Chronic blockade of NO synthase activity induces a proinflammatory phenotype in the arterial wall: Prevention by angiotensin II antagonism

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 9, 1998, Pages 1408-1416

  Luvarà, Giuseppina ^a   Pueyo, Maria E ^a   Philippe, Monique ^a   Mandet, Chantal ^b   Savoie, Françoise ^a   Henrion, Daniel ^c   Michel, Jean Baptiste ^a  

^a INSERM   (France)

^b HÔPITAL BROUSSAIS   (France)

^c HÔPITAL LARIBOISIÈRE   (France)

Author keywords

AT1 receptor; Cell adhesion molecules; Inducible NO synthase; L NAME hypertension; Macrophages

Indexed keywords

ANGIOTENSIN; IRBESARTAN; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY WALL; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER;

EID: 0031718914     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.9.1408     Document Type: Article

References (11)

1. Arnal JF, Warin L, Michel JB. Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. J Clin Invest. 1992;90:647-652.
2. Ribeiro MO, Antunes E, de Nucci G, Lovisolo SM, Zatz R. Chronic inhibition of nitric oxide synthesis: a new model of arterial hypertension. Hypertension. 1992;20:298-303.
3. Baylis C, Mitruka B, Deng A. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. J Clin Invest. 1992;90:278-281.
4. Xu Y, Arnal JF, Hinglais N, Appay MD, Laboulandine I, Bariety J, Michel JB. Renal hypertensive angiopathy: comparison between chronic NO suppression and DOCA-salt intoxication. Am J Hypertens. 1995;8:167-176.
5. Blot S, Arnal JF, Xu Y, Gray F, Michel JB. Spinal cord infarcts during long-term inhibition of nitric oxide synthase in rats. Stroke. 1994;25:1666-1673.
6. Arnal JF, El Amrani AI, Chatellier G, Menard J, Michel JB. Cardiac weight in hypertension induced by nitric oxide synthase blockade. Hypertension. 1993;22:380-387.
7. G-nitro-L-arginine methyl ester due to converting enzyme inhibition. J Cardiovasc Pharmacol. 1996;28:142-148.
8. Kung CF, Moreau P, Takase H, Luscher TF. L-NAME hypertension alters endothelial and smooth muscle function in rat aorta: prevention by trandolapril and verapamil. Hypertension. 1995;26:744-751.
9. Takemoto M, Egashira K, Usui M, Numaguchi K, Tomita H, Tsutsui H, Shimokawa H, Sueishi K, Takeshita A. Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats. J Clin Invest. 1997;99:278-287.
10. Pollock DM, Polakowski JS, Divish BJ, Opgenorth TJ. Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition. Hypertension. 1993;21:660-666.
11. G-nitro L-arginine methyl ester. Hypertension. 1996:28:361-366.