Effects of mycophenolic acid on human renal proximal and distal tubular cells in vitro

Nephrology Dialysis Transplantation

Volumn 15, Issue 2, 2000, Pages 184-190

  Baer, Patrick C ^a   Gauer, Stefan ^a   Hauser, Ingeborg A ^a   Scherberich, Jürgen E ^b   Geiger, Helmut ^a  

^a GOETHE UNIVERSITY   (Germany)

^b EKN Clinical Neuropsychology Research Group   (Germany)

Author keywords

Distal tubule; Epithelial cells; Human; Mycophenolic acid; Proliferation; Proximal tubule

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; GUANOSINE; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MYCOPHENOLIC ACID; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; KIDNEY DISTAL TUBULE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION;

EID: 0033967634     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/15.2.184     Document Type: Article

References (42)

1. The Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group. A blinded, randomized clinical trial of the mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation. Transplant 1996; 61: 1029-1037
2. Vanrenterghem Y. The use of mycophenolate mofetil (Cellcept) in renal transplantation. Nephron 1997; 76: 392-399
3. Sintchak MD, Fleming MA, Futer O et al. Structure and mechanisms of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell 1996; 85: 921-930
4. Allison AC, Hovi WJ, Watts RW, Webster AD. The role of de novo purine synthesis in lymphocyte transformation. Cibu Found Symp 1977; 48: 207-224
5. Allison AC, Eugui EM. Preferential suppression of lymphocyte proliferation by mycophenolic acid and predict long-term effects of mycophenolate mofetil in transplantation. Transplant Proc 1994; 26: 3205-3219
6. Allison AC, Eugui EM, Sollinger HW. Mycophenolate mofetil (RS-61443): mechanisms of action and effects in transplantation. Transplant Rev 1993; 7: 129-139
7. Laurent AF, Dumont S, Poindron P, Muller CD. Mycophenolic acid suppresses protein N-linked glycosylation in human monocytcs and their adhesion to endothelial cells and to some substrates. Exp Hematol 1996; 24: 59-67
8. Pattison J, Nelson PJ, Huie P. RANTES chemokine expression in cell-mediated transplant rejection of the kidney. Lancet 1994; 343: 209-211
9. Andersen CB, Blaehr H, Ladefoged S, Larsen S. Expression of the intercellular adhesion molecule-1 (ICAM-1) in human renal allografts and cultured human tubular cells. Nephrol Dial Transplant 1992; 7: 147-154
10. Bishop GA, Hall BM, Suranyi MG, Tiller DJ, Horvath JS, Duggin GG. Expression of HLA antigens on renal tubular cells in culture I. Transplantation 1986; 42: 671-678
11. Nelson PJ, Kim HT, Manning WC, Goralski TJ, Krensky AM. Genomic organization and transcriptional regulation of the RANTES chemokine gene. J Immunol 1993; 151: 2601-2612
12. Jevnikar AM, Wuthrich RP, Takei F et al. Differing regulation and function of ICAM-1 and class II antigens of renal tubular cells. Kidney Int 1990; 38: 417-425
13. Wuthrich RP, Glimcher LH, Yui MA, Jevnikar AM, Dumas SE, Kelley VE. MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Kidney Int 1990; 37: 783-792
14. Deckers JGM, van der Woude FJ, van der Kooij SW, Daha MR. Synergistic effect of IL-1α, IFN-gamma, and TNF-α on RANTES production by human renal tubular epithelial cells in vitro. J Am Soc Nephrol 1998; 9: 194-202
15. Baer PC, Nockher WA, Haase W, Scherberich JE. Isolation of proximal and distal tubule cells from human kidney by immunomagnetic separation. Kidney Int 1997; 52: 1321-1331
16. Baer PC, Tunn UW, Nunez G, Scherberich JE, Geiger H. Transdifferentiation of distal but not proximal tubular epithelial cells from human kidney in culture. Exp Nephrol 1999; 7: 306
17. Blaheta RA, Franz M, Auth MKH, Wenisch HJC, Markus BH. A rapid non-radioactive fluorescence assay for the measurement of both cell number and proliferation. J Immunol Meth 1991; 142: 199-206
18. Tullius SG, Volk HD, Bechstein WO, Neuhaus P. Biologie der chronischen Abstoβung. Transplantationsmedizin 1997; 9: 96-104
19. Heeman U, Azuma H, Schmid C, Phillips T, Tilney N. Effects of mycophenolic acid mofetil on acute rejection of kidney allografts in rats. Clin Nephrol 1996; 45: 355-357
