Effects of mycophenolic acid mofetil on acute rejection of kidney allografts in rats

Clinical Nephrology

Volumn 45, Issue 5, 1996, Pages 355-357

  Heemann, U ^a   Azuma, H ^b   Schmid, C ^a   Philipp, T ^a   Tilney, N ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Acute rejection; Adhesion molecules; Mycophenolic acid mofetil

Indexed keywords

CELL ADHESION MOLECULE; IMMUNOSUPPRESSIVE AGENT; INOSINATE DEHYDROGENASE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PURINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATROPHY; CELL INFILTRATION; CONTROLLED STUDY; ENZYME INHIBITION; GRAFT REJECTION; IMMUNOHISTOLOGY; KIDNEY TRANSPLANTATION; KIDNEY TUBULE; MACROPHAGE; MALE; NONHUMAN; PURINE METABOLISM; RAT; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL ADHESION MOLECULES; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; IMP DEHYDROGENASE; INTEGRIN ALPHA4BETA1; INTEGRINS; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY; KIDNEY TRANSPLANTATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; MYCOPHENOLIC ACID; RATS; RATS, INBRED BN; RATS, INBRED LEW; RECEPTORS, LYMPHOCYTE HOMING; TRANSPLANTATION, HOMOLOGOUS;

EID: 0029875842     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Allison AC, Eugui EM 1994 Preferential suppression of lymphocyte proliferation by MMF and predicted long-term effects of mycophenolate mofetil in transplantation. Transplant Proc 26: 3205-3210
2. Allison AC, Kowalski WJ, Muller CJ, Waters RV, Eugui EM 1993 MMF and brequinar, inhibitors of purine and pyrimidine synthesis, block the glycosylation of adhesion molecules. Transplant Proc 25 (3 Suppl): 67-70
3. European Mycophenolate Mofetil Cooperative Study Group 1995 Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 3345: 1321-1325
4. Franklin TJ, Cook JM 1969 The inhibition of nucleic acid synthesis by MMF. Biochem J 113: 515-524
5. Heemann UW, Tullius SG, Azuma H, Kupiec-Weglinsky JW, Tilney NL 1994 Adhesion molecules and transplantation. Ann Surg 219: 4-12
6. Morris RE, Wang J, Blum JR, Flavin T, Murphy MP, Almquist SJ, Chu N, Tam YL, Kaloostian M, Allison AC 1991 Immunosuppressive effects of the morpholinoethyl ester of MMF (RS-61443) in rat and nonhuman primate recipients of heart allografts. Transplant Proc 23 (2 Suppl 2): 19-25
7. Young CJ, Sollinger HW 1994 RS-6143: a new immunosuppressive agent. Transplant Proc 26: 3144-3146