-
1
-
-
0029036377
-
The catalytic mechanism and structure of thymidylate synthase
-
Carreras C. W., Santi D. V. The catalytic mechanism and structure of thymidylate synthase. Annu. Rev. Biochem. 64:1995;721-762.
-
(1995)
Annu. Rev. Biochem.
, vol.64
, pp. 721-762
-
-
Carreras, C.W.1
Santi, D.V.2
-
2
-
-
0027403420
-
The design of thymidylate synthase inhibitors using protein crystal structure: The synthesis and biological evaluation of a novel class of 5-substituted quinazolines
-
Webber S. E., Blackman T. M., Attard J., Deal J. G., Kathardekar V., Welsh K. M., Webber S., Janson C. A., Matthews D. A., Smith W. W., Freer S. T., Jordan S. R., Bacquet R. J., Howland E. F., Booth C. L. J., Ward R. W., Hermann M., White J., Morse C. A., Hilliard J. A., Bartlett C. A. The design of thymidylate synthase inhibitors using protein crystal structure: The synthesis and biological evaluation of a novel class of 5-substituted quinazolines. J. Med. Chem. 36:1993;733-746.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 733-746
-
-
Webber, S.E.1
Blackman, T.M.2
Attard, J.3
Deal, J.G.4
Kathardekar, V.5
Welsh, K.M.6
Webber, S.7
Janson, C.A.8
Matthews, D.A.9
Smith, W.W.10
Freer, S.T.11
Jordan, S.R.12
Bacquet, R.J.13
Howland, E.F.14
Booth, C.L.J.15
Ward, R.W.16
Hermann, M.17
White, J.18
Morse, C.A.19
Hilliard, J.A.20
Bartlett, C.A.21
more..
-
3
-
-
0030991713
-
Use of strain in a stereospecific catalytic mechanism: Crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate
-
Hyatt D. C., Maley F., Montfort W. R. Use of strain in a stereospecific catalytic mechanism: Crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate. Biochemistry. 36:1997;4585-4594.
-
(1997)
Biochemistry
, vol.36
, pp. 4585-4594
-
-
Hyatt, D.C.1
Maley, F.2
Montfort, W.R.3
-
5
-
-
0033547816
-
Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2′-deoxyuridine 5-monophosphate
-
Liu Y., Barrett J. E., Schultz P. G., Santi D. V. Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2′-deoxyuridine 5-monophosphate. Biochemistry. 38:1999;848-852.
-
(1999)
Biochemistry
, vol.38
, pp. 848-852
-
-
Liu, Y.1
Barrett, J.E.2
Schultz, P.G.3
Santi, D.V.4
-
6
-
-
0028961319
-
Complete restoration of activity to inactive mutants of Escherichia coli thymidylate synthase: Evidence that E. coli thymidylate synthase is a half-the-sites of activity enzyme
-
Maley F., Pedersen-Lane J., Changchien L-M. Complete restoration of activity to inactive mutants of Escherichia coli thymidylate synthase: Evidence that E. coli thymidylate synthase is a half-the-sites of activity enzyme. Biochemistry. 34:1995;1469-1474.
-
(1995)
Biochemistry
, vol.34
, pp. 1469-1474
-
-
Maley, F.1
Pedersen-Lane, J.2
Changchien, L.-M.3
-
7
-
-
0028908401
-
Isolation and expression of rat thymidylate synthase cDNA: Phylogenetic comparison with human and mouse thymidylate synthases
-
Ciesla J., Weiner K. X. B., Weiner R. S., Reston J. T., Maley G. F., Maley F. Isolation and expression of rat thymidylate synthase cDNA: Phylogenetic comparison with human and mouse thymidylate synthases. Biochim. Biophys. Acta. 1261:1995;233-242.
-
(1995)
Biochim. Biophys. Acta
, vol.1261
, pp. 233-242
-
-
Ciesla, J.1
Weiner, K.X.B.2
Weiner, R.S.3
Reston, J.T.4
Maley, G.F.5
Maley, F.6
-
9
-
-
0020805705
-
Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product
-
Belfort M., Maley G. F., Pedersen-Lane J., Maley F. Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product. Proc. Nat. Acad. Sci. USA. 80:1983;4914-4918.
-
(1983)
Proc. Nat. Acad. Sci. USA
, vol.80
, pp. 4914-4918
-
-
Belfort, M.1
Maley, G.F.2
Pedersen-Lane, J.3
Maley, F.4
-
10
-
-
0033019832
-
Crystal structure of thymidylate synthase A from Bacillus subtilis
-
Fox K. M., Maley F., Garibian A., Changchien L-M., Van Roey P. Crystal structure of thymidylate synthase A from Bacillus subtilis. Protein Sci. 8:1999;538-544.
-
(1999)
Protein Sci.
