Prevention of normally occurring and deafferentation-induced neuronal death in chick brainstem auditory neurons by periodic blockade of AMPA/kainate receptors

Journal of Neuroscience

Volumn 17, Issue 12, 1997, Pages 4744-4751

  Solum, Derek ^a   Hughes, David ^a   Major, M Scott ^a   Parks, Thomas N ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Auditory system; CNQX; Cochlear nuclei; CPP; Glutamate; NBQX; Neuroprotection; Nucleus laminaris; Nucleus magnocellularis; Programmed cell death

Indexed keywords

4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; KAINIC ACID RECEPTOR;

ACOUSTIC NERVE FIBER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN STEM; CELL SURVIVAL; CHICKEN; COCHLEAR NUCLEUS; CONTROLLED STUDY; DEAFFERENTATION; EMBRYO; MAGNOCELLULAR NUCLEUS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PREVENTION; PRIORITY JOURNAL; RECEPTOR BLOCKING; THALAMUS INTRALAMINAR NUCLEUS;

EID: 0031010959     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-12-04744.1997     Document Type: Article

References (16)

1. Barry M, O'Donovan MJ (1987) The effects of excitatory amino acids and their antagonists on the generation of motor activity in the isolated chick spinal cord. Dev Brain Res 36:271-276.
2. Bettler B, Mulle C (1995) AMPA and kainate receptors. Neuropharmacology 34:123-139.
3. Bonhoeffer T (1996) Neurotrophins and activity-dependent development of the neocortex. Curr Opin Neurobiol 6:119-126.
4. Bredesen DE (1996) Keeping neurons alive: the molecular control of apoptosis. The Neuroscientist 2:181-190,211-216.
5. Carriedo SG, Yin HZ, Weiss JH (1966) Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro. J Neurosci 16:4069-4079.
6. Ciutat D, Esquerda JE, Caldero J (1994) Evidence for calcium regulation of spinal cord motoneuron death in the chick embryo in vivo. Dev Brain Res 86:167-179.
7. Clarke PGH, Oppenheim RW (1995) Neuron death in vertebrate development: in vivo methods. Methods Cell Biol 46:277-321.
8. Coggeshall RE, Lekan HE (1996) Methods for determining numbers ofcells and synapses: a case for more uniform standards of review. J Comp Neurol 354:6-15.
9. Collingridge G, Lester RAJ (1989) Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev 40:143-210.
10. Ernfors P, VanDeWater T, Loring J, Jaenisch R (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 14:1153-1164.
11. Ghosh A (1996) With an eye on neurotrophins. Curr Biol 6:130-133.
12. Haberecht MF, Redburn DA (1996) High levels of extracellular glutamate are present in retina during neonatal development. Neurochem Res 21:285-291.
13. Hafidi A, Moore T, Sanes DH (1996) Regional distribution of neurotrophin receptors in the developing auditory brainstem. J Comp Neurol 367:454-464.
14. Roberts MA, Brunso-Bechtold J, Oppenheim RW (1993) Both NMDA receptor agonists and antagonists increase cell death in ovo in chick spinal motoneurons. Soc Neurosci Abstr 19:440.
15. Rubel EW, Parks TN (1988) Organization and development of the avian brainstem auditory system. In: Auditory function: neurobiological bases of hearing (Edelman GM et al., eds), pp 3-92. New York: Wiley.
16. Rubel EW, Smith DJ, Miller LC (1976) Organization and development