Type 4 phosphodiesterase inhibitors attenuate respiratory syncytial virus-induced airway hyper-responsiveness and lung eosinophilia

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 2, 2000, Pages 701-706

  Ikemura, Toshihide ^a   Schwarze, Jurgen ^a   Makela, Mika ^a   Kanehiro, Arihiko ^a   Joetham, Anthony ^a   Ohmori, Kenji ^b   Gelfand, Erwin W ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; EOSINOPHIL CATIONIC PROTEIN; MILRINONE; PHOSPHODIESTERASE INHIBITOR;

AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; LOEFFLER PNEUMONIA; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VIRUS INFECTION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; 4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE; ANIMALS; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTION; CYTOKINES; EOSINOPHILS; FEMALE; HUMANS; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; MILRINONE; NEUTROPHIL INFILTRATION; NEUTROPHILS; PHOSPHODIESTERASE INHIBITORS; PULMONARY EOSINOPHILIA; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; ROLIPRAM;

EID: 0033943602     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Banner KH, Moriggi E, Daros B, Schioppacassi G, Semeraro C and Page CP (1996) The effect of selective phosphodiesterase-3 and phosphodiesterase-4 isoenzyme inhibitors and established anti-asthma drugs on inflammatory cell activation. Br J Pharmacol 119:1255-1261.
2. Banner KH and Page CP (1995) Acute versus chronic administration of phosphodiesterase inhibitors on allergen-induced pulmonary cell influx in sensitized guinea pigs. Br J Pharmacol 114:93-98.
3. Barnette MS, Manning CD, Cieslinski LB, Burman M, Christensen SB and Torphy TJ (1995) The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of PDE IV catalytic activity. J Pharmacol Exp Ther 273:674-679.
4. Blease K, Burke-Gaffney A and Hellewell PG (1998) Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterase 3 and 4. Br J Pharmacol 124:229-237.
5. Chin J, Magoffin RL, Shearer LA, Schieble JH and Lennette EN (1969) Field evaluation of a respiratory syncytial virus vaccine and trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol 89:449-463.
6. Cohan VL, Showell HJ, Fisher DA, Pazoles CJ, Watson JW, Turner CR and Cheng JB (1996) In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633. J Pharmacol Exp Ther 278:1356-1361.
7. Coyle AJ, Uchida D, Ackerman SJ, Mitzner W and Irvin CG (1994) Role of cationic proteins in the airway: Hyperresponsiveness due to airway inflammation. Am J Respir Crit Care Med 150:S63-S71.
8. Cypar D, Stark J and Lemanske RF Jr (1992) The impact of respiratory infections on asthma. Pediatr Clin North Am 39:1259-1276.
9. Danahay H and Broadley KJ (1997) Effects of inhibitors of phosphodiesterase on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration. Br J Pharmacol 129:289-297.
10. Dent G, Giembycz MA, Evans PM, Rabe KF and Barnes PJ (1994) Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: Interaction with the beta adrenoceptor agonist albuterol. J Pharmacol Exp Ther 271:1167-1174.
11. Dent G, Giembycz MA, Rabe KF and Barnes PJ (1991) Inhibition of eosinophil cyclic nucleotide PDE activity and opsonized zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors. Br J Pharmacol 103:1339-1346.
12. Essayan DM, Kagey-Sobotka A, Lichtenstein M and Huang SK (1997) Differential regulation of human antigen-specific Th1 and Th2 lymphocyte responses by isozyme selective cyclic nucleotide phosphodiesterase inhibitors. J Pharmacol Exp Ther 282:506-512.
13. Fujii K, Kohrogi H, Iwagoe H, Hamamoto J, Hirata N, Goto E, Kawano O, Wada K, Yamagata S and Ando M (1997) Novel phosphodiesterase 4 inhibitor T-440 reverses and prevents human bronchial contraction induced by allergen. J Pharmacol Exp Ther 284:162-169.
14. Garofalo R, Kimpen JL, Welliver RC and Ogra PL (1992) Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. J Pediatr 120:28-32.
15. Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, Irvin CG and Gelfand EW (1997) Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 156:766-775.
