.R. Biochemical assessment of bone formation and resorption in acromegaly. J Clin Endocrinol Metab. 76:1993;1452-1457.
17. Felson D.T., Zhang Y., Hannan M.T., Anderson J.J. Effects and body mass index on bone mineral density in men and women the Framingham study . J Bone Miner Res. 8:1993;567-572.
18. Halse J., Melsen F., Mosekilde L. Iliac crest bone mass and remodelling in acromegaly. Acta Endocrinol (Copenh). 97:1981;18-22.
19. Ho P.J., Fig L.M., Barkan A.L., Shapiro B. Bone mineral density of the axial skeleton in acromegaly. J Nuclear Med. 33:1992;1608-1612.
20. Johannsson G., Rosén T., Bosaeus I., Sjöström L., Bengtsson B-Å. Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency. J Clin Endocrinol Metab. 81:1996;2865-2873.
21. Johansen J.S., Pedersen S.A., Jørgensen J.O., Riis B.J., Christiansen C., Christiansen J.S., Skakkebaek N.E. Effects of growth hormone (GH) on plasma bone Gla protein in GH-deficient adults. J Clin Endocrinol Metab. 70:1990;916-919.
22. Jorgenssen P.H., Bak B., Andreassen T.T. Mechanical properties and biochemical composition of rat cortical femur and tibia after long-term treatment with biosynthetic human growth hormone. Bone. 12:1991;353-359.
23. Kalu D.N. Evaluation of the pathogenesis of skeletal changes in ovariectomized rats. Endocrinology. 115:1984;507-512.
24. Kidder L.S., Schmidt I.U., Evans G.L., Turner R.T. Effects of growth hormone and low dose estrogen on bone growth and turnover in long bones of hypophysectomized rats. Calcif Tissue Int. 61:1997;327-335.
25. Klibanski A., Neer R.M., Beitins I.Z., Ridgway E.C., Zervas N.T., McArthur J.W. Decreased bone density in hyperprolactinemic women. N Engl J Med. 303:1980;1511-1514.
26. Kotzmann H., Bernecker P., Hübsch P., Pietschmann P., Woloszczuk W., Svoboda T., Geyer G., Luger A. Bone mineral density and parameters of bone metabolism in patients with acromegaly. J Bone Miner Res. 8:1993;459-465.
27. 45Ca uptake, calcium deposit, and calcium resorption in weaned, young, and mature rats. Can J Physiol Pharmacol. 74:1996;1157-1165.
28. Lachelin G.C.L., Abu-Fadil S., Yen S.C.C. Functional delineation of hyperprolactinemic-amenorrhea. J Clin Endocrinol Metab. 44:1977;1163-1174.
29. Marcus R., Butterfield G., Holloway L., Gilliland L., Baylink D.J., Hintz R.L., Sherman B.M. Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab. 70:1990;519-527.
30. Motoie H., Nakamura T., O'uchi N., Nishikawa H., Kanoh H., Abe T., Kawashima H. Effects of the bisphosphonate YM175 on bone mineral density, strength, structure, and turnover in ovariectomized beagles on concomitant dietary calcium restriction. J Bone Miner Res. 10:1995;910-920.
31. Nadarajah A., Hartog M., Redfern B., Thalassinos N., Wright A.D., Joplin G.F., Fraser T.R. Calcium metabolism in acromegaly. Brit Med J. 4:1968;797-801.
32. Nakano Y., Watanabe K., Morimoto I., Okada Y., Ura K., Sato K., Kasano K., Nakamura T., Eto S. 1994 Interleukin-4 inhibits spontaneous and parathyroid-related protein-stimulated osteoclast formation in mice. J Bone Miner Re. 9:1994;1533-1539.
33. Noland K., Orhii P., Rutstein J., Kalu D. Effect of growth hormone therapy on cortical bone in aged ovariectomized rats. J Bone Miner Res. 11:(Suppl):1995;458.
