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An excellent overview of the state of the art in both animal and plant pathosystems.
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Stevens C., Bennett M.A., Athanassopoulos E., Tsiamis G., Taylor J.D., Mansfield J.W. Sequence variation in alleles of the avirulence gene avrPphE.R2 from Pseudomonas syringae pv. phaseolicola lead to a loss of recognition of the AvrPphE protein with bean cells and a gain in cultivar-specific virulence. Mol Microbiol. 29:1998;165-177.
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16
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This, and related screens, will roll Arabidopsis genetics into the next phase of development with respect to plant defense response. Saturation mutatgenesis is within reach.
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McNellis T.W., Mudgett M.B., Li K., Aoyama T., Horvath D., Chua N-H., Staskawicz B.J. Glucocorticoid-inducible expression of a bacterial avirulence gene in transgenic Arabidopsis thaliana induces hypersensitive cell death. Plant J. 14:1998;247-258. This, and related screens, will roll Arabidopsis genetics into the next phase of development with respect to plant defense response. Saturation mutatgenesis is within reach.
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17
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18
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0344948147
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Expression of a single, host-specific, bacterial pathogenicity gene in plant cells elicits division, enlargement, and cell death
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An important addition to the examples of how Type III effectors manipulate host response.
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Duan Y.P., Castaneda A., Zhao G., Erdos G., Gabriel D.W. Expression of a single, host-specific, bacterial pathogenicity gene in plant cells elicits division, enlargement, and cell death. Mol Plant-Microbe Interact. 12:1999;556-560. An important addition to the examples of how Type III effectors manipulate host response.
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Duan, Y.P.1
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Identification of a pathogenicity island, which contains genes for virulence and avrulence, on a large native plasmid in the bean pathogen Pseudomonas syringae pathovar phaseolicola
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A landmark paper which defines a suite of mix and match Type III effectors in a pathogenicity island embedded in a larger plasmid. Some of these effectors double as triggers of host disease resistance, and some function to inhibit avirulence functions in the bacterial chromosome.
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Jackson R.W., Athanassopoulos E., Tsiamis G., Mansfield J.W., Sesma A., Arnold D.L., Gibbon M.J., Murillo J., Taylor J.D., Vivian A. Identification of a pathogenicity island, which contains genes for virulence and avrulence, on a large native plasmid in the bean pathogen Pseudomonas syringae pathovar phaseolicola. Proc Natl Acad Sci USA. 96:1999;10875-10880. A landmark paper which defines a suite of mix and match Type III effectors in a pathogenicity island embedded in a larger plasmid. Some of these effectors double as triggers of host disease resistance, and some function to inhibit avirulence functions in the bacterial chromosome.
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30
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•], demonstrates that Type III effectors can be secreted by heterologous hosts. Does this presage the finding of heterologous transfer of effectors between pathogens of the two kingdoms?
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33
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The Avr (effector) proteins HrmA (HopPsyA) and AvrPto are secreted in culture from Pseudomonas syringae pathovars via the Hrp (type III) protein secretion system in a temperature- And pH-sensitive manner
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van Dijk K., Fouts D., Rehm A., Hill A., Collmer A., Alfano J. The Avr (effector) proteins HrmA (HopPsyA) and AvrPto are secreted in culture from Pseudomonas syringae pathovars via the Hrp (type III) protein secretion system in a temperature- and pH-sensitive manner. J Bacteriol. 181:1999;4790-4797.
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34
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AvrRpt2 is proteolytically cleaved by a host cytoplasmic protease. Is this sufficient evidence for translocation?
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Mudgett, M.1
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37
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0033197509
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The C terminus of AvrXa10 can be replaced by the transcriptional activation domain of VP16 from the herpes simplex virus
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If this Type III effector is a transcriptional activator, then what are the targets? Looks like a DNA array experiment waiting to happen.
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Zhu W., Yang B., Kurata N., Johnson L.B., White F.F. The C terminus of AvrXa10 can be replaced by the transcriptional activation domain of VP16 from the herpes simplex virus. Plant Cell. 11:1999;1665-1674. If this Type III effector is a transcriptional activator, then what are the targets? Looks like a DNA array experiment waiting to happen.
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Zhu, W.1
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40
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The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response
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Tomato Prf is a member of the leucine-rich repeat class of plant disease resistance genes and lies embedded within the Pto kinase gene cluster
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Salmeron J.M., Oldroyd G.E.D., Rommens C.M.T., Scofield S.R., Kim H-S., Lavelle D.T., Dahlbeck D., Staskawicz B.J. Tomato Prf is a member of the leucine-rich repeat class of plant disease resistance genes and lies embedded within the Pto kinase gene cluster. Cell. 86:1996;123-133.
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46
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47
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