Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action

Pain

Volumn 85, Issue 1-2, 2000, Pages 217-224

  Koppert, Wolfgang ^a   Ostermeier, Nikola ^b   Sittl, Reinhard ^a   Weidner, Christian ^a   Schmelz, Martin ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Nuremberg City Hospital   (Germany)

Author keywords

Allodynia; Bier block; Capsaicin; Flare; Intravenous; Lidocaine; Pain

Indexed keywords

CAPSAICIN; LIDOCAINE; SODIUM CHANNEL BLOCKING AGENT;

ALLODYNIA; ANESTHESIA MECHANISM; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; HYPERALGESIA; PAIN; PAIN ASSESSMENT; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGIONAL ANESTHESIA;

ADULT; ANESTHESIA, CONDUCTION; ANESTHETICS, LOCAL; AXONS; CAPSAICIN; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERALGESIA; INJECTIONS, INTRAVENOUS; LASER-DOPPLER FLOWMETRY; LIDOCAINE; MALE; MIDDLE AGED; PAIN MEASUREMENT;

EID: 0033963154     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(99)00268-7     Document Type: Article

References (51)

1. Abram S.E., Yaksh T.L. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology. 80:1994;383-391.
2. Akopian A.N., Sivilotti L., Wood J.N. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature. 379:1996;257-262.
3. Akopian A.N., Souslova V., England S., Okuse K., Ogata J., Ure J., Smith A., Kerr B.J., McMahon S.B., Boyce S., Hill R., Stafna L.C., Dickenson A.H., Wood J.N. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci. 2:1999;541-548.
4. Beck P.W., Handwerker H.O., Zimmermann M. Nervous outflow from the cat's foot during noxious radiant heat stimulation. Brain Res. 67:1974;373-386.
5. Chabal C., Jacobson L., Mariano A., Chaney E., Britell C.W. The use of oral mexiletine for the treatment of pain after peripheral nerve injury. Anesthesiology. 76:1992;513-517.
6. Chaplan S.R., Bach F.W., Shafer S.L., Yaksh T.L. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats. Anesthesiology. 83:1995;775-785.
7. Dib-Hajj S.D., Tyrrell L., Black J.A., Waxman S.G. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. Proc Natl Acad Sci USA. 95:1998;8963-8968.
8. Ferrante F.M., Paggioli J., Cherukuri S., Arthur G.R. The analgesic response to intravenous lidocaine in the treatment of neuropathic pain. Anesth Analg. 82:1996;91-97.
9. Galer B.S., Miller K.V., Rowbotham M.C. Response to intravenous lidocaine infusion differs based on clinical diagnosis and site of nervous system injury. Neurology. 43:1993;1233-1235.
10. + current in nociceptors. Proc Natl Acad Sci USA. 93:1996;1108-1112.
11. Greiner T., Nischik M., Schmelz M., Forster C., Handwerker H.O. Neurogenic flare responses are heterogeneous in superficial and deep layers of human skin. Neurosci Lett. 185:1995;33-36.
12. Guinard J.P., Carpenter R.L., Morell R.C. Effect of local anesthetic concentration on capillary blood flow in human skin. Reg Anesth. 17:1992;317-321.
13. Johns R.A., DiFazio C.A., Longnecker D.E. Lidocaine constricts or dilates rat arterioles in a dose-dependent manner. Anesthesiology. 62:1985;141-144.
14. Kalman S., Bjorhn K.C., Tholen E.K., Lisander B. Mepivacaine as an intravenous regional block interferes with reactive hyperemia and decreases steady-state blood flow. Reg Anesth. 22:1997;552-556.
15. Kalman S., Linderfalk C., Wardell K., Eintrei C., Lisander B. Differential effect on vasodilatation and pain after intradermal capsaicin in humans during decay of intravenous regional anesthesia with mepivacaine. Reg Anesth Pain Med. 23:1998;402-408.
16. Kastrup J., Petersen P., Dejgard A., Angelo H.R., Hilsted J. Intravenous lidocaine infusion-a new treatment of chronic painful diabetic neuropathy? Pain. 28:1987;69-75.
17. Koltzenburg M., Torebjörk H.E., Wahren L.K. Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain. 117:1994;579-591.
18. Koppert W., Zeck S., Sittl R., Likar R., Knoll R., Schmelz M. Low-dose lidocaine suppresses experimentally induced hyperalgesia in humans. Anesthesiology. 89:1998;1345-1353.
19. Koppert W., Ostermeier N., Weidner C., Sittl R., Schmelz M. Effect of systemic lidocaine on capsaicin-induced pain, flare and hyperalgesia, Anesthesiology. 89:(Suppl 3):1998;A1166.
20. Koppert W., Likar R., Geisslinger G., Zeck S., Schmelz M., Sittl R. Peripheral antihyperalgesic effect of morphine to heat, but not mechanical, stimulation in healthy volunteers after ultraviolet-B irradiation. Anesth Analg. 88:1999;117-122.
21. Kress M., Koltzenburg M., Reeh P.W., Handwerker H.O. Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro. J Neurophysiol. 68:1992;581-595.
22. LaMotte R.H., Thalhammer J.G., Torebjörk H.E., Robinson C.J. Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. J Neurosci. 2:1982;765-781.
23. LaMotte R.H., Shain C.N., Simone D.A., Tsai E.F.P. Neurogenic hyperalgesia psychophysical studies of underlying mechanisms. J Neurophysiol. 66:1991;190-211.
