TATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo

Molecular and Cellular Biology

Volumn 20, Issue 5, 2000, Pages 1478-1488

  Geisberg, Joseph V ^a   Struhl, Kevin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED RNA POLYMERASE III; MUTANT PROTEIN; TATA BINDING PROTEIN;

ARTICLE; CELL GROWTH; CELL VIABILITY; ENHANCER REGION; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN INTERACTION; REPRESSOR GENE; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); MUTATION; PROMOTER REGIONS (GENETICS); TATA BOX; TATA-BOX BINDING PROTEIN; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0033961273     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.5.1478-1488.2000     Document Type: Article

References (63)

1. Arndt, K. M., S. Ricupero-Hovasse, and F. Winston. 1995. TBP mutants defective in activated transcription in vivo. EMBO J. 14:1490-1497.
2. Auble, D. T., K. E. Hansen, C. G. F. Mueller, W. S. Lane, J. Thorner, and S. Hahn. 1994. Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism. Genes Dev. 8:1920-1934.
3. Blair, W. S., and B. R. Cullen. 1997. A yeast TATA-binding protein mutant that selectively enhances gene expression from weak RNA polymerase II promoters. Mol. Cell. Biol. 17:2888-2896.
4. Bryant, G. O., L. S. Martel, S. K. Burley, and A. J. Berk. 1996. Radical mutations reveal TATA-box binding protein surfaces required for activated transcription in vivo. Genes Dev. 10:2491-2504.
5. Burley, S. K., and R. G. Roeder. 1996. Biochemistry and structural biology of transcription factor IID (TFIID). Annu. Rev. Biochem. 65:769-799.
6. Chatterjee, S., and K. Struhl. 1995. Connecting a promoter-bound protein to the TATA-binding protein overrides the need for a transcriptional activation region. Nature 374:820-822.
7. Chen, W., and K. Struhl. 1988. Saturation mutagenesis of a yeast his3 TATA element: genetic evidence for a specific TATA-binding protein. Proc. Natl. Acad. Sci. USA 85:2691-2695.
8. Coleman, R. A., and B. F. Pugh. 1997. Slow dimer dissociation of the TATA binding protein dictates the kinetics of DNA binding. Proc. Natl. Acad. Sci. USA 94:7221-7226.
9. Collart, M. A., and K. Struhl. 1994. NOT1(CDC36), NOT2(CDC36), NOT3, and NOT4 encode a global negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev. 8:525-537.
10. Cooper, J. P., S. Y. Roth, and R. T. Simpson. 1994. The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev. 8:1400-1410.
11. Cormack, B. P., M. Strubin, A. S. Ponticelli, and K. Struhl. 1991. Functional differences between yeast and human TFIID are localized to the highly conserved region. Cell 65:341-348.
12. Cormack, B. P., and K. Struhl. 1992. The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells. Cell 69:685-696.
13. Cormack, B. P., and K. Struhl. 1993. Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription. Science 262:244-248.
14. Cosma, M. P., T. Tanaka, and K. Nasmyth. 1999. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle-and developmentally regulated promoter. Cell 97:299-311.
15. Field, J., J.-I. Nikawa, D. Broek, B. MacDonald, L. Rodgers, I. A. Wilson, R. A. Lerner, and M. Wigler. 1988. Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol. Cell. Biol. 8:2159-2165.
16. Gadbois, E. L., D. M. Chao, J. C. Reese, M. R. Green and R. A. Young. 1997. Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Proc. Natl. Acad. Sci. USA 94:3145-3150.
17. Gaudreau, L., M. Adam and M. Ptashne. 1998. Activation of transcription in vitro by recruitment of the yeast RNA polymerase II holoenzyme. Mol. Cell 1:913-916.
18. Herschbach, B. M., M. B. Arnaud, and A. D. Johnson. 1994. Transcriptional repression directed by the yeast a2 protein in vitro. Nature 370:309-311.
19. Huang, L., W. Zhang, and S. Y. Roth. 1997. Amino termini of histones H3 and H4 are required for a1-a2 repression in yeast. Mol. Cell. Biol. 17:6555-6562.
20. Imbalzano, A. N., H. Kwon, M. R. Green, and R. E. Kingston. 1994. Facilitated binding of TATA-binding protein to nucleosomal DNA. Nature 370: 481-485.
21. C TATA elements. Mol. Cell. Biol. 15:7059-7066.
22. Iyer, V. and K. Struhl. 1996. Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 93: 5208-5212.
23. Jackson-Fisher, A. J., C. Chitikila, M. Mitra, and B. F. Pugh. 1999. A role for TBP dimerization in preventing unregulated gene expression. Mol. Cell 3:717-727.
24. Kadosh, D., and K. Struhl. 1997. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89:365-371.
25. Kadosh, D., and K. Struhl. 1998. Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Genes Dev. 12:797-805.
26. Kadosh, D., and K. Struhl. 1998. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol. Cell. Biol. 18:5121-5127.
27. Keaveney, M., and K. Struhl. 1998. Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeast. Mol. Cell 1:917-924.
28. Keleher, C. A., M. J. Redd, J. Schultz, M. Carlson, and A. D. Johnson. 1992. Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68:709-719.