34. Ohlsson C., Bengtsson B-Å., Isaksson O.G.P., Andreassen T.T., Slootweg M.C. Growth hormone and bone. Endocr Rev. 19:1998;55-80.
35. Okimoto K., Tsurukami H., Okazaki Y., Nishida S., Sakai A., Ohnishi H., Hori M., Yasukawa K., Nakamura T. Effects of a weekly injection of human parathyroid hormone (1-34) and withdrawal on bone mass, strength, and turnover in mature ovariectomized rats. Bone. 22:1998;523-531.
36. Orhii P., Noland K., Rutstein J., Kalu D. Effect of growth hormone therapy on cancellous bone in aged ovariectomized rats. J Bone Miner Res. 11:(Suppl. 1):1996;458.
37. Ohta T., Azuma Y., Kiyoki M., Eguchi H., Arita M., Hosoda K., Tsukamoto Y., Nakamura T. 01996 Measurement of intact rat osteocalcin in osteoblast (ROS17/2.8) cells and in ovariectomized rats with a sandwich enzyme immunoassay. Calcif Tissue Int. 50:1996;283-290.
38. Oxlund H., Ortof G., Andreassen T.T. Effects of growth hormone on vertebral cancellous bone compressive strength in old rats. J Bone Miner Res. 23:(Suppl.):1998;A583.
39. Peake G.T., Marz I.K., Daughaday W.H. Radioimmunoassay of growth hormone in rats bearing somatotropin producing tumors. Endocrinology. 83:1968;714-720.
40. Riggs B.L., Randall R.V., Wahner H.W., Jowsey J., Kelly P.J., Singh M. The nature of the metabolic bone disorder in acromegaly. J Clin Endocrinol Metab. 34:1972;911-918.
41. Sandstedt J., Törnell J., Norjavaara E., Isaksson O.G.P., Ohlsson C. Elevated levels of growth hormone increase bone mineral content in normal young mice, but not in ovariectomized mice. Endocrinology. 137:1996;3368-3374.
42. Schlemmer A., Johansen J.S., Pederson S.A., Jørgensen J.O., Hassager C., Christiansen C. The effect of growth hormone (GH) therapy on urinary pyridinoline cross-linked in GH-deficient adults. Clin Endocrinol. 36:1991;471-478.
43. Seeman E., Wahner H.W., Offord K.P., Kumar R., Johnson W.J., Riggs B.L. Differential effects of endocrine dysfunction on the axial and the appendicular skeleton. J Clin Invest. 69:1982;1302-1309.
44. Thorner M.O., Vance M.L., Laws E.R., Horvath E., Kovacs K. The anterior pituitary. Wilson J.D., Foster D.W., Kronenberg H.M., Larsen P.R. Williams Textbook of Endocrinology (9th ed). 1998;249-340 WB Saunders, Philadelphia.
45. Turner R.T. Effects of short-term spaceflight and recombinant human growth hormone (rhGH) on bone growth in young rats. Aviat Space Environ Med. 66:1995;763-769.
46. Turner R.T., Vandersteehoven J.J., Bell N.H. The effects of ovariectomy and 17-β estradiol on cortical bone histomorphometry in growing rats. J Bone Miner Res. 2:1987;115-122.
47. Wright N.M., Renault J., Hollis B., Bell N.H., Key L.I. Effect of growth hormone on bone bone mineral density, trabecular bone volume, and alkaline phosphatase improve or are restored in the dwarf rat treated with growth hormone . J Bone Miner Res. 10:1995;127-131.
48. Yamashita S., Slanina S., Kado H., Melmed S. Autoregulation of pituitary growth hormone messenger ribonucleic acid levels in rats bearing transplantable mammosomatotrophic pituitary tumors. Endocrinology. 118:1986;915-918.
49. Yeh J.K., Chen M-M, Aloia J.F. Effects of estrogen and growth hormone on skeletal in the ovariectomized rat with hypophysectomy. Am J Physiol. 273:1997;E734-E742.