Study of the nonresorptive phenotype of osteoclast-like cells from patients with malignant osteopetrosis: A new approach to investigating pathogenesis

Journal of Bone and Mineral Research

Volumn 15, Issue 2, 2000, Pages 352-360

  Flanagan, Adrienne M ^a,e   Sarma, Usha ^a   Steward, Colin G ^b   Vellodi, Ashok ^c   Horton, Michael A ^d  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b BRISTOL ROYAL HOSPITAL FOR CHILDREN   (United Kingdom)

^c GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Bone resorption; CD44; F actin ring; Osteoclast; Osteopetrosis

Indexed keywords

CALCITONIN RECEPTOR; F ACTIN; HERMES ANTIGEN; VITRONECTIN RECEPTOR;

ALBERS SCHOENBERG DISEASE; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BLOOD; BONE MARROW; CELL LINEAGE; CELL TYPE; COCULTURE; CONTROLLED STUDY; HISTOCHEMISTRY; HUMAN; HUMAN CELL; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PATHOGENESIS; PHENOTYPE; RAT; SCANNING ELECTRON MICROSCOPY;

EID: 0033975778     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2000.15.2.352     Document Type: Article

References (47)

1. Gerritsen JA, Vossen JM, van Loo IHG, Hermans J, Helfrich MH, Griscelli C, Fischer A 1994 Autosomal recessive osteopetrosis: Variability of findings at diagnosis and during the natural course. Pediatrics 93:247-253.
2. Gerritsen EJA, Vossen JM, Fasth A, Friedrich W, Morgan G, Padmos A, Vellodi A, Porras O, O'Meara A, Porta F, Bordigoni P, Cant A, Hermans J, Griscelli C, Fischer A 1994 Bone marrow transplantation for autosomal recessive osteopetrosis. J Pediatr 125:896-902.
3. Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, Martin TJ, Suda T 1988 Osteoblastic cells are involved in osteoclast formation. Endocrinology 123:2600-2602.
4. btsA58 transgenic mouse. Proc Natl Acad Sci USA 90:5578-5582.
5. Jimi E, Nakamura I, Amano H, Taguchi Y, Tsurukai T, Tamura M, Takahashi N, Suda T 1996 Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact. Endocrinology 137:2187-2190.
6. Yoshida H, Hayashi S-I, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S-I 1990 The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345:442-444.
7. Wiktor-Jedrzejczak W, Bartocci A, Ferrante AW Jr, Ahmed-Ansari A, Sell KW, Pollard JW, Stanley ER 1990 Total absence of colony-stimulating factor I in the macrophage-deficient osteopetrotic (op/op) mouse. Proc Natl Acad Sci USA 87:4828-4832.
8. Soriano P, Montgomery C, Geske R, Bradley A 1991 Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693-702.
9. Grigoriadis AE, Wang Z-Q, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF 1994 c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266:443-447.
10. Iotsova V, Caamano J, Loy J, Yang Y, Lewin A, Bravo R 1997 Osteopetrosis in mice lacking NF-κB1 and NF-κB2. Nat Med 3:1285-1289.
11. Tondravi MM, McKercher SR, Anderson K, Erdmann JM, Quiroz M, Maki R, Teitelbaum SL 1997 Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. Nature 386: 81-84.
12. Hodgkinson CA, Moore KJ, Nakayama A, Steingrimsson E, Copeland NG, Jenkins NA, Arnhelter H 1993 Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74:395-404.
13. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gregg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ 1997 Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89:309-319.
14. Felix R, Cecchini MG, Fleisch H 1990 Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse. Endocrinology 127:2592-2594.
15. Kodama H, Yamasaki A, Nose M, Niida S, Ohgame Y, Abe M, Kumegawa M, Suda T 1991 Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor. J Exp Med 173:269-272.
16. Takahashi N, Udagawa N, Akatsu T, Tanaka H, Isogai Y, Suda T 1991 Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells. Endocrinology 128:1792-1796.
17. Sly WS, Hewett-Emmett D, Whyte MP, Yu Y-SL, Tashjian RE 1983 Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification. Proc Natl Acad Sci USA 80:2752-2756.
18. Gelb BD, Shi GP, Chapman HA, Desnick RJ 1996 Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 273:1236-1238.
19. Cournot G, Trubert-Thil CL, Petrovic M, Boyle A, Cormier C, Girault D, Fischer A, Garabedian M 1992 Mineral metabolism in infants with malignant osteopetrosis: heterogeneity in plasma 1, 25-dihydroxyvitamin D levels and bone histology. J Bone Miner Res 7:1-10.
20. Lajeunesse D, Busque L, Menard P, Brunette MG, Bonny Y 1996 Demonstration of an osteoblast defect in two cases of human malignant osteopetrosis. J Clin Invest 98:1835-1842.
21. Fujikawa Y, Quinn JMW, Sabokbar A, McGee JOD, Athanasou NA 1996 The human osteoclast precursor circulates in the monocyte fraction. Endocrinology 137:4058-4060.