24. LaMotte R.H., Lundberg L.E.R., Torebjörk H.E. Pain, hyperalgesia and activity in nociceptive-C units in humans after intradermal injection of capsaicin. J Physiol (Lond). 448:1992;749-764.
25. Larkin S.W., Williams T.J. Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans. Circ Res. 73:1993;147-154.
26. Lembeck F., Donnerer J. Postocclusive cutaneous vasodilatation mediated by substance P. Naunyn Schmiedebergs Arch Pharmacol. 316:1981;165-171.
27. Lindstrom P., Lindblom U. The analgesic effect of tocainide in trigeminal neuralgia. Pain. 28:1987;45-50.
28. Liu M., Max M.B., Parada S., Rowan J.S., Bennett G.J. The sympathetic nervous system contributes to capsaicin-evoked mechanical allodynia but not pinprick hyperalgesia in humans. J Neurosci. 16:1996;7331-7335.
29. Lynn B., Schutterle S., Pierau F.K. The vasodilator component of neurogenic inflammation is caused by a special subclass of heat-sensitive nociceptors in the skin of the pig. J Physiol (Lond). 494:1996;587-593.
30. Neugebauer V., Schaible H.G., Schmidt R.F. Sensitization of articular afferents to mechanical stimuli by bradykinin. Pflugers Arch. 415:1989;330-335.
31. Novakovic S.D., Tzoumaka E., McGivern J.G., Haraguchi M., Sangameswaran L., Gogas K.R., Eglen R.M., Hunter J.C. Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions. J Neurosci. 18:1998;2174-2187.
32. Rabert D.K., Koch B.D., Ilnicka M., Obernolte R.A., Naylor S.L., Herman R.C., Eglen R.M., Hunter J.C., Sangameswaran L. A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain. 78:1998;107-114.
33. Reeh P.W., Bayer J., Kocher L., Handwerker H.O. Sensitization of nociceptive cutaneous nerve fibers from the rat's tail by noxious mechanical stimulation. Exp Brain Res. 65:1987;505-512.
34. Ringkamp M., Peng Y.B., Campbell J.N., Meyer R.A. Intradermal capsaicin produces a vigorous discharge in mechanically-insensitive A-fiber nociceptors of the monkey. Soc Neurosci Abstr. 23:(part 2):1997;1258.
35. Robinson C.J., Torebjörk H.E., LaMotte R.H. Psychophysical detection and pain ratings of incremental thermal stimuli: a comparison with nociceptor responses in humans. Brain Res. 274:1983;87-106.
36. Rowbotham M.C., Reisner K.L., Fields H.L. Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. Neurology. 41:1991;1024-1028.
37. Sang C.N., Gracely R.H., Max M.B., Bennett G.J. Capsaicin-evoked mechanical allodynia and hyperalgesia cross nerve territories. Evidence for a central mechanism. Anesthesiology. 85:1996;491-496.
38. Schmelz M., Schmidt R., Bickel A., Handwerker H.O., Torebjörk H.E. Differential sensitivity of mechanosensitive and -insensitive C-fibers in human skin to tonic pressure and capsaicin. Soc Neurosci Abstr. 23:((part 1)):1997;1004.
39. Schmelz M., Schmidt R., Weidner C., Torebjörk H.E., Handwerker H.O. Chemical responsiveness of mechanosensitive and -insensitive C nociceptors in human skin. Soc Neurosci Abstr. 24:(part 1):1998;383.
40. Schmidt R., Schmelz M., Forster C., Ringkamp M., Torebjörk H.E., Handwerker H.O. Novel classes of responsive and unresponsive C nociceptors in human skin. J Neurosci. 15:1995;333-341.
41. + currents by lidocaine and bupivacaine reduce firing frequency in DRG neurons. J Neurophysiol. 79:1998;1746-1754.
42. Serra J., Campero M., Ochoa J. Sensitization of silent C nociceptors in areas of secondary hyperalgesia (SH). Neurology. 45:1995;A365.
43. Serra J., Campero M., Ochoa J. Flare and hyperalgesia after intradermal capsaicin injection in human skin. J Neurophysiol. 80:1998;2801-2810.
44. Simone D.A., Baumann T.K., LaMotte R.H. Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin. Pain. 38:1989;99-107.
45. Sorensen J., Bengtsson A., Backman E., Henriksson K.G., Bengtsson M. Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine. Scand J Rheumatol. 24:1995;360-365.
46. Stracke H., Meyer U.E., Schumacher H.E., Federlin K. Mexiletine in the treatment of diabetic neuropathy. Diabetes Care. 15:1992;1550-1555.
47. + channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model. NeuroReport. 9:1998;967-972.
48. Torebjörk H.E., Lundberg L.E., LaMotte R.H. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol (Lond). 448:1992;765-780.
49. + channels in rat sensory neurones by 4030W92, a new antihyperalgesic agent. Br J Pharmacol. 124:1998;953-963.
50. Tsai P.S., Buerkle H., Huang L.T., Lee T.C., Yang L.C., Lee J.H. Lidocaine concentrations in plasma and cerebrospinal fluid after systemic bolus administration in humans. Anesth Analg. 87:1998;601-604.
51. Wallace M.S., Laitin S., Licht D., Yaksh T.L. Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effects on acute sensory thresholds and capsaicin-evoked hyperpathia. Anesthesiology. 86:1997;1262-1272.