20. Lui SL, Ramassar V, Urmson J, Halloran PF. Mycophenolate mofetil reduces production of interferon-dependent histocompatibility complex induction during allograft rejection, probably by limiting clonal expansion. Transplant Immunol 1998; 6: 23-32
21. Sollinger HW. Mycophenolate mofetil. Kidney Int 1990; 52: 14-17
22. CellCept® Mycophenolatmofetil. Hofmann-LaRoche, Grenzach-Wyhlen, 1996
23. Allison AC, Eugui EM. Mycophenolate mofetil, a rationally designed immunosuppressive drug. Clin Transplant 1993; 7: 96-112
24. Allison AC, Almquist SJ, Muller CJ, Eugui EM. In vitro immunosuppressive effects of mycophenolic acid and an ester pro-drug, RS-61443. Transplant Proc 1991; 23: 10-14
25. Mohacsi PJ, Tuller D, Hullinger B, Wijngaard PL. Different inhibitory effects of immunosuppressive drugs on human and rat aortic smooth muscle and endothelial cell proliferation stimulated by platelet-derived growth factor or endothelial cell growth factor. J Heart Lung Transplant 1997; 16: 484-492
26. Hauser IA, Renders L, Radeke HH, Sterzel B, Goppelt-Struebe M. Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosine depletion. Nephrol Dial Transplant 1999; 14: 58-63
27. Eugui EM, Almquist SJ, Muller CD, Allison AC. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion. Scand J Immunol 1991; 33: 161-173
28. Simmons WD, Rayhill SC, Sollinger HW. Preliminary risk-benefit assessment of mycophenoliate mofetil in transplant rejection. Drug Safety 1997; 17: 75-92
29. Fairchild RL, Van Buskirk AM, Kondo T, Wakely ME, Orosz CG. Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts. Transplantation 1997; 63: 1807-1812
30. Nagano H, Nadeau KC, Takaga M, Kusaka M, Tilney NL. Sequential cellular and molecular kinetics in acutely rejecting renal allografts in rats. Transplantation 1997; 63: 1101-1108
31. Robertson H, Wheeler J, Morley AR, Booth TA, Talbot D, Kirby JA. Beta-chemokine expression and distribution in paraffin-embedded transplant renal biopsy sections: analysis by scanning laser confocal microscopy. Histochem Cell Biol 1998; 110: 207-213
32. Stellato C, Beck LA, Gorgone GA et al. Expression of the chemokine RANTES by a human bronchial epithelial cell line. Modulation by cytokines and glucocorticoids. J Immunol 1995; 155: 410-418
33. Kwon OJ, Jose PJ, Robbins RA, Schall TJ, Williams TJ, Barnes PJ. Glucocorticoid inhibition of RANTES in human lung epithelial cells. Am J Resp Cell Mol Biol 1995; 12: 488-496
34. Haberstroh U, Stilo K, Pocock J et al. L-Arginine suppresses lipopolysaccharide-induced expression of RANTES in glomeruli. J Am Soc Nephrol 1998; 9: 203-210
35. Senda M, DeLustro B, Eugui E, Natsumeda Y. Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat endothelial cells. Transplantation 1995; 60: 1143-1148
36. Scherberich JE, Nockher WA, Baer PC. Cross-talk between activated tubular epithelia of human kidney and monocytes: a basis for target cell-specific pharmacotherapy? Nephrol Dial Transplant 1999; 14 [Suppl. 4]: 8-10
37. Faul RJ, Russ GR. Tubular expression of intercellular adhesion molecule-1 during renal allograft rejection. Transplantation 1989; 48: 226-230
38. Benson EM, Colvin RB, Russell PS. Induction of 1a antigens in murine renal transplants. J Immunol 1985; 134: 7-9
39. Allison AC, Eugui EM. Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF). Clin Transplant 1996; 10: 77-84
40. Weigel G, Bertalanffy P, Dubsky P, Griesmacher A, Wolner E. Mycophenolic acid influences Thelper2 (Th2) cytokine induced expression of intercellular cell adhesion molecule-1 (ICAM-1) on human endothelial cells. Clin Chem Lab Med 1999; 37: 253
41. Hauser IA, Johnson DR, Thevenod F, Goppelt-Struebe M. Effect of mycophenolic acid on TNFα-induced expression of cell adhesion molecules in human venous endothelial cells in vitro. Br J Pharmacol 1997; 122: 1315-1322
42. Thomson AW, Woo J, Yao GZ, Todo S, Starzl TE, Zeevi A. Effects of combined administration of FK506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures. Transplant Immunol 1993; 1: 146-150