Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjogren's syndrome (SS) through up-regulated Th2 response

Clinical and Experimental Immunology

Volumn 119, Issue 2, 2000, Pages 354-360

  Saegusa, K ^a   Ishimaru, N ^a   Yanagi, K ^a   Haneji, N ^a   Nishino, M ^a   Azuma, M ^b   Saito, I ^a   Hayashi, Y ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b Division of Immunlogy   (Japan)

Author keywords

fodrin; Autoantigen; CD86 costimulation; Preventive effect; Sjogren's syndrome; Th2 cytokine

Indexed keywords

AUTOANTIGEN; FODRIN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD86; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; FEMALE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; LACRIMAL GLAND; LYMPHOCYTE PROLIFERATION; MUTANT; NONHUMAN; PRIORITY JOURNAL; SALIVARY GLAND; SJOEGREN SYNDROME; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD86; AUTOANTIBODIES; AUTOANTIGENS; CARRIER PROTEINS; CYTOKINES; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, MUTANT STRAINS; MICROFILAMENT PROTEINS; SJOGREN'S SYNDROME; TH1 CELLS; TH2 CELLS; UP-REGULATION;

EID: 0033981280     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01121.x     Document Type: Article

References (44)

1. Bretcher P. The two-signal model of lymphocyte activation twenty-one years later. Immunol Today 1992; 13:74-6.
2. Schwartz RH. Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992; 71:1065-8.
3. Azuma M, Yssel H, Phillips JH, Spits H, Lanier LL. Functional expression of B7/BB1 on activated T lymphocytes. J Exp Med 1993; 177:845-50.
4. Azuma M, Ito D, Yagita H, Okumura K, Phillip JH, Lanier LL, Somoza C. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 1993; 366:76-9.
5. Linsley PS, Clark EA, Ledbetter JA. The T cell antigen, CD28, mediates adhesion with B cells by interacting with the activation antigen B7. Proc Natl Acad Sci USA 1990; 87:5031-5.
6. Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Ann Rev Immunol 1993; 11:191-212.
7. Linsley PS, Grreen JL, Brady W, Bajorath J, Ledbetter JA, Peach R. Human B7-1 (CD80) and B7-2 (CD86) binds with similar avidity but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994; 1:793-801.
8. Sansom DM, Hall ND. B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vivo. Eur J Immunol 1993; 23:295-8.
9. Linsley PS, Green JA, Tan P, Gradshaw J. Co-expression and functional co-operation of CTLA-4 and CD28 on activated T lymphocyte. J Exp Med 1992; 176:1595-604.
10. Linsley PS, Greene JL, Tan P, Gradshaw J, Ledbetter JA. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med 1992; 176:1595-604.
11. Kuchroo VK, Das MP, Brown JA et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathways: Application to autoimmune disease therapy. Cell 1995; 80:707-18.
12. Lenschow DJ, Herold KC, Rhee L et al. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity 1996; 5:285-93.
13. Tsuyuki S, Tsuyuki J, Einsle K, Kopf M, Coyle AJ. Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. J Exp Med 1997; 185:1671-9.
14. + Th2 cells for contact hypersensitivity. J Immunol 1997; 159:4217-26.
15. Bloch K, Buchanan W, Wohl M, Bunim J. Sjögren's syndrome. A clinical, pathological and serological study of sixty-two cases. Medicine 1965; 44:187-231.
16. Moutsopoulos HM, Chused TM, Mann DL, Klippel JH, Fauci AS, Frank MM, Lawley TJ, Hamburger MI. Sjögren's syndrome (sicca syndrome): Current issues. Ann Intern Med 1980; 92:212-6.
17. Fox RI, Robinson CA, Curd JG, Kozin F, Howell FV. Sjögren's syndrome. Proposed criteria for classification. Arthritis Rheum 1986; 29:577-85.
18. Hayashi Y, Kojima A, Hata M, Hirokawa K. A new mutation involving the sublingual gland in NFS/N mice. Partially arrested mucous cell differentiation. Am J Pathol 1988; 132:187-91.
19. Haneji N, Hamano H, Yanagi K, Hayashi Y. A new animal model for primary Sjögren's syndrome in NFS/sld mutant mice. J Immunol 1994; 153:2769-77.
