Voltage- and use-dependent inhibition of Na+ channels in rat sensory neurones by 4030W92, a new antihyperalgesic agent

British Journal of Pharmacology

Volumn 124, Issue 5, 1998, Pages 953-963

  Trezise, D J ^a   John, V H ^a   Xie, X M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

4030W923 NA+ channel; Antihyperalgesic; Dorsal root ganglion; Nociceptors

Indexed keywords

2,4 DIAMINO 5 (2,3 DICHLOROPHENYL) 6 FLUOROMETHYLPYRIMIDINE; ANALGESIC AGENT; CALCIUM ION; SODIUM CHANNEL; SODIUM ION; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; FEMALE; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

EID: 0031809067     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701919     Document Type: Article

References (50)

1. AKOPIAN, A.N., SIVILOTTI, L. & WOOD, J.N. (1996). A tetrodotoxin-resistant sodium channel expressed by sensory neurones. Nature, 379, 257-262.
2. BACK, F.W., JENSEN, T.S., KASTRUP, J., STIGSBY, B. & DEJGARD, A. (1990). The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy. Pain, 40, 29-34.
3. BLACK, J.A., DIB-HAJJ, S., MCNABOLA, K., JESTE, S., RIZZO, M.A., KOCSIS, J.D. & WAXMAN, S.G. (1996). Spinal sensory neurones express multiple sodium channel α-subunit mRNAs. Mol. Brain Res., 43, 117-131.
4. BLACK, J.A. & WAXMAN, S.G. (1996). Sodium channel expression: a dynamic process in neurones and non-neuronal cells. Dev. Neurosci., 18, 139-152.
5. BOAS, R.A., COVINO, B.G. & SHAHNARIAN, A. (1982). Analgesic responses to i.v. lignocaine. Br. J. Anaesthesiol., 54, 501-505.
6. BOSSU, J.-L. & FELTZ, A. (1984). Patch-clamp study of the tetrodotoxin-resistant sodium current in group C sensory neurones. Neurosci. Lett., 51, 241-246.
7. CAFFREY, J.M., ENG, D.L., BLACK, J.A., WAXMAN, S.G. & KOCSIS, J.D. (1992). Three types of sodium channels in adult dorsal root ganglion neurones. Brain Res., 592, 283-297.
8. 4 receptors couple positively to tetrodotoxin-insensitive sodium channels in a subpopulation of capsaicin-sensitive rat sensory neurones. J. Neurosci., 17, 7181-7189.
9. CARDENAS, C.G., DEL MAR, L.P. & SCROGGS, R.S. (1995). Variation in serotinergic inhibition of calcium currents in four types of rat sensory neurones differentiated by membrane properties. J. Neurophysiol., 74, 1870-1879.
10. CATTERAL, W.A. (1992). Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev., 72, S15-S48.
11. CHABAL, C., JACOBSEN, L., MARIANO, A., CHANEY, E. & BRITELL, C.W. (1992). The use of oral mexilitine for the treatment of pain after peripheral nerve injury. Anaesthesiology, 76, 513-516.
12. CLAYTON, N.M., COLLINS, S.D., SARGENT, R., BROWN, T., NOBBS, M. & BOUNTRA, C. (1998). The effect of the novel sodium channel blocker 4030W92 in models of acute and chronic inflammatory pain in the rat. Br. J. Pharmacol., Proc. Suppl., (in press).
13. COLLINS, S.D., CLAYTON, N.M., NOBBS, M. & BOUNTRA, C. (1998). The effect of 4030W92, a novel sodium channel blocker, on the treatment of neuropathic pain in the rat. Br. J. Pharmacol., Proc. Suppl. (in press).
14. CUMMINS, T.R. & WAXMAN, S.G. (1997). Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurones after nerve injury. J. Neurosci., 17, 3503-3514.
15. DEJGARD, A., PETERSON, P. & KASTRUP, J. (1988). Mexilitine for treatment of chronic painful diabetic neuropathy. Lancet, 29, 9-11.
16. + channel immunolocalisation in peripheral mammalian axons and changes following nerve injury and neuroma formation. J. Neurosci., 13, 1976-1992.
17. DIB-HAJJ, S., BLACK, J.A., FELTS, P. & WAXMAN, S.G. (1996). Down regulation of transcripts for Na channel subunit α-SNS in spinal sensory neurones following axotomy. Proc. Natl. Acad. Sci. U.S.A., 93, 14950-14954.
18. ELLIOTT, A.A. & ELLIOTT, J.R. (1993). Characterisation of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J. Physiol., 463, 39-56.
19. 2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J. Physiol., 495, 429-440.
20. 2+ channels. Trends Pharmacol. Sci., 18, 37-42.
