High-dose carmustine, thiotepa and etoposide followed by autologous bone marrow rescue for the treatment of high risk central nervous system tumors

Bone Marrow Transplantation

Volumn 26, Issue 2, 2000, Pages 153-160

  Papadakis, V ^a   Dunkel, I J ^a   Cramer, L D ^a   Kramer, E ^b   Papadopoulos, E ^a   Goldman, S ^c   Packer, R J ^d   Willoughby, M ^e   Baker, D ^e   Garvin, J ^f   Strandjord, S ^g   Coccia, P ^h   Kaplan, A M ⁱ   Klemperer, M ^j   Finlay, J L ^k,l  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Department of Anesthesiology   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^e PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^f NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^g EAST CAROLINA UNIVERSITY   (United States)

^h UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

ⁱ PHOENIX CHILDREN'S HOSPITAL   (United States)

^j JOHNS HOPKINS ALL CHILDREN S HOSPITAL   (United States)

^k NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^l Division of Pediatric Oncology   (United States)

more..

Author keywords

Bone marrow transplantation; Carmustine; CNS tumors; Etoposide; Glioma; Thiotepa

Indexed keywords

CARMUSTINE; ETOPOSIDE; NITROSOUREA; THIOTEPA;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW METASTASIS; BRAIN STEM TUMOR; CANCER INFILTRATION; CANCER MORTALITY; CANCER SURVIVAL; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; CLINICAL ARTICLE; DERMATITIS; DIARRHEA; FEMALE; FEVER; GLIOMA; HALLUCINATION; HEMIPARESIS; HIGH RISK PATIENT; HUMAN; INFANT; LIVER VENOOCCLUSIVE DISEASE; LUNG TOXICITY; MALE; MEDULLOBLASTOMA; MUCOSA INFLAMMATION; NEPHROTOXICITY; NEUROTOXICITY; PANCYTOPENIA; POSTERIOR CRANIAL FOSSA TUMOR; PRIORITY JOURNAL; RECURRENT DISEASE; REMISSION; SEIZURE; SIDE EFFECT; SPINAL CORD TUMOR; STOMATITIS;

EID: 0033931520     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1702475     Document Type: Article

References (32)

