Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten-specific tolerance

Journal of Immunology

Volumn 156, Issue 5, 1996, Pages 1799-1803

  Riemann, Helge ^a   Schwarz, Agatha ^a   Grabbe, Stephan ^a   Aragane, Yoshinori ^a   Luger, Thomas A ^a   Wysocka, Maria ^b   Kubin, Marek ^b   Trinchieri, Giorgio ^b   Schwarz, Thomas ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTACT ALLERGY; CONTACT SENSITIZATION; HELPER CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST;

ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; BINDING, COMPETITIVE; DERMATITIS, ALLERGIC CONTACT; DERMATITIS, IRRITANT; DINITROFLUOROBENZENE; HAPTENS; IMMUNE TOLERANCE; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MOLECULAR SEQUENCE DATA;

EID: 0030027749     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Kobayashi, M., L Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R Loundon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J. Exp Med. 170:827.
2. Stern, A S , F J. Podlaski, J. D. Hulmes, Y. C. Pan, P. M. Quinn, A. G Wolitzky, P. C. Familetti, D. L. Stremlo, T Truitt, R. Chizzonte, and M. K. Gately 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87:6808.
3. Muller, G., J. Saloga, T. Germann, I Bellinghausen, M Mohamadzadeh, J. Knop, and A. H Enk. 1994. Identification and induction of human keratinocyte-derived IL-12. J. Clin Invest. 94:1799.
4. Aragane, Y., H. Riemann, R. S. Bhardwaj, A Schwarz, Y. Sawada, H Yamada, T. A. Luger, M. Kubin, G. Trinchieri, and T. Schwarz. 1994. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J. Immunol. 153: 5366.
5. Gubler U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, P. C Familletti, and M. K. Gately. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88:4143.
6. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
7. Manetti, R., P. Parronchi, M. G. Giudizi, M.-P. Piccinni, E Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp. Med 177:1199.
8. Manetti, R., F. Gerosa, M. G Giudizi, R. Biagiotti, P. Parronchi, M.-P. Piccinni, S. Sampognaro, E Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for interferon-γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones J Exp. Med. 179.1273.
9. + cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
10. Wu, C.-Y , C Demeure, M. Kiniwa, M. Gately, and G. Delespesse. 1993. IL-12 induces the production of IFN-γ by neonatal human CD4 T cells. J. Immunol 151:1938.
11. Sypeck, J. P., C. L. Chung, S. E. H. Mayor, J. M. Subramanyam, S. J. Goldman, D S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797.
12. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp Med. 177:1505.
13. Reiner, S L., S. Zheng, Z.-E. Wang, L. Stowring, and R. M. Locksley. 1994. Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. J. Exp Med. 179:447.
14. Hauser, C. 1990. Cultured epidermal Langerhans cells activate effector T cells for contact sensitivity. J. Invest. Dermatol. 95:436
15. Becker, D., and J. Knop. 1994. Epidermal cell-derived cytokines and delayed-type hypersensitivity. In: Epidermal Growth Factors and Cytokines. T. A. Luger, T. Schwarz, eds. Marcel Dekker, New York, p. 365.
16. Schwarz, T., and T. A. Luger. 1992. Pharmacology of cytokines. In: Pharmacology of the Skin. Mukhtar H, ed. CRC Press, Boca Raton, FL, p. 283.
17. Toews, G. B., P. R. Bergstresser, and J. W. Streilein. 1980. Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J. Immunol. 124:445
18. Rook, A. H , K. Kang, M. Kubin, M. Cassin, G. Trinchieri, S. R. Lessin, and K D. Cooper 1994. Interleukin 12 mRNA and protein production by epidermal Langerhans cells. Clin. Res. 42:231a (Abstr.).
19. Schwarz, A., St Grabbe, H Riemann, Y. Aragane, M. Simon, S. Manon, S. Andrade, T. A Luger, and T Schwarz. 1994. In vivo effects of interleukin-10 on contact and delayed-type hypersensitivity reactions J. Invest. Dermatol. 103: 211.
20. Schwarz, A., C. Krone, F. Trautinger, Y Aragane, P. Neuner, T. A. Luger, and T Schwarz 1993. Pentoxifylline suppresses irritant and contact hypersensitivity reactions. J. Invest. Dermatol. 101:549.
21. Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc Natl. Acad. Sci. USA 81:1991
22. Schuler, G., and R. M. Steinman. 1985. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161:526.
23. Bette, M., S. C. Jin, T. Germann, M. K. H. Schafer, E Weihe, E. Rüde, and B. Fleischer. 1994 Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ Eur J. Immunol. 24:2435.
24. Ullrich, S. E. 1994. Mechanisms involved in the systemic suppression of antigen-presenting cell function by UV irradiation. Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells J. Immunol. 152:3410.
25. Schmitt, D A , L Owen-Schaub, and S E Ullrich 1995 Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation. J. Immunol. 154:5114.
26. Germann, T , M. K. Gately, D. S. Schoenhaut, M. Lohoff, F. Mattner, S. Fischer, S.-C. Jin, E. Schmitt, and E. Ruhe. 1993. Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur J. Immunol. 23.1762.
27. Kubin, M , M. Kamoun, and G. Trinchieri. 1994. Interleukin-12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells J Exp. Med. 180:211.
28. Murphy, E. E., G. Terres, S. E Macatonia, C.-S Hsieh, J. Matton, L. Lanier, M Wysocka, G. Trinchieri, K. Murpha, and A. O'Garra 1994 B7 and IL-12 cooperate for proliferation and IFN-γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180 223