Selective tight binding inhibitors of trypanosomal glyceraldehyde-3- phosphate dehydrogenase via structure-based drug design

Journal of Medicinal Chemistry

Volumn 41, Issue 24, 1998, Pages 4790-4799

  Aronov, Alex M ^a   Verlinde, Christophe L M J ^a   Hol, Wim G J ^a,b   Gelb, Michael H ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE DERIVATIVE; ENZYME INHIBITOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; ENZYME INHIBITION; LEISHMANIA MEXICANA; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

ADENOSINE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; LEISHMANIA MEXICANA; MODELS, MOLECULAR; NAD; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0032548073     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9802620     Document Type: Article

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