16. Hatzelmann A, Tenor H and Schudt C (1995) Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions. Br J Pharmacol 114:821-831.
17. Howell RE, Sickels BD and Woeppel SL (1992) Pulmonary antiallergic and bronchodilator effects of isoenzyme-selective phosphodiesterase inhibitors in guinea pigs. J Pharmacol Exp Ther 264:609-615.
18. Kim HW, Canchola JG, Brandt CD, Pyles G, Chanock FM and Parrott RH (1969) Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol 89:422-434.
19. Kimpen JL, Garofalo R, Welliver RC and Ogra PL (1992) Activation of human eosinophils in vitro by respiratory syncytial virus. Pediatr Res 32:160-164.
20. Klemm P, Harris HJ and Perretti M (1995) Effect of rolipram in a murine model of acute inflammation: Comparison with the corticoid dexamethasone. Eur J Pharmacol 281:69-74.
21. Kondo K, Umemura K, Miyaji M and Nakashima M (1999) Milrinone, a phosphodiesterase inhibitor, suppresses intimai thickening after photochemically induced endothelial injury in the mouse femoral artery. Atherosclerosis 142:133-138.
22. Lagente V, Moodley I, Perrrin S, Mottin G and Junien JL (1994) Effects of isoenzyme-selective phosphodiesterase inhibitors on eosinophil infiltration in the guinea pig lung. Eur J Pharmacol 255:253-256.
23. Lagente V, Pruniaux MP, Junien JL and Moodley I (1995) Modulation of cytokine-induced eosinophil infiltration by phosphodiesterase inhibitors. Am J Respir Crit Care Med 151:1720-1724.
24. Manabe H, Akuta K, Sejimo H, Kawasaki H, Nukui E, Ichimura M, Kase H, Kawakita T, Suzuki F, Kitamura S, Sato S and Ohmori K (1997) Antiinflammatory and bronchodilator properties of KF19514, a phosphodiesterase 4 and 1 inhibitor. Eur J Pharmacol 332:97-107.
25. McIntosh K, Ellis EF, Hoffman LS, Lybass TG, Eller JJ and Fulginiti VA (1973) The association of viral and bacterial respiratory infections with the exacerbation of wheezing in young asthmatic children. J Pediatr 82:578-590.
26. Miotla JM, Teixeira MM and Hellewell PG (1998) Suppression of acute lung injury in mice by an inhibitor of phosphodiesterase type 4. Am J Respir Cell Mol Biol 18:411-420.
27. Nicholson KG, Kent J and Ireland DC (1993) Respiratory virus and exacerbation of asthma in adults. Br J Med 307:982-986.
28. Oshiba A, Hamelmann E, Takeda K, Bradley K, Loader JE, Larsen GL and Gelfand EW (1996) Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice. J Clin Invest 97:1398-1408.
29. Raeburn D, Underwood SL, Lewis SA, Woodman VR, Battram CH, Tomkinson A, Sharma S, Jordan R, Souness JE, Webber SE and Karlsson JA (1994) Antiinflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor. Br J Pharmacol 113:1423-1431.
30. Santing RE, Olymulder CG, Molen KV, Meurs H and Zaagsma J (1995) Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs. Eur J Pharmacol 275:75-82.
31. Schwarze J, Cieslewicz G, Hamelmann E, Joetham A, Shultz LD, Lamers MC and Gelfand EW (1999) IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection. J Immunol 162:2997-3004.
32. Schwarze J, Hamelmann E, Bradley KL, Takeda K and Gelfand EW (1997) Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. J Clin Invest 100:226-233.
33. Souness JE, Carter CM, Diocee BK, Hassall GA, Wood LJ and Turner NC (1991) Characterization of guinea pig eosinophil phosphodiesterase activity: Assessment of its involvement in regulating superoxide generation. Biochem Pharmacol 42: 937-945.
34. Tenor H, Hatzelmann A, Church MK, Schudt C and Shute JK (1996) Effects of theophylline and rolipram an leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. Br J Pharmacol 118:1727-1735.
35. Torphy TJ (1998) Phosphodiesterase isoenzymes. Am J Respir Crit Care Med 157: 351-370.
36. Turner CR, Andresen CJ, Smith WB and Watson JW (1994) Effects of rolipram on responses to acute and chronic antigen exposure in monkeys. Am J Respir Crit Care Med 149:1153-1159.
37. Underwood DC, Kotzer CJ, Bochnowicz S, Osborn RR, Luttmann AM, Hay DWP and Theodore TJ (1994) Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. J Pharmacol Exp Ther 270:250-259.