Sustained release microspheres of metoclopramide using poly(D,L-lactide-co-glycolide) copolymers

Journal of Microencapsulation

Volumn 17, Issue 4, 2000, Pages 425-435

  Elkheshen, S A ^a   Radwan, M A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Metoclopramide; Microspheres; Poly(lactide co glycolide); Sustained release

Indexed keywords

BUFFER; COPOLYMER; METOCLOPRAMIDE; MICROSPHERE; PHOSPHATE; POLYGLACTIN;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG RELEASE; ENCAPSULATION; INFRARED RADIATION; MOLECULAR INTERACTION; MOLECULAR WEIGHT; PARTICLE SIZE; VISCOSITY;

EID: 0033934722     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/026520400405688     Document Type: Article

References (17)

1. CHANG, A., and GUPTA, R. K., 1996, Stabilization of tetanus toxoid in poly(DL-lactic-co-glycolic acid) microspheres for the controlled release of antigen. Journal of Pharmaceutical Science, 85, 129-132.
2. CONTI, B., PAVANETTO, F., and GENTA, I., 1992, Use of polylactic acid for the preparation of microencapsulate drug delivery systems. Journal of Microencapsulation, 9, 153-166.
3. DEASY, P. B., FINAN, M. P., and MEEGAN, M. J., 1989, Preparation and characterization of lactic/glycolic acid polymers and copolymers. Journal of Microencapsulation, 6, 369-378.
4. EL CORRE, P., RYTTING, J. H., GAJAN, V., CHEVANNE, F., and EL VERGE, R., 1997, In vitro controlled release kinetics of local anesthetics from poly(D,L-lactide and poly(lactide-co-glycolide) microspheres. Journal of Microencapsulation, 14, 243-255.
5. ELKHESHEN, S., 1996, Simplex lattice design for the optimization of the microencapsulation of a water soluble drug using poly(lactic acid) and poly(lactide-co-glycolide)copolymer. Journal of Microencapsulation, 13, 447-462.
6. JEYANTHI, R., MEHTA, R. C., THANOO, B. C., and DELUCA, P. P., 1997, Effect of processing parameters on the properties of peptide-containing PLGA microspheres. Journal of Microencapsulation, 14, 163-174.
7. JOHNSON, O. L., JAWOROWICZ, W., CLELAND, J. L., BAILEY, L., CHARNIS, M., DUENAS, E., WU, C., SHEPARD, D., MAGIL, S., LAST, T., JONES, A. J. S., and PUTNEY, S. D., 1997, The stabilization and encapsulation of human growth hormone into biodegradable microspheres. Pharmaceutical Research, 17, 730-735.
8. KHIDR, S. H., NIAZY, E. M., and EL-SAYED, Y. M., 1995, Preparation and in-vitro evaluation of sustained-release metoclopramide hydrochloride microspheres. Journal of Microencapsulation, 12, 193-202.
9. LABHASETWAR, V., UNDERWOOD, T., GALLAGHER, M., MURRHY, G., LANGBERG, J., and LEVY, R. J., 1994, Sotalol controlled-release systems for arrhythmias: in-vitro characterization, in vivo drug disposition, and electrophysiologic effects. Journal of Pharmaceutical Science, 83, 156-164.
10. MCGEE, J. P., SINGH, M., LI, X.-M., QIU, H., and O'HAGAN, D. T., 1997, The encapsulation of model protein in poly(D,L lactide-co-glycolide) microparticles of various sizes: an evaluation of process reproducibility. Journal of Microencapsulation, 14, 197-210.
11. PEPPAS, N. A., 1985, Analysis of Fickian and non-Fickian drug release from polymers. Pharmaceutica Acta Helvetiae, 60, 110-111.
12. RIZK, S., DURU, C., GAUDY, D., JACOB, M., COLOMBO, P., and MASSIMO, G., 1994, Natural polymer hydrophilic matrix influencing drug release factors. Drug Developments and Industrial Pharmacy, 20, 2563-2594.
13. SAH, H. K., TODDYWALA, R., and CHIEN, Y. W., 1995, Biodegradable microcapsules prepared by a w/o/w technique: effect of shear force to make a primary w/o emulsion on their morphology and protein release. Journal of Microencapsulation, 12, 59-69.
14. SHAUGHNESSY, A. F., 1985, Potential uses for metoclopramide. Drug Intelligence in Clinical Pharmacy, 19, 723-728.
15. UCHIDA, T., YAGI, Y., ODA, Y., and GOTO, S., 1996, Microencapsulation of ovalbumin in poly(lactide-co-glycolide) by an oil-in-oil (o/o) solvent evaporation method. Journal of Microencapsulation, 13, 509-518.
16. VIGOREAUX, V., and GHALY, E. S., 1994, Fickian and relaxational contribution quantification of drug release in a swellable hydrophilic polymer matrix. Drug Developments and Industrial Pharmacy, 20, 2519-2526.
17. YANG, J., and CLELAND, J. L., 1997, Factors affecting the in vitro release of recombinant human interferon-(rhIFN-) from PLGA microspheres. Journal of Pharmaceutical Sciences, 86, 908-914.