Induction of apoptosis in BPH stromal cells by adenoviral-mediated overexpression of caspase-7

Journal of Urology

Volumn 164, Issue 2, 2000, Pages 518-525

  Marcelli, Marco ^a   Shao, T C ^a   Li, Xiaoying ^a   Yin, Heather ^a   Marani, Michela ^a   Denner, Larry ^a   Teng, Babie ^a   Cunningham, Glenn R ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b NONE   (United States)

Author keywords

Apoptosis; Benign prostate hyperplasia; Caspases

Indexed keywords

CASPASE 7;

ADENOVIRUS; APOPTOSIS; ARTICLE; CELL CULