Low-dose lidocaine suppresses experimentally induced hyperalgesia in humans

Anesthesiology

Volumn 89, Issue 6, 1998, Pages 1345-1353

  Koppert, Wolfgang ^b   Zeck, Susanne ^b   Sittl, Reinhard ^b   Likar, Rudolf ^b   Knoll, Rainer ^b   Schmelz, Martin ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b NONE

Author keywords

Bier block; Histamine; Itch; Wind up

Indexed keywords

HISTAMINE; LIDOCAINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; IONTOPHORESIS; MALE; MECHANICAL STIMULATION; NOCICEPTION; NORMAL HUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; PRIORITY JOURNAL; PRURITUS; TACTILE STIMULATION; THERMAL STIMULATION;

ADULT; ANESTHETICS, LOCAL; AXONS; BODY TEMPERATURE; DOUBLE-BLIND METHOD; FEMALE; HEAT; HISTAMINE; HUMANS; HYPERALGESIA; INFUSIONS, INTRAVENOUS; IONTOPHORESIS; LIDOCAINE; MALE; MIDDLE AGED; PAIN MEASUREMENT; PAIN THRESHOLD; PHYSICAL STIMULATION; PRESSURE; TOUCH;

EID: 0032421304     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199812000-00011     Document Type: Article

References (39)