22. Massey HM, Flanagan AM 1999 Human osteoclasts derive from CD14-positive monocytes. Br J Haematol 106:167-170.
23. Flanagan AM, Sarma U 1998 In vitro models for osteoclast recruitment. In: Arnett TR, Henderson B (eds.) Methods in Bone Biology. Chapman & Hall, London, U.K., pp. 50-60.
24. Nicholson GC, Horton MA, Sexton PM, D'Santos CS, Moseley JM, Kemp BE, Pringle JAS, Martin TJ 1987 Calcitonin receptors of human osteoclastoma. Horm Metab Res 19:585-589.
25. Horton MA, Chambers TJ 1986 Human osteoclast-specific antigens are expressed by osteoclasts in a wide range of non-human species. Br J Exp Pathol 67:95-104.
26. Davies J, Warwick J, Tutty N, Philip R, Helfrich M, Horton M 1989 The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol 109:1817-1826.
27. Sarma U, Flanagan AM 1996 Macrophage-colony stimulating factor (M-CSF) induces substantial osteoclast formation in human bone-marrow cultures. Blood 88:2531-2540.
28. Vaananen HK, Horton M 1995 Review: The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure. J Cell Sci 108:2729-2732.
29. Lakkakorpi PT, Horton MA, Helfrich MH, Karhukorpi E-K, Väänänen HK 1991 Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface. J Cell Biol 115:1179-1186.
30. Jaffe HL 1976 Metabolic, Degenerative, and Inflammatory Diseases of Bone and Joints. Lea and Febiger, Philadelphia, PA, U.S.A., pp. 178-192.
31. Morrison MS, Arnett TR 1998 pH effects on osteoclast formation and activation. Bone 22:305.
32. Lader CS, Scopes J, Horton MA, Flanagan AM 1999 Human osteoclasts generated with soluble TRANCE - Differences from stromal cell-based culture systems. J Bone Miner Res 14:1033.
33. Athanasou NA, Quinn J 1990 Immunophenotypic differences between osteoclasts and macrophage polykaryons: Immunohistochemical distinction and implications for osteoclast ontogeny and function. J Clin Pathol 43:997-1003.
34. Hughes DE, Salter DM, Simpson R 1994 CD44 expression in human bone: A novel marker of osteocytic differentiation. J Bone Miner Res 9:39-44.
35. Higuchi S, Tabata N, Tajima M, Ito M, Tsurudome M, Sudo A, Uchida A, Ito Y 1998 Induction of human osteoclast-like cells by treatment of blood monocytes with anti-fusion regulatory protein-1/CD98 monoclonal antibodies. J Bone Miner Res 13:44-49.
36. Lesley J, Hyman R, Kincade P 1993 CD44 and its interaction with extracellular matrix. Adv Immunol 54:271-335.
37. Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, Kundig T, Wakeham A, Shahinian A, Catzavelos C, Rak J, Furlonger C, Zakarian A, Simard JJL, Ohashi PS, Paige CJ, Gutierrez-Ramos JC, Mak TW 1997 CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90:2217-2233.
38. Udagawa N, Takahashi N, Sasaki T, Akatsu T, Tanaka S, Tamura T, Tanaka H, Moriyama Y, Futai M, Kanehisa J, Vaananen K, Suda T 1992 Failure of bone resorption in osteosclerotic (oc/oc) mice is due to a defect in osteoclast progenitors but not in the local microenvironment. In: Cohn DV, Gennari C, Tashjian AHJ (eds.) Calcium Regulating Hormones and Bone Metabolism. Elsevier, Amsterdam, the Netherlands, pp. 151-156.
39. Nakamura I, Takahashi N, Udagawa N, Moriyama Y, Kurokawa T, Jimi E, Sasaki T, Suda T 1997 Lack of vacuolar proton ATPase association with the cytoskeleton in osteoclasts of osteosclerotic (oc/oc) mice. FEBS Lett 401:207-212.
40. Boyce BF, Yoneda T, Lowe C, Soriano P, Mundy GR 1992 Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J Clin Invest 90:1622-1627.
41. Lowe C, Yoneda T, Boyce BF, Chen H, Mundy GR, Soriano P 1993 Osteopetrosis in src-deficient mice is due to an autonomous defect of osteoclasts. Proc Natl Acad Sci USA 90:4485-4489.
42. Cas is involved in actin organization in osteoclasts. J Biol Chem 273:11144-11149.
43. 3 integrin, and phosphorylated by Src kinase. J Clin.Invest 102:881-892.
44. Bernard F, Casanova J-L, Cournot G, Jabado N, Peake J, Jauliac S, Fischer A, Hivroz C 1998 The protein tyrosine kinase p60c-Src is not implicated in the pathogenesis of the human autosomal recessive form of osteopetrosis: A study of 13 children. J Pediatr 133:537-543.
45. Hall TJ, Schaeublin M, Jeker H, Fuller K, Chambers TJ 1995 The role of reactive oxygen intermediates in osteoclastic bone resorption. Biochem Biophys Res Comm 207:280-287.
46. Reeves JD, August CS, Humbert JR, Weston WL 1979 Host defense in infantile osteopetrosis. Pediatrics 64:202-206.
47. Beard CJ, Key L, Newburger PE, Ezekowitz RAB, Arceci R, Miller B, Proto P, Ryan T, Anast C, Simons ER 1986 Neutrophil defect associated with malignant infantile osteopetrosis. J Lab Clin Med 108:498-505.