An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9

Molecular Pharmacology

Volumn 54, Issue 6, 1998, Pages 954-961

  Koldamova, Radosveta P ^a   Lefterov, Iliya M ^a   DiSabella, Marc T ^a   Lazo, John S ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; BLEOMYCIN HYDROLASE; CYSTEINE PROTEINASE; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; DELETION MUTANT; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; GENETIC CONSERVATION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; SITE DIRECTED MUTAGENESIS;

EID: 0032409008     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.6.954     Document Type: Article

References (7)

1. Berti PJ and Storer AC (1995) Alignment/phytogeny of the papain superfamily of cysteine proteases. J Mol Biol 246:273-283.
2. Bromme D, Rossi AB, Smeekens SP, Anderson DC, and Payan DG (1996) Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. Biochemistry 35:6706-6714.
3. Chapman HA, Riese RJ, and Shi GP (1997) Emerging roles for cysteine proteases in human biology. Annu Rev Physiol 59:63-88.
4. Enenkel C and Wolf DH (1993) BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase. J Biol Chem 268:7036-7043.
5. Yasugi T and Howley PM (1996) Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9. Nucleic Acids Res 24:2005-2010.
6. Zheng W, Johnston SA, and Joshua-Tor L (1998) The unusual active site of Gal6/ bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Cell 93:103-109.
7. Zheng W, Xu EH, and Johnston SA (1997) The cysteine-peptidase bleomycin hydrolase is a member of the galactose regulon in yeast. J Biol Chem 272:30350-30355.