Effect of ω-conotoxin GVIA on noradrenaline release from postganglionic sympathetic neurones in rabbit aorta

Pharmacology and Toxicology

Volumn 86, Issue 1, 2000, Pages 30-35

  Nedergaard, Ove A ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; COCAINE; CORTICOSTEROID; NORADRENALIN; OMEGA CONOTOXIN GVIA;

ANIMAL TISSUE; AORTA; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; FEMALE; ISOLATED ARTERY; MALE; NERVE ENDING; NERVE FIBER MEMBRANE; NEUROTRANSMITTER UPTAKE; NONHUMAN; NORADRENALIN RELEASE; POSTGANGLIONIC NERVE; PRIORITY JOURNAL; RABBIT; SYMPATHETIC NERVE;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0033976118     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2000.pto860106.x     Document Type: Article

References (19)

1. Bleakman, D. & R. J. Miller: Regulation of calcium influx as a basis for modulation of neurotransmitter release. In: Neurotransmitter release and its modulation. Eds.: D.A. Powis & S.J. Brunn. Cambridge University Press, Cambridge, 1995, pp. 182-199.
2. Clasbrummel, B., H. Osswald & P. Illes: Inhibition of noradrenaline release by ω-conotoxin GVIA in the rat tail artery. Brit. J. Pharmacol. 1989, 98, 101-110.
3. De Luca, A., C. G. Li, M. J. Rand, J. J. Reid, P. Thaina & H. K. Wong-Dusting: Effects of ω-conotoxin GVIA on autonomic neuroeffector transmission in various tissues. Brit. J. Pharmacol. 1990, 101, 437-447.
4. El-Din, M. M. N. & K. U. Malik: Differential effect of ω-conotoxin on release of the adrenergic transmitter and the vasoconstrictor response to noradrenaline in the rat isolated kidney. Brit. J. Pharmacol. 1988, 94, 355-362.
5. Göthert, M. & G.J. Molderings: Mibefradil-and ω-conotoxin GVIA-induced inhibition of noradrenaline release from the sympathetic nerves of the human heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 1997, 356, 860-863.
6. 2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 1988, 239, 57-61.
7. Jensen, T. J. & O. A. Nedergaard: Modulation of norepinephrine release from sympathetic neurons of the rabbit aorta by prejunctional prostanoid receptors. J. Pharmacol. Exp. Therap. 291, 7-11.
8. Katz, B.: The release of neural transmitter substances. In: The Sherrington Lectures X. Liverpool University Press, Liverpool, England, 1969.
9. 2+ channel sub-types in peripheral efferent autonomic nerves. J. Aut. Pharmacol. 1996, 16, 229-241.
10. McCleskey, E. W., A. P. Fox, D. H. Feldman, L. J. Cruz, B. M. Olivera & R. W. Tsien: ω-Conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proc. Natl. Acad. Sci., USA, 1987, 84, 4327-4331.
11. Nedergaard, O. A.: Modulation by the muscarinic agonist McN-A-343 of noradrenaline release from vascular sympathetic neurones. J. Cardiovasc. Pharmacol. 1980, 2, 629-643.
12. Nedergaard, O. A.: Effect of ω-conotoxin GVIA on noradrenaline release from postganglionic sympathetic neurons in rabbit aorta. Naunyn-Schmiedeberg's Arch. Pharmacol. 1998, 358 (Suppl 1) R237.
13. 3H-noradrenaline released from rabbit aorta. Pharmacology & Toxicology 1987, 60, 333-336.
14. Nowycky, M. C., A. P. Fox & R. W. Tsien: Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 1985, 316, 440-443.
15. Olivera, B. M., J. M. McIntosh, L. J. Cruz, F. A. Luque & W. R. Gray: Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. Biochemistry 1984, 23, 5087-5090.
16. Olivera, B. M., G. P. Miljanich, J. Ramachandran & M. E. Adams: Calcium channel diversity and neurotransmitter release: the ω-conotoxins and ω-agatoxins. Annu. Rev. Biochem. 1994, 63, 823-867.
17. Pruneau, D. & J. A. Angus: ω-Conotoxin GVIA is a potent inhibitor of sympathetic neurogenic responses in rat small mesenteric arteries. Brit. J. Pharmacol. 1990, 100, 180-184.
18. Smith, A. B. & T. C. Cunnane: ω-Conotoxin GVIA-resistant neurotransmitter release in postganglionic sympathetic nerve terminals. Neurosci. 1996, 70, 817-824.
19. Wright, C. E. & J. A. Angus: Effects of N-, P- and Q-type neuronal calcium channel antagonists on mammalian peripheral neurotransmission. Brit. J. Pharmacol 1996, 119, 49-56.