1. Ferrante FM, Paggioli J, Cherukuri S, Arthur GR: The analgesicresponse to intravenous lidocaine in the treatment of neuropathicpain. Anesth Analg 1996; 82:91-7
2. Sorensen J, Bengtsson A, Backman E, Henriksson KG, Bengtsson M: Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine. Scand J Rheumatol 1995; 24:360-5
3. Kastrup J, Petersen P, Dejgard A, Angelo HR, Hilsted J: Intravenous lidocaine infusion - a new treatment of chronic painful diabetic neuropathy? Pain 1987; 28:69-75
4. Rowbotham MC, Reisner KL, Fields HL: Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. Neurology 1991; 41:1024-8
5. Lindstrom P, Lindblom U: The analgesic effect of tocainide in trigeminal neuralgia. Pain 1987; 28:45-50
6. Chabal C, Jacobson L, Mariano A, Chancy E, Britell CW: The use of oral mexiletine for the treatment of pain after peripheral nerve injury. ANESTHESIOLOGY 1992; 76:513-7
7. Stracke H, Meyer UE, Schumacher HE, Federlin K: Mexiletine in the treatment of diabetic neuropathy. Diabetes Care 1992; 15:1550-5
8. Galer BS, Miller KV, Rowbotham MC: Response to intravenous lidocaine infusion differs based on clinical diagnosis and site of nervous system injury. Neurology 1993: 43:1233-5
9. Ellemann K, Sjogren P, Banning AM, Jensen TS, Smith T, Geertsen P: Trial of intravenous lidocaine on painful neuropathy in cancer patients. Clin J Pain 1989; 5:291-4
10. Insler SR, O'Connor M, Samonte AF, Bazaral MG: Lidocaine and the inhibition of postoperative pain in coronary artery bypass patients. J Cardiothorac Vase Anesth 1995; 9:541-6
11. Cepeda MS, Delgado M, Ponce M, Cruz CA, Carr DB: Equivalent outcomes during postoperative patient-controlled intravenous analgesia with lidocaine plus morphine versus morphine alone. Anesth Analg 1996; 83:102-6
12. Rowlingson JC, DiFazio CA, Foster J, Carron H: Lidocaine as an analgesic for experimental pain. ANESTHESIOLOGY 1980; 52:20-2
13. Bach FW, Jensen TS, Kastrup J, Stigsby B, Dejgard A: The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy. Pain 1990; 40:29-34
14. Wallace MS, Laitin S, Licht D, Yaksh TL: Concentration-effect relations for intravenous lidocaine infusions in human volunteers: Effects on acute sensory thresholds and capsaicin-evoked hyperpathia. ANESTHESIOLOGY 1997; 86:1262-72
15. Nikolajsen L, Hansen CL, Nielsen J, Keller J, Arendt NL, Jensen TS: The effect of ketamine on phantom pain: A central neuropathicdisorder maintained by peripheral input. Pain 1996; 67:69-77
16. Forster C, Magerl W, Beck A, Geisslinger G, Gall T, Brune K, Handwerker HO: Differential effects of dipyrone, ibuprofen, and paracetamol on experimentally induced pain in man. Agents Actions 1992; 35:112-21
17. Forster C, Anton F, Reeh PW, Weber E, Handwerker HO: Measurement of the analgesic effects of aspirin with a new experimental algesimetric procedure. Pain 1988; 32:215-22
18. Beck PW, Handwerker HO, Zimmermann M: Nervous outflow from the cat's foot during noxious radiant heat stimulation. Brain Res 1974; 67:373-86
19. Adriaensen H, Gybels J, Handwerker HO, Van Hees J: Nociceptor discharges and sensations due to prolonged noxious mechanical stimulation - a paradox. Hum Neurobiol 1984: 3:53-8
20. Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjörk HE: Differential sensitivity of mechanosensitive and -insensitive C-fibers in human skin to tonic pressure and capsaicin (abstract). I. Soc Neurosci Abstr 1997; 23:1004
21. Handwerker HO, Kobal G: Psychophysiology of experimentally induced pain. Physiol Rev 1993; 73:639-71
22. Koltzenburg M, Handwerker HO: Differential ability of human cutaneous nociceptors to signal mechanical pain and to produce vasodilatation. J Neurosci 1994; 14:1756-65
23. Kohlloffel LU, Koltzenburg M, Handwerker HO: A novel technique for the evaluation of mechanical pain and hyperalgesia. Pain 1991; 46:81-7
24. Arendt NL, Petersen FS, Fischer M, Bak P, Bjerring P, Zbinden AM: The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: A placebo-controlled experimental human study. Anesth Analg 1995; 81:63-8
25. Magerl W, Westerman RA, Mohner B, Handwerker HO: Properties of transdermal histamine iontophoresis: Differential effects of season, gender, and body region. J Invest Dermatol 1990; 94:347-52
26. Nischik M, Forster C: Analysis of skin erythema using true color images. IEEE Trans Med Imag 1997; 16:711-6
27. Greiner T, Nischik M, Schmelz M, Forster C, Handwerker HO: Neurogenic flare responses are heterogeneous in superficial and deep layers of human skin. Neurosci Lett 1995: 185:33-6
28. Casale R, Glynn C, Buonocore M: The role of ischaemia in the analgesia which follows Bier's block technique. Pain 1992; 50:169-75
29. Schmidt R, Schmelz M, Ringkamp M, Handwerker HO, Torebjörk HE: Innervation territories of mechanically activated C nociceptor units in human skin. J Neurophysiol 1997; 78:2641-8
30. Kilo S, Forster C, Geisslinger G, Brune K, Handwerker HO: Inflammatory models of cutaneous hyperalgesia are sensitive to effects of ibuprofen in man. Pain 1995; 62:187-93
31. Weidner C, Schmidt R, Hansson B, Handwerker HO, Torebjörk HE, Schmelz M: Different axonal properties of mechanosensitive and mechanoinsensitive C-nociceptors (abstract). Soc Neurosci Abstr 1998; 24:383
32. Ringkamp M, Peng YB, Campbell JN, Meyer RA: Intradermal capsaicin produces a vigorous discharge in mechanically-insensitive A-fiber nociceptors of the monkey. II. Soc Neurosci Abstr 1997; 23:1258
33. LaMotte RH, Lundberg LER, Torebjörk HE: Pain, hyperalgesia and activity in nociceptive-C units in humans after intradermal injection of capsaicin. J Physiol Lond 1992; 448:749-64
34. Fishman SM, Caneris OA, Stojanovic MP, Borsook D: Intravenous lidocaine for treatment-resistant pruritus. Am J Med 1997; 102:584-5
35. Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjörk HE: Specific C-receptors for itch in human skin. J Neurosci 1997; 17:8003-8
36. Bromm B, Scharein E, Darsow U, Ring J: Effects of menthol and cold on histamine-induced itch and skin reactions in man. Neurosci Lett 1995; 187:157-60
37. Heavner JE, Leinonen L, Haasio J, Kytta J, Rosenberg PH: Interaction of lidocaine and hypothermia in Bier blocks in volunteers. Anesth Analg 1989; 69:53-9
38. Sorensen J, Bengtsson A, Backman E, Henriksson KG, Bengtsson M: Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine. Scand J Rheumatol 1995; 24:360-5
39. Wall PD: Do nerve impulses penetrate terminal arborizations? A pre-presynaptic control mechanism. Trends Neurosci 1995; 18:99-103