, vol.8
, pp. 538-544
-
-
Fox, K.M.1
Maley, F.2
Garibian, A.3
Changchien, L.-M.4
Van Roey, P.5
-
11
-
-
0002242695
-
Direct spectrophotometric evidence for the oxidation of tetrahydrofolate during the enzymatic synthesis of thymidylate
-
Wahba A. J., Friedkin M. Direct spectrophotometric evidence for the oxidation of tetrahydrofolate during the enzymatic synthesis of thymidylate. J. Biol. Chem. 236:1961.
-
(1961)
J. Biol. Chem.
, vol.236
-
-
Wahba, A.J.1
Friedkin, M.2
-
12
-
-
0024448151
-
Calculation of protein extinction coefficients from amino acid sequence data
-
Gill S. C., von Hippel P. H. Calculation of protein extinction coefficients from amino acid sequence data. Anal. Biochem. 182:1989;319-326.
-
(1989)
Anal. Biochem.
, vol.182
, pp. 319-326
-
-
Gill, S.C.1
Von Hippel, P.H.2
-
13
-
-
0343223060
-
Characterization of the Escherichia coli thy A gene and its amplified thymidylate synthase product
-
Belfort M., Maley G. F. Characterization of the Escherichia coli thy A gene and its amplified thymidylate synthase product. Proc. Natl. Acad. Sci. USA. 80:1983;1858-1861.
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 1858-1861
-
-
Belfort, M.1
Maley, G.F.2
-
14
-
-
0024278707
-
Properties of a defined mutant of Escherichia coli thymidylate synthase
-
Maley G. F., Maley F. Properties of a defined mutant of Escherichia coli thymidylate synthase. J. Biol. Chem. 263:1988;7620-7627.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 7620-7627
-
-
Maley, G.F.1
Maley, F.2
-
15
-
-
0015210983
-
Thymidylate synthetase from amethopterin-resistant Lactobacillus casei
-
Dunlap R. B., Harding N. G. L., Huennekens F. M. Thymidylate synthetase from amethopterin-resistant Lactobacillus casei. Biochemistry. 10:1971;88-97.
-
(1971)
Biochemistry
, vol.10
, pp. 88-97
-
-
Dunlap, R.B.1
Harding, N.G.L.2
Huennekens, F.M.3
-
17
-
-
0014216864
-
The purification and properties of thymidylate synthetase from chick embryo extracts
-
Lorenson M. Y., Maley G. F., Maley F. The purification and properties of thymidylate synthetase from chick embryo extracts. J. Biol. Chem. 242:1967;3332-3346.
-
(1967)
J. Biol. Chem.
, vol.242
, pp. 3332-3346
-
-
Lorenson, M.Y.1
Maley, G.F.2
Maley, F.3
-
18
-
-
0017567159
-
Protective effect of the pteroylpolyglutamates and phosphate on the proteolytic inactivation of thymidylate synthetase
-
Galivan J., Maley F., Baugh C. M. Protective effect of the pteroylpolyglutamates and phosphate on the proteolytic inactivation of thymidylate synthetase. Arch. Biochem. Biophys. 184:1977;346-354.
-
(1977)
Arch. Biochem. Biophys.
, vol.184
, pp. 346-354
-
-
Galivan, J.1
Maley, F.2
Baugh, C.M.3
-
19
-
-
0030011387
-
Thermodynamic stabilization of nucleotide binding to thymidylate synthase by a potent benzoquinazoline folate analogue inhibitor
-
Chen C-H, Davis A. R., Maley F. Thermodynamic stabilization of nucleotide binding to thymidylate synthase by a potent benzoquinazoline folate analogue inhibitor. Biochemistry. 35:1996;8786-8793.
-
(1996)
Biochemistry
, vol.35
, pp. 8786-8793
-
-
Chen, C.-H.1
Davis, A.R.2
Maley, F.3
-
20
-
-
0027477992
-
Biochemical and cellular pharmacology of 1843 U89, a novel benzoquinazoline inhibitor of thymidylate synthase
-
Duch D. S., Banks S., Dev I. K., Ferone R., Dickerson S. H., Heath L. S., Humphreys J., Knick V., Pendergast W., Singer S., Smith G. K., Waters K., Wilson H. R. Biochemical and cellular pharmacology of 1843 U89, a novel benzoquinazoline inhibitor of thymidylate synthase. Cancer Res. 53:1993;810-818.
-
(1993)
Cancer Res.
, vol.53
, pp. 810-818
-
-
Duch, D.S.1
Banks, S.2
Dev, I.K.3
Ferone, R.4
Dickerson, S.H.5
Heath, L.S.6
Humphreys, J.7
Knick, V.8
Pendergast, W.9
Singer, S.10
Smith, G.K.11
Waters, K.12
Wilson, H.R.13
-
21
-
-
0028919297
-
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89
-
Weichsel A., Montfort W. R., Ciesla J., Maley F. Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89. Proc. Natl. Acad. Sci. USA. 92:1995;3493-3497.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3493-3497
-
-
Weichsel, A.1
Montfort, W.R.2
Ciesla, J.3
Maley, F.4
|