1. Finlay JL, Boyett JM, Yates AJ et al. Randomized phase III trial in childhood high grade astrocytoma comparing vincristine, lomustine and prednisone with the eight-drugs-in-1-day regimen. Clin Oncol 1995; 13: 112-123.
2. Torres CF, Rebsamen S, Silber JH et al. Surveillance scanning of children with medulloblastoma. New Engl J Med 1994; 330: 892-895.
3. Finlay JL, Goins SC. Brain tumors in children. III. Advances in chemotherapy. Am J Pediatr Hematol Oncol 1987; 9: 264-271.
4. Finlay JL, Goins SC, Uteg R, Giese WL. Progress in the management of childhood brain tumors. Hematol Oncol Clin North Am 1987; 1: 753-776.
5. Sposto R, Ertel IJ, Jenkin RDT et al. The effectiveness of chemotherapy for treatment of high grade astrocytoma in children. Results of a randomized trial. A report from the Children's Cancer Study Group. J Neurooncol 1989; 7: 165-177.
6. Allen JC, Helson L, Jereb B. Preradiation chemotherapy for newly diagnosed childhood brain tumors. A modified Phase II trial. Cancer 1983; 52: 2001-2006.
7. Kovnar EH, Kellie SJ, Horowitz ME et al. Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study. J Clin Oncol 1990; 8: 330-336.
8. Finlay JF, Goldman S, Wong MC et al. Pilot study of high-dose thiotepa and etoposide with autologous bone marrow rescue in children and young adults with recurrent CNS tumors. J Clin Oncol 1996; 14: 2495-2503.
9. Fine HA, Antman KH. High-dose chemotherapy with autologous bone marrow transplantation in the treatment of high grade astrocytomas in adults: therapeutic rationale and clinical experience. Bone Marrow Transplant 1992; 10: 315-321.
10. Donelli MG, Zucchetti M, D'Incalci M. Do anticancer agents reach the tumor target in the human brain? Cancer Chemother Pharmacol 1992; 30: 251-260.
11. Postmus PE, Holthuis JJ, Haaxma-Reiche H et al. Penetration of VP 16-213 into cerebrospinal fluid after high-dose intravenous administration. J Clin Oncol 1984; 2: 215-220.
12. Heideman RL, Packer RJ, Reaman GH et al. A phase II evaluation of thiotepa in pediatric central nervous system malignancies. Cancer 1993; 72: 271-275.
13. Finlay JL, Knipple J, Turski P et al. Pharmacokinetic studies of thiotepa in dogs following delivery by various routes. J Neurooncol 1986; 4: 110 (Abstr.).
14. Heideman RL, Cole DE, Balis F et al. Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: evidence for dose-dependent plasma clearance of thiotepa. Cancer Res 1989; 49: 736-741.
15. Stewart DJ, Richard MT, Hugenholtz H et al. Penetration of VP-16 (etoposide) into human intracerebral and extracerebral tumors. J Neurooncol 1984; 2: 133-139.
16. Edwards MS, Levin MA, Seager ML et al. Phase II evaluation of thiotepa for treatment of central nervous system tumors. Cancer Treat Rep 1979; 73: 1419-1421.
17. Radice PA, Bunn PAJ, Ihde DC. Therapeutic trials with VP-16-213 and VM-26: active agents in small cell lung cancer, non-Hodgkin's lymphoma and other malignancies. Cancer Treat Rep 1979; 63: 1231-1239.
18. Tirelli U, D'Incalci M, Canetta R et al. Etoposide (VP-16-213) in malignant brain tumors. A phase II study. J Clin Oncol 1984; 2: 432-437.
19. Mastronardi L, Ferrante L, Lunardi P et al. Association between neuroepithelial tumor and multiple intestinal polyposis (Turcot's syndrome): report of a case and critical analysis of the literature. Neurosurgery 1991; 28: 449-452.
20. Finlay JL, August C, Packer R et al. High-dose multi-agent chemotherapy followed by bone marrow 'rescue' for malignant astrocytomas of childhood and adolescence. J Neurooncol 1990; 9: 239-248.
21. Dunkel IJ, Garvin JHJ, Goldman S et al. High dose chemotherapy with autologous bone marrow rescue for children with diffuse pontine brain tumors. J Neuro-oncol 1998; 37: 67-73.
22. Stragliotto G, Packer RJ, Rausen AR et al. Outcome of postradiation secondary glioblastoma in children (Letter to the Editor). Med Pediatr Oncol 1998; 30: 194-196.
23. Gururangan S, Dunkel IJ, Goldman S et al. Myeloablative chemotherapy with autologous bone marrow rescue in young children with recurrent malignant brain tumors. J Clin Oncol 1998; 16: 2486-2493.
24. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. Am J Stat Assoc 1958; 53: 457-481.
25. Savage IR. Contributions to the theory of rank order statistics-the two sample case. Ann Math Stat 1956; 27: 590-615.
26. Gehan EA. A generalized Wilcoxon test for comparing arbitrarily singly-censored samples. Biomedica 1965: 52: 203-223.
27. Fine HA, Dear KBG, Loeffler JS et al. Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 1993; 71: 2585-2591.
28. Finlay JL, Geyer JR, Turski PA et al. Pre-irradiation chemotherapy in children with high-grade astrocytoma: tumor response to two cycles of the 'eight-drugs-in-one-day' regimen: a Children's Cancer Group study CCG-945. J Neurol 1994; 21: 255-265.
29. Hochberg FH, Parker LM, Takvorian T et al. High-dose BCNU with autologous bone marrow rescue for recurrent glioblastoma multiforme. J Neurosurg 1981; 54: 455-459.
30. Dunkel IJ, Boyett JM, Yates A et al. High-dose carboplatin. thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. J Clin Oncol 1998; 16: 222-228.
31. Mason WP, Grovas A, Halpern S et al. Intensive chemotherapy and bone marrow rescue for young children with newly diagnosed malignant brain tumors. J Clin Oncol 1998; 16: 210-221.
32. Dohrmann GJ, Farwell Jr, Flannery JT. Glioblastoma multiforme in children. J Neurosurg 1985; 62: 811-815.