Neutrophils play a protective nonphagocytic role in systemic Mycobacterium tuberculosis infection of mice

Infection and Immunity

Volumn 68, Issue 2, 2000, Pages 577-583

  Pedrosa, Jorge ^a   Saunders, Bernadette M ^b   Appelberg, Rui ^a   Orme, Ian M ^b   Silva, Manuel T ^a   Cooper, Andrea M ^b  

^a UNIVERSITY OF PORTO   (Portugal)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MONOCLONAL ANTIBODY; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL IMMUNITY; BACTERIAL OVERGROWTH; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; IMMUNOMODULATION; INFECTION RESISTANCE; INOCULATION; LEUKOCYTE ACTIVATION; LYMPHOID TISSUE; MACROPHAGE; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PERITONEAL FLUID; PHAGOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; FEMALE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; NEUTROPHILS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; TUBERCULOSIS;

EID: 0033958803     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.2.577-583.2000     Document Type: Article

References (53)

1. Appelberg, R. 1992. Interferon-gamma (IFN-γ) and macrophage inflammatory proteins (MIP)-1 and -2 are involved in the regulation of the T cell-dependent chronic peritoneal neutrophilia of mice infected with mycobacteria. Clin. Exp. Immunol. 89:269-273.
2. Appelberg, R. 1992. T cell regulation of the chronic peritoneal neutrophilia during mycobacterial infections. Clin. Exp. Immunol. 89:120-125.
3. Appelberg, R., A. G. Castro, S. Gomes, J. Pedrosa, and M. T. Silva. 1995. Susceptibility of beige mice to Mycobacterium avium: role of neutrophils. Infect. Immun. 63:3381-3387.
4. Appelberg, R., A. G. Castro, and M. T. Silva. 1994. Neutrophils as effector cells of T-cell-mediated, acquired immunity in murine listeriosis. Immunology 83:302-307.
5. Appelberg, R., J. M. Pedrosa, and M. T. Silva. 1991. Host and bacterial factors control the Mycobacterium avium-induced chronic peritoneal granulocytosis in mice. Clin. Exp. Immunol. 83:231-236.
6. Barteneva, N., I. Theodor, E. M. Peterson, and L. M. de la Maza. 1996. Role of neutrophils in controlling early stages of a Chlamydia trachomatis infection. Infect. Immun. 64:4830-4833.
7. Bendelac, A., M. N. Rivera, S. H. Park, and J. H. Roark. 1997. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15:535-562.
8. Bliss, S. K., A. J. Marshall, Y. Zhang, and E. Y. Denkers. 1999. Human polymorphonuclear leukocytes produce IL-12, TNF-alpha, and the chemokines macrophage-inflammatory protein-1 alpha and -1 beta in response to Toxoplasma gondii antigens. J. Immunol. 162:7369-7375.
9. Bliss, S. K., Y. Zhang, and E. Y. Denkers. 1999. Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-γ-independent IL-12. J. Immunol. 163:2081-2088.
10. Brown, A. E. 1987. Capacity of human neutrophils to kill Mycobacterium tuberculosis. J. Infect. Dis. 156:985-989.
11. Cassatella, M. A. 1996. Cytokine production by neutrophils in vivo, p. 163-180. In M. A. Cassatella (ed.), Cytokine produced by polymorphonuclear neutrophils: molecular and biological aspects. R. G. Landes Company, Austin, Tex.
12. Cassatella, M. A. 1995. The production of cytokines by polymorphonuclear neutrophils. Immunol. Today 16:21-26.
13. Cassatella, M. A., L. Meda, S. Gasparini, A. D'Andrea, X. Ma, and G. Trinchieri. 1996. Interleukin-12 production by human polymorphonuclear leukocytes. Eur. J. Immunol. 25:1-5.
14. Castro, A. G., R. A. Silva, and R. Appelberg. 1995. Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice. J. Immunol. 155:2013-2019.
15. Conlan, J. W. 1997. Critical roles of neutrophils in host defense against experimental systemic infections of mice by Listeria monocytogenes, Salmonella typhimurium, and Yersinia enterocolitico. Infect. Immun. 65:630-635.
16. Conlan, J. W., and R. J. North. 1994. Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody. J. Exp. Med. 179:259-268.
17. Cooper, A. M., J. E. Callahan, M. Keen, J. T. Belisle, and I. M. Orme. 1997. Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis. Tuber. Lung Dis. 78:67-73.
18. Cooper, A. M., D. K. Dalton, T. A. Stewart, J. P. Griffin, D. G. Russell, and I. M. Orme. 1993. Disseminated tuberculosis in Interferon gamma gene-disrupted mice. J. Exp. Med. 178:2243-2247.
19. Cooper, A. M., J. Magram, J. Ferrante, and I. M. Orme. 1997. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J. Exp. Med. 186:39-45.
20. Cooper, A. M., A. D. Roberts, E. R. Rhoades, J. E. Calahan, D. M. Getzy, and I. M. Orme. 1995. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology 84:423-432.
21. Czuprynski, C. J., J. F. Brown, N. Maroushek, R. D. Wagner, and H. Steinberg. 1994. Administration of anti-granulocyte mAb RB6-8C5 impairs the resistance of mice to Listeria monocytogenes infection. J. Immunol. 156:1836-1846.
22. Czuprynski, C. J., J. F. Brown, R. D. Wagner, and H. Steinberg. 1994. Administration of antigranulocyte monoclonal antibody RB6-8C5 prevents expression of acquired resistance to Listeria monocytogenes infection in previously immunized mice. Infect. Immun. 62:5161-5163.
23. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte Interferon gamma-production by suppressing natural killer cell stimulatory factor/ IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041-1048.
24. Denis, M. 1991. Human neutrophils, activated with cytokines or not, do not kill virulent Mycobacterium tuberculosis. J. Infect. Dis. 163:919-920.
25. Doherty, D. E., G. P. Downey, G. S. Worthen, C. Haslett, and P. M. Henson. 1988. Monocyte retention and migration in pulmonary inflammation. Requirement for neutrophils. Lab. Invest. 59:200-213.
26. El-Hag, A., and R. A. Clark. 1987. Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system. J. Immunol. 139: 2406-2413.
27. Flynn, J. L., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249-2254.
28. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115-6119.
29. Heifets, L., K. Imai, and M. B. Goren. 1980. Expression of peroxidase-dependent iodonation by macrophages ingesting neutrophil debris. J. Reticuloendothel. Soc. 28:391-404.
30. Jensen, J., T. Warner, and E. Balish. 1994. The role of phagocytic cells in resistance to disseminated candidiasis in granulocytopenic mice. J. Infect. Dis. 170:900-905.
31. Jones, G. S., H. J. Amirault, and B. R. Andersen. 1990. Killing of Mycobacterium tuberculosis by neutrophils: a nonoxidative process. J. Infect. Dis. 162:700-704.
32. Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heufler, E. Kampgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741-746.
33. Leung, K. P., and M. B. Goren. 1989. Uptake and utilization of human polymorphonuclear leucocyte granule myeloperoxidase. Cell Tissue Res. 257:653-656.
34. Lima, M. F., and F. Kierszenbaum. 1985. Lactoferrin effects on phagocytic cells function. I. Increased uptake and killing of an intracellular parasite by murine macrophages and human monocytes. J. Immunol. 134:4176-4183.
35. Lincoln, J. A., D. L. Lefkowitz, A. Castro, S. S. Lefkowitz, N. Moguilevsky, and A. Bollen. 1995. Exogenous myeloperoxidase enhances bacterial phagocytosis and intracellular killing by macrophages. Infect. Immun. 63:3042-3047.
36. Marchant, A., C. Bruyns, P. Vandenabeele, M. Ducarme, C. Gerard, A. Delvaux, D. De Groote, D. Abramowicz, T. Velu, and M. Goldman. 1994. Interleukin-10 controls interferon-gamma and tumor necrosis factor production during experimental endotoxemia. Eur. J. Immunol. 24:1167-1171.
37. Pereira, H. A., W. M. Shafer, J. Pohl, L. E. Martin, and J. K. Spitznagel. 1990. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. J. Clin. Invest. 85:1468-1476.
38. Petrofsky, M., and L. E. Bermudez. 1999. Neutrophils from Mycobacterium avium-infected mice produce TNF-α, IL-12, and IL-1ß and have a putative role in early host response. Clin. Immunol. 91:354-358.
39. Riedel, D. D., and S. H. Kaufmann. 1997. Chemokine secretion by human polymorphonuclear granulocytes after stimulation with Mycobacterium tuberculosis and lipoarabinomannan. Infect. Immun. 65:4620-4623.
40. Rogers, H. W., and E. R. Unanue. 1993. Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice. Infect. Immun. 61:5090-5096.
41. + T helper subset selection in mice with candidiasis. J. Immunol. 158:2356-2362.
42. Romani, L., A. Mencacci, E. Cenci, R. Spaccapelo, G. Del Sero, I. Nicoletti, G. Trinchieri, F. Bistoni, and P. Puccetti. 1997. Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice. J. Immunol. 158:5349-5356.
43. Saunders, B. M., and C. Cheers. 1996. Intranasal infection of beige mice with Mycobacterium avium complex: role of neutrophils and natural killer cells. Infect. Immun. 64:4236-4241.
44. Saunders, B. M., Y. Zhan, and C. Cheers. 1995. Endogenous interleukin-12 is involved in resistance of mice to Mycobacterium avium complex infection. Infect. Immun. 63:4011-4015.
45. Sayles, P. C., and L. L. Johnson. 1996. Exacerbation of toxoplasmosis in neutrophil-depleted mice. Nat. Immun. 15:249-258.
46. Schoenhaut, D. S., A. O. Chua, A. G. Wolitzsky, P. M. Quinn, C. M. Dwyer, W. McComas, P. C. Familletti, M. K. Gately, and U. Gubler. 1992. Cloning and expression of murine IL-12. J. Immunol. 148:3433-3440.
47. Silva, M. T., M. N. T. Silva, and R. Appelberg. 1989. Neutrophil-macrophage cooperation in the host defence against mycobacterial infections. Microb. Pathog. 6:369-380.
48. Silva, R. A., T. Pais, and R. Appelberg. 1998. Evaluation of IL-12 in immunotherapy and vaccine design in experimental Mycobacterium avium infections. J. Immunol. 161:5578-5585.
49. Sjostedt, A., J. W. Conlan, and R. J. North. 1994. Neutrophils are critical for host defense against primary infection with the facultative intracellular bacterium Francisella tularensis in mice and participate in defense against reinfection. Infect. Immun. 62:2779-2783.
50. Territo, M. C., T. Ganz, M. E. Selsted, and R. Lehrer. 1989. Monocyte-chemotactic activity of defensins from human neutrophils. J. Clin. Invest. 84:2017-2020.
51. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
52. Trinchieri, G., and F. Gerosa. 1996. Immunoregulation by interleukin-12. J. Leukoc. Biol. 59:505-511.
53. Wynn, T. A., I. Eltoum, A. W. Cheever, F. A. Lewis, W. C. Gause, and A. Sher. 1993. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunol. 151:1430-1440.