Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: Comparison between Alzheimer's diseased and control brains

Neuroscience Letters

Volumn 281, Issue 1, 2000, Pages 37-40

  Malherbe, Pari ^a   Faull, Richard L M ^b   Richards, J Grayson ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b THE UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Alzheimer's disease; Bleomycin hydrolase; Cysteine protease; In situ hybridization; mRNA

Indexed keywords

BLEOMYCIN HYDROLASE; CYSTEINE PROTEINASE; MESSENGER RNA;

ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME LOCALIZATION; GENETIC POLYMORPHISM; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; NEUROLOGIC DISEASE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; CYSTEINE ENDOPEPTIDASES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IN SITU HYBRIDIZATION; MALE; RNA, MESSENGER;

EID: 0033967024     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)00802-8     Document Type: Article

References (20)

1. Abraham C.R., Chang T., Feldman M., Lu R.M., McGraw W. Identification and characterization of a cysteine proteinase from AD brain as a candidate β-secretase: binding and degradation properties for APP (Abstract 8.11), Soc. Neurosci. 23:1997;5.
2. Berti P.J., Storer A.C. Alignment/phylogeny of the papain superfamily of cysteine proteases. J. Mol. Biol. 246:1995;273-283.
3. Chang T., Abraham C.R. A novel brain cysteine protease forms an SDS stable complex with the β-amyloid precursor protein. Ann. N.Y. Acad. Sci. 777:1996;183-188.
4. Chapot-Chartier M.P., Rul F., Nardi M., Gripon J.C. Gene cloning and characterization of PepC, a cysteine aminopeptidase from Streptococcus thermophilus, with sequence similarity to the eucaryotic bleomycin hydrolase. Eur. J. Biochem. 224:1994;497-506.
5. Enenkel C., Wolf D.H. BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase. J. Biol. Chem. 268:1993;7036-7043.
6. Farrer L.A., Abraham C.R., Haines J.L., Rogaeva E.A., Song Y., McGraw W.T., Brindle N., Premkumar S., Scott W.K., Yamaoka L.H., Saunders A.M., Roses A.D., Auerbach S.A., Sorbi S., Duara R., Pericak-Vance M.A., St George-Hyslop P.H. Association between bleomycin hydrolase and Alzheimer's disease in Caucasians. Ann. Neurol. 44:1998;808-811.
7. Ferrando A.A., Velasco G., Campo E., Lopez-Otin C. Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance. Cancer Res. 56:1996;1746-1750.
8. Ferrando A.A., Pendas A.M., Llano E., Velasco G., Lidereau R., Lopez-Otin C. Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase. J. Biol. Chem. 272:1997;33298-33304.
9. Koldamova R.P., Lefterov I.M., Gadjeva V.G., Lazo J.S. Essential binding and functional domains of human bleomycin hydrolase. Biochemistry. 37:1998;2282-2290.
10. Koldamova R.P., Lefterov I.M., DiSabella M.T., Lazo J.S. An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9. Mol. Pharmacol. 54:1998;954-961.
11. Malherbe P., Köhler Ch., Da Prada M., Lang G., Kiefer V., Schwarcz R., Lahm H.-W., Cesura A.M. Molecular cloning and functional expression of human 3-hydroxyanthranilic acid dioxygenase. J. Biol. Chem. 269:1994;13792-13797.
12. Montoya, S.E., Ferrell, R.E. and Lazo, J.S., Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase. Cancer Res., 57 (19) 4191-4195.
13. Montoya S.E., Aston C.E., DeKosky S.T., Kamboh M.I., Lazo J.S., Ferrell R.E. Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease. Nature Genet. 18:1998;211-212.
14. Namba Y., Ouchi Y., Asada T., Hattori H., Ueki A., Ikeda K. Lack of association between bleomycin hydrolase gene polymorphism and Alzheimer's disease in Japanese people. Ann. Neurol. 46:1999;136-137.
15. Namba Y., Ouchi Y., Takeda A., Ueki A., Ikeda K. Bleomycin hydrolase immunoreactivity in senile plaque in the brains of patients with Alzheimer's disease. Brain Res. 830:1999;200-202.
16. O'Farrell P.A., Gonzalez F., Zheng W., Johnston S.A., Joshua-Tor L. Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. Structure Fold Des. 7:1999;619-627.
17. Saura J., Bleuel Z., Ulrich J., Mendelowitsch A., Chen K., Shih J.C., Malherbe P., Da Prada M., Richards J.G. Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry. Neuroscience. 70:1996;755-774.
18. Sebti S.M., DeLeon J.C., Lazo J.S. Purification, characterization, and amino acid composition of rabbit pulmonary bleomycin hydrolase. Biochemistry. 26:1987;4213-4219.
19. Takeda A., Masuda Y., Yamamoto T., Hirabayashi T., Nakamura Y., Nakaya K. Cloning and analysis of cDNA encoding rat bleomycin hydrolase, a DNA-binding cysteine protease. J. Biochem. (Tokyo). 120:1996;353-359.
20. Yanker B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 16:1996;921-932.