Reproducibility of regional brain metabolic responses to lorazepam

Journal of Nuclear Medicine

Volumn 37, Issue 10, 1996, Pages 1609-1613

  Wang, Gene Jack ^a   Volkow, Nora D ^b   Overall, John ^b   Hitzemann, Robert J ^b   Pappas, Naomi ^b   Pascani, Kathy ^b   Fowler, Joanna S ^b  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b NONE

Author keywords

cerebral glucose metabolism; lorazepam; pharmacological challenge

Indexed keywords

FLUORODEOXYGLUCOSE F 18; LORAZEPAM;

ADULT; ARTICLE; BRAIN METABOLISM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REPRODUCIBILITY; THALAMUS;

ADULT; ANTI-ANXIETY AGENTS; BRAIN; DEOXYGLUCOSE; FLUORINE RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; GLUCOSE; HUMANS; LORAZEPAM; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0029839940     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Volkow ND, Fowler JS. Neuropsychiatric disorders: Investigation of schizophrenia and substance abuse. Semin Nucl Med 1992;12:254-267.
2. Volkow ND, Wang G-J, Hitzemann RJ, et al. Recovery of brain glucose metabolism in detoxified alcoholics. Am J Psych 1994;151:178-183.
3. Mazziotta JC, Phelps ME. Positron emission tomography studies of the brain. In: Phelps ME, Mazziotta J, Schelbert H, eds. Positron emission tomography and autoradiography. New York: Raven Press; 1986:493-579.
4. Sokoloff L. Measurement of local cerebral glucose utilization and its relation to local functional activity in brain. In: Vranic M, Efendic S, Hollenberg CH, eds. Fuel homeostasis and the nervous system. New York: Plenum Press; 1991:21-42.
5. Duara R, Gross-Glenn K, Barker WW, et al. Behavioral activation and the variability of cerebral glucose metabolic measurements. J Cereb Blood Flow Metab 1987;7:266-271.
6. Bartlett EJ, Brodie JD, Wolf AP, Christman DR, Laska E, Meissner M. Reproducibility of cerebral glucose metabolic measurements in resting human subjects. J Cereb Blood Flow Metab 1988;8:502-512.
7. Volkow ND, Hitzemann RJ, Wolf AP, et al. Acute effects of ethanol on regional brain glucose metabolism and transport. Psych Res 1990;35:30-48.
8. Buchsbaum M, Wu J, Haier R, et al. Positron emission tomography, assessment of effects of benzodiazepines on regional glucose metabolic rate in patients with anxiety disorder. Life Sci 1987;40:2393-2400.
9. Morrow AL, Paul SM. Benzodiazepine enhancement of g aminobutyric acid-mediated chloride ion flux in rat brain synaptoneurosomes. J Neurochem 1988;50:302-306.
10. De Wit H, Metz J, Wagner N, Cooper M. Effects of diazepam on cerebral metabolism and mood in normal volunteers. Neuropsychopharmacology 1991;5:33-41.
11. Volkow ND, Wang G-J, Hitzemann RJ, et al. Decreased cerebral response to inhibitory neurotransmission in alcoholics. Am J Psych 1993;150:417-422.
12. Brogden RN, Goa KL. Flumazenil: a preliminary review of ils benzodiazepine antagonist properties, intrinsic activity and therapeutic use. Drags 1988;35:448-467.
13. Volkow ND, Wang G-J, Begleiter H, et al. Regional brain metabolic response to lorazepam in subjects at risk for alcoholism. Alcohol Clin Exp Res 1995;19:510-516.
14. Wang G-J, Volkow ND, Wolf AP, Brodie JD, Hitzemann RJ. Intersubject variability of brain glucose metabolism in young normal males. J Nucl Med 1994;35:1457-1466.
15. Woods JH, Katz JL, Winger G. Benzodiazepines: use, abuse and consequences. Pharmacol Rev 1992;44:154-347.
16. Wang G-J, Volkow ND, Roque C, et al. Functional importance of ventricular enlargement and cortical atrophy in healthy subjects and alcoholics as assessed by PET, MR imaging and neuropsychological testing. Radiology 1993;186:59-65.
17. Haggard EA. Intraclass correlation and the analysis of variance. New York: Dryden Press; 1958.
18. Winer, BJ. Statistical principles in experimental design. New York: McGraw-Hill 1972:217-280.
19. Volkow ND, Wang G-J, Hitzemann RJ, et al. Depression of thalamic metabolism by lorazepam is associated with sleepiness. Neuropsychopharmacology 1995;12:123-132.
20. A/BZ receptors subtypes. In: Biggio G, Concas A, Costa E, eds. GABAergic synaptic transmission: molecular, pharmacological and clinical aspects. New York: Raven Press; 1992:29-40.
21. Foster NL, VanDerSpek AFL, Aldrich MS, et al. The effect of diazepam sedation on cerebral glucose metabolism in Alzheimer's disease as measured using positron emission tomography. J Cereb Blood Flow Metab 1987;7:415-420.
22. Gur RC, Gur RE, Resnick SM, Skolnick BE, Alavi A, Reivich M. The effect of anxiety on cortical cerebral blood flow and metabolism. J Cereb Blood Flow Metab 1987;7:173-177.
23. Henauer SA, Gallaher EJ, Hollister LE. Long-lasting single-dose tolerance to neurologic deficits induced by diazepam. Psychopharmacology 1984;82:161-163.