20. Hayashi Y, Haneji N, Hamano H, Yanagi K, Takahashi M, Ishimaru N. Effector mechanism of experimental autoimmune sialadenitis in the mouse model for primary Sjögren's syndrome. Cell Immunol 1996; 171:217-25.
21. Takahashi M, Mimura Y, Hamano H, Haneji N, Yanagi K, Hayashi Y. Mechanism of the development of autoimmune dacryoadenitis in the mouse model for primary Sjögren's syndrome. Cell Immunol 1996; 170:54-62.
22. Haneji N, Nakamura T, Takio K et al. Identification of α-fodrin as a candidate autoantigen in primary Sjögren's syndrome. Science 1997; 276:604-7.
23. White SC, Casarett GW. Induction of experimental autoallergic sialadenitis. J Immunol 1974; 112:178-85.
24. Ishimaru N, Saegusa K, Yanagi K, Haneji N, Saito I, Hayashi Y. Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjögren's syndrome through Fas-mediated apoptosis. Am J Pathol 1999; 155:173-81.
25. Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ. Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function. J Exp Med 1994; 180:631-40.
26. Lenschow DJ, Su GHT, Zuckerman LA, Nabavi N, Jellis CL, Gray GS, Miler J, Bluestone JA. Expression and functional significance of an additional ligand for CTLA4. Proc Natl Acad Sci USA 1993; 90:11054-8.
27. Lenschow DJ, Sperling AI, Cooke MP et al. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J Immunol 1994; 153:1990-7.
28. Chen C, Faherty DA, Gault A, Connaughton SE, Power GD, Godfrey DI, Nabavi N. Monoclonal antibody 2D10 recognizes a novel T cell costimulatory molecule on activated murine B lymphocytes. J Immunol 1994; 152:2105-14.
29. Chen C, Gault A, Shen L, Nabavi N. Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule. J Immunol 1994; 152:4929-36.
30. + T lymphocytes. J Immunol 1993; 151:2368-79.
31. Freeman GJ, Boussiotis VA, Anumanthan A et al. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 1995; 2:523-32.
32. Gallon L, Chandraker A, Issazadeh S, Peach R, Linsley PS, Turka LA, Sayegh MH, Khoury SJ. Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model. J Immunol 1997; 159:4212-6.
33. Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, Herold KC, Bluestone JA. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med 1995; 181:1145-55.
34. Rache MK, Scott DE, Quigley L, Gray GS, Abe R, June CH, Perrin PJ. Distinct roles for B7-1 (CD80) and B7-2 (CD86) in the initiation of experimental allergic encephalomyelitis. J Clin Invest 1995; 96:2195-203.
35. Thompson CB. Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell 1995; 81:979-82.
36. Gause WC, Mitro V, Via C, Linsley P, Urban JF Jr, Greenwald RJ. Do effector and memory T helper cells also need B7 ligand costimulatory signals? J Immunol 1997; 159:1055-8.
37. Keane-Myers A, Gause WC, Linsley PS, Chen S-J, Wills-Karp M. B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens. J Immunol 1997; 158:2042-9.
38. Larsen CP, Ritchie SC, Hendrix R, Linsley PS, Hathcock KS. Hodes RJ, Lowley RP, Pearson TC. Regulation of immunostimulatory function and costimulatory molecules (B7-1 and B7-2) expression on murine dendric cells. J Immunol 1994; 152:5208-19.
39. Baron JL, Madri JA, Ruddle NH, Hashim G, Janeway JCA. Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyme. J Exp Med 1993; 177:57-68.
40. Kuchroo VK, Martin CA, Greer JM, Ju S-T, Sobel RA, Dorf ME. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J Immunol 1993; 151:4371-82.
41. Khoury SJ, Hancock WW, Weiner HL. Oral tolerance to myelin basic protein and natural recovery from experimental allergic encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor-β, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 1992; 176:1355-64.
42. Nakajima A, Azuma M, Kodera S et al. Preferential dependence of autoantibody production in murine lupus on CD86 co-stimulatory molecule. Eur J Immunol 1995; 25:3060-9.
43. Mosmann TM, Sad S. The expanding universe of T-cell sunsets: Th1, Th2 and more. Immunol Today 1996; 17:138-46.
44. Lakkis FG, Konieczny BT, Saleem S et al. Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4. J Immunol 1997; 158:2443-8.