29. Kim, J. L., D. B. Nikolov and S. K. Burley. 1993. Co-crystal structure of TBP recognizing the minor groove of a TATA element. Nature 365:520-527.
30. Kim, S., J. G. Na, M. Hampsey, and D. Reinberg. 1997. The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Proc. Natl. Acad. Sci. USA 94:820-825.
31. Kim, Y., J. H. Geiger, S. Hahn, and P. B. Sigler. 1993. Crystal structure of a yeast TBP-TATA box complex. Nature 365:512-520.
32. Kim, Y.-J., S. Bjorklund, Y. Li, M. H. Sayre, and R. D. Kornberg. 1994. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77:599-608.
33. Klages, N., and M. Strubin. 1995. Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo. Nature 374:822-823.
34. Klein, C., and K. Struhl. 1994. Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo. Science 266:280-282.
35. Kokubo, T., M. J. Swanson, J. I. Nishikawa, A. G. Hinnebusch, and Y. Nakatani. 1998. The yeast TAF145 inhibitory domain and TFIIA competitively bind to TATA-binding protein. Mol. Cell. Biol. 18:1003-1012.
36. Koleske, A. J., and R. A. Young. 1994. An RNA polymerase II holoenzyme responsive to activators. Nature 368:466-469.
37. Krebs, J. E., M.-H. Kuo, C. D. Allis and C. L. Peterson. 1999. Cell cycle-regulated histone acetylation required for expression of the yeast HO gene. Genes Dev. 13:1412-1421.
38. Kuchin, S., P. Yeghiayan, and M. Carlson. 1995. Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast. Proc. Natl. Acad. Sci. USA 92:4006-4010.
39. Kuo, M.-H., J. Zhou, P. Jambeck, M. E. A. Churchill, and C. D. Allis. 1998. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. Genes Dev. 12:627-639.
40. Kuras, L., and K. Struhl. 1999. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature 389:609-612.
41. Lee, M., and K. Struhl. 1995. Mutations on the DNA-binding surface of TBP can specifically impair the response to acidic activators in vivo. Mol. Cell. Biol. 15:5461-5469.
42. Lee, M., and K. Struhl. 1997. A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo. Mol. Cell. Biol. 17:1336-1345.
43. Lee, T. I., J. J. Wyrick, S. S. Koh, E. G. Jennings, E. L. Gadbois, and R. A. Young. 1998. Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme. Mol. Cell. Biol. 18:4455-4462.
44. Li, X.-L., A. Virbasius, X. Zhu, and M. R. Green. 1999. Enhancement of TBP binding by activators and general transcription factors. Nature 389:605-609.
45. Moqtaderi, Z., M. Keaveney, and K. Struhl. 1998. The histone H3-like TAF is broadly required for transcription in yeast. Mol. Cell 2:675-682.
46. Nikolov, D. B., S.-H. Hu, J. Lin, A. Gasch, A. Hoffman, M. Horikoshi, N.-H. Chua, R. G. Roeder, and S. K. Burley. 1992. Crystal structure of TFIID TATA-box binding protein. Nature 360:40-46.
47. Orphanides, G., T. Lagrange, and D. Reinberg. 1996. The general initiation factors of RNA polymerase II. Genes Dev. 10:2657-2683.
48. Perez-Howard, G. M., P. A. Weil, and J. M. Beechem. 1995. Yeast TATA binding protein interaction with DNA: fluorescence determination of oligomeric state, equilibrium binding, on-rate, and dissociation kinetics. Biochemistry 34:8005-8017.
49. Ptashne, M., and A. Gann. 1997. Transcriptional activation by recruitment. Nature 386:569-577.
50. Ranish, J. A., N. Yudkovsky, and S. Hahn. 1999. Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB. Genes Dev. 13:49-63.
51. Roeder, R. G. 1996. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem. Sci. 21:327-335.
52. Rundlett, S. E., A. A. Carmen, N. Suka, B. M. Turner and M. Grunstein. 1998. Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature 392:831-835.
53. Stargell, L. A., and K. Struhl. 1995. The TBP-TFIIA interaction in the response to acidic activators in vivo. Science 269:75-78.
54. Stargell, L. A., and K. Struhl. 1996. A new class of activation-defective TATA-binding protein mutants: evidence for two steps of transcriptional activation in vivo. Mol. Cell. Biol. 16:4456-4464.
55. Strubin, M., and K. Struhl. 1992. Yeast TFIID with altered DNA-binding specificity for TATA elements. Cell 68:721-730.
56. Struhl, K. 1995. Yeast transcriptional regulatory mechanisms. Annu. Rev. Genet. 29:651-674.
57. Struhl, K. 1996. Chromatin structure and RNA polymerase II connection: implications for transcription. Cell 84:179-182.
58. Struhl, K. 1999. Fundamentally different logic of gene expression in eukaryotes and prokaryotes. Cell 98:1-4.
59. Taggart, A. K. P., and B. F. Pugh. 1996. Dimerization of TFIID when not bound to DNA. Science 272:1331-1333.
60. Tzamarias, D., and K. Struhl. 1994. Functional dissection of the yeast Cyc8-Tup1 transcriptional corepressor complex. Nature 369:758-761.
61. Wahi, M., and A. D. Johnson. 1995. Identification of genes required for a2 repression in Saccharomyces cerevisiae. Genetics 140:79-90.
62. Xiao, H., J. D. Friesen, and J. T. Lis. 1995. Recruiting TATA-binding protein to a promoter: transcriptional activation without an upstream activator. Mol. Cell. Biol. 15:5757-5761.
63. Yean, D., and J. Gralla. 1997. Transcription reinitiation rate: a special role for the TATA box. Mol. Cell. Biol. 17:3809-3816.