21. FOX, A.P., NOWYCKY, M.C. & TSIEN, R.W. (1987). Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J. Physiol., 394, 149-172.
22. GOLD, M.S., DASTMALCHI, S. & LEVINE, J.D. (1996a). Co-expression of nociceptor properties in dorsal root ganglion neurones from the adult rat in vitro. Neuroscience, 71, 265-275.
23. + current in nociceptors. Proc. Natl. Acad. Sci. U.S.A., 93, 1108-1112.
24. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch., 391, 85-100.
25. + channel α subunit by the neuroprotective drug riluzole. Mol. Pharmacol., 45, 1055-1060.
26. HILLE, B. (1993). Mechanisms of block. In: Ionic channels of excitable membranes. ed Hille, B. Ch. 15 pp. 390-422. Massachusetts: Sinauer Associates Inc.
27. HODGKIN, A.L. & HUXLEY, A.F. (1952a). Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo. J. Physiol., 116, 449-472.
28. HODGKIN, A.L. & HUXLEY, A.F. (1952b). The components of membrane conductance in the giant axon of Loligo. J. Physiol., 116, 473-496.
29. KUO, C.-G. & BEAN, B.P. (1994). Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurones. Mol. Pharmacol., 46, 716-725.
30. MARCHETTINI, P., LACARENZA, M., MARANGONI, C., PELLEGATA, G., SOTGIU, M.L. & MIRNE, S. (1992). Lidocaine test in neuralgia. Pain, 48, 377-382.
31. + channels. J. Neurophysiol., 72, 349-359.
32. MINTZ, I.M., ADAMS, M.E. & BEAN, B.P. (1992). P-type calcium channels in rat central and peripheral neurones. Neuron. 9, 85-95.
33. 2 and in the chronic hyperalgesia in rats with streptozotocin-induced diabetes. Pain, 63, 33-37.
34. 2+ current in newborn rat dorsal root ganglia. Pflügers Arch., 420, 590-594.
35. PLUMMER, M.R., LOTOTHETIS, D.E. & HESS, P. (1989). Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurones. Neuron, 2, 1453-1463.
36. + channels, expressed in a mammalian cell line, by local anaesthetic, anti-arrhythmic and anticonvulsant drugs. Mol. Pharmacol., 40, 756-765.
37. 2+ channels in rat central and peripheral neurones: high threshold current resistant to dihydropyridine blockers and ω-conotoxin. Neuron, 6, 269-280.
38. + currents in cutaneous afferent dorsal root ganglion neurones following axotomy. Neurobiol. Dis., 2, 87-96.
39. ROY, M.L. & NARAHASHI, T. (1992). Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistanl sodium channels in rat dorsal root ganglion neurones. J. Neurosci., 12, 2104-2111.
40. RUSH, A.M. & ELLIOTT, J.R. (1997). Phenytoin and carbamazepine: differential inhibition of sodium currents in small cells from adult rat dorsal root ganglia. Neurosci. Lett., 226, 905-998.
41. SANGAMESWARAN, L., DELGADO, S.G., FISH, L.M., KOCH, B.D., JAKEMAN, L.B., STEWART, G.R., SZE, P., HUNTER, J.C., EGLEN, R.M. & HERMAN, R.C. (1996). Structure and function of a noval voltage-gated tetrodotoxin-resistant sodium channel specific to sensory neurones. J. Biol. Chem., 271, 5953-5956.
42. + channels. J. Pharmacol. Exp. Ther., 282, 707-714.
43. SONG, J.-H., NAGATA, K., HUANG, C.-S., YEH, J.Z. & NARAHASHI, T. (1996). Differential block of two types of sodium channels by anticonvulsants. Neuro Report, 7, 3031-3036.
44. + currents by mexiletine at the single channel level in guinea-pig ventricular myocytes. Br. J. Pharmacol., 110, 183-192.
45. + channel blockers: lidocaine, carbamazepine and mexilitine. Anaesthesiology, 74, 949-951.
46. + channels in rat sensory neurones by the novel antihypersensitivity agent. 4030W92. Br. J. Pharmacol. Proc. Suppl. (in press).
47. WAXMAN, S.G., KOCSIS, J.D. & BLACK, J.A. (1994). Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurones, and is re-expressed following axotomy. J. Neurophysiol., 72, 466-470.
48. + channels. Neuroscience, 73, 951-962.
49. + channels in rat hippocampal neurones. Pflügers Arch., 430, 437-446.
50. ZAKRZEWSKA, J.M., CHAUDRY, Z., NURMIKKO, T.J., PATTON, D.W. & MULLENS, E.L. (1997). Lamotrigine (Lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. Pain, 73, 223-230.