The rational construction of an antibody against cystatin: Lessons from the crystal structure of an artificial F(ab) fragment

Journal of Molecular Biology

Volumn 268, Issue 5, 1997, Pages 934-951

  Schiweck, Wolfram ^a,b   Skerra, Arne ^b  

^a MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^b DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Antigen binding; Computer modelling; Immunoglobulin; Protein engineering; X ray crystallography

Indexed keywords

ANTIBODY; CYSTATIN; IMMUNOGLOBULIN F(AB) FRAGMENT; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ANTIBODY PRODUCTION; ANTIBODY STRUCTURE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ESCHERICHIA COLI; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; R FACTOR;

EID: 0031584270     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1006     Document Type: Article

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