Development of a plasma high-performance liquid chromatographic assay for LY303366, a lipopeptide antifungal agent, and its application in a dog pharmacokinetic study

Journal of Chromatography B: Biomedical Applications

Volumn 695, Issue 2, 1997, Pages 381-387

  Zornes, L L ^a   Stratford, R E ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Echinocandin B; Lipoeptides; LY303366

Indexed keywords

ANIDULAFUNGIN; ANTIFUNGAL AGENT; ECHINOCANDIN B DERIVATIVE; LIPOPEPTIDE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG DETERMINATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RABBIT; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; STEADY STATE; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY;

ADMINISTRATION, ORAL; ANIMALS; ANTIBIOTICS, ANTIFUNGAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; INJECTIONS, INTRAVENOUS; PEPTIDES, CYCLIC; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0030739799     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(97)00184-9     Document Type: Article

References (5)

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2. W.L. Current, C.J. Boylan, RP. Raab, Anti-Pneumocystis Activity of LY303366 and Other Echinocandin B Analogs, Presented at the 33rd ICAAC, New Orleans, LA, 1993, Abstract 368.
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5. L. Zornes, R. Stratford, M. Novilla, D. Turner, C. Boylan, B. Boyll, T. Butler, Y. Lin, D. Zeckner, W. Turner, W. Current, Single Dose i.v. Bolus and Oral Administration Pharmacokinetics of LY303366, a New Lipopeptide Antifungal Agent Related to Echinocandin B, in Female Lewis Rats and Beagle Dogs, Presented at the 33rd ICAAC, New Orleans, LA, 1993, Abstract 370.