Antigen-presenting cells and keratinocytes express interleukin-12 in allergic contact dermatitis

Contact Dermatitis

Volumn 42, Issue 1, 2000, Pages 18-22

  Yawalkar, N ^a,b   Egli, F ^a   Brand, C U ^a   Pichler, W J ^a   Braathen, L R ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Allergic contact dermatitis; Dendritic cells; Immunohistochemistry.; Interleukin 12

Indexed keywords

INTERLEUKIN 12;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; EPIDERMIS; EXOCYTOSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KERATINOCYTE; LANGERHANS CELL; MACROPHAGE; MALE; PATCH TEST; PATHOGENESIS; SKIN ALLERGY; SKIN BIOPSY; T LYMPHOCYTE ACTIVATION;

ADULT; ANTIGEN-PRESENTING CELLS; DERMATITIS, ALLERGIC CONTACT; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-12; KERATINOCYTES; MALE; MIDDLE AGED;

EID: 0033978529     PISSN: 01051873     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0536.2000.042001018.x     Document Type: Article

References (26)

1. 1. Krasteva M et al. Contact dermatitis I. Pathophysiology of contact sensitivity. Eur J Dermatol 1999: 9: 65-77.
2. 2. Grabbe S, Schwarz T. Immunoregulatory mechanisms involved in elicitation of allergie contact hypersensitivity. Immunol Today 1998:19: 37-44.
3. 3. Cavani A et al. Patients with allergie contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells. J Invest Dermatol 1998: 111: 621-628.
4. 4. Moulon C, Wild D, Dormoy A, Weltzien H U. MHC-dependent and -independent activation of human nickel-specific CD8+ cytotoxic T cells from allergic donors. J Invest Dermatol 1998:111: 360-366.
5. 5. Bouloc A, Cavani A, Katz S I. Contact hypersensitivity in MHC class II-deficient mice depends on CD8 T lymphocytes primed by immunostimulating Langerhans cells. J Invest Dermatol 1998:111: 44-49.
6. 6. Kehren J et al. Cytotoxicity is mandatory for CD8(+) T Cell-mediated contact hypersensitivity. J Exp Med 1999: 189: 779-786.
7. 7. Ma X, Aste-Amezaga M, Gri G, Gerosa F, Trinchieri G. Immunomodulatory functions and molecular regulation of IL-12. In: Adorini L (eds). IL-12. Chem Immunol 1997: 68: 1-22.
8. 8. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995: 13: 251-276.
9. 9. Riemann H et al. Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten-specific tolerance. J Immunol 1996: 156: 1799-1803.
10. 10. Müller G et al. Identification and induction of human keratinocyte-derived IL-12. J Clin Invest 1994: 94: 1799-1805.
11. 11. Xu B, Aoyama K, Kitani A, Yu S, Matsuyama T, Matsushita T. Interleukin-12 enhances contact hypersensitivity by modulating the in vivo cytokine pattern in mice. J Interferon Cytokine Res 1998: 18: 23-31.
12. 12. Di Iulio N A, Xu H, Fairchild R L. Diversion of CD4+ T cell development from regulatory T helper to effector T helper cells alters the contact hypersensitivity response. Eur J Immunol 1996: 26: 2606-2612.
13. 13. Saulnier M, Huang S, Aguet M, Ryffel B. Rôle of interferon-gamma in contact hypersensitivity assessed in interferon-gamma receptor-deficient mice. Toxicology 1995: 102: 301-312.
14. 14. Ulfgren A K, Lindblad S, Klareskog L, Andresson J, Andresson U. Detection of cytokine producing cells in the synovial membrane from patients with rheumatoid arthritis. Annals Rheumatic Diseases 1995: 54: 654-661.
15. 15. D'Andrea A et al. Production of natural killer cell stimulatory factor (interleukin-12) by peripheral blood mono-nuclear cells. J Exp Med 1992: 176: 1387-1398.
16. 16. Yawalkar N, Brand C U, Braathen L R. IL-12 gene expression in human skin derived CD1a+ dendritic lymph cells. Arch Derm Res 1996: 288: 79-84.
17. 17. Kang K, Kubin M, Cooper K D, Lessin S R, Trinchieri G, Rook A H. IL-12 synthesis by human Langerhans cells. J Immunol 1996: 156: 1402-1407.
18. 18. Scheicher C et al. Uptake of microparticle-adsorbed protein antigen by marrow-derived dendritic cells results in upregulation of interleukin-1 and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation. Eur J Immunol 1995: 25: 1566-1572.
19. 19. Shu U et al. Activated T cells induce interleukin-12 production by monocytes via CD4O-CD40 ligand interaction. Eur J Immunol 1995: 25: 1125-1128.
20. 20. Cella M et al. Ligation of CD 40 on dendritic cells triggers production of high levels of Interleukin 12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996: 184: 747-752.
21. 21. Kato T, Hakamada R, Yamane H, Nariuchi H. Induction of IL-12 p-40 messenger RNA expression and IL-12 macrophages via CD4O-CD40 ligand interaction. J Immunol 1996: 156: 3932-3938.
22. 22. Koch F et al. High level II-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J Exp Med 1996: 184: 741-746.
23. 23. Xu H, Banerjee A, Dilulio N A, Fairchild R L. T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tcl) effector CD8+ T cells and interleukin (II) 4/II-10-producing (Th2) negative regulatory CD4+ T cells. J Exp Med 1996: 183: 1001-1012.
24. 24. Bour H et al. Major histocompatibility complex class I-restricted CD8 + T cells and class II-restricted CD4+ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene. Eur J Immunol 1995: 25: 3006-3010.
25. 25. Aragane Y et al. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol 1994: 153: 5366-5372.
26. 26. Yawalkar N, Limat A, Brand C U, Braathen L R. Constitutive expression of both subunits of interleukin-12 in human keratinocytes. J Invest Dermatol 1996: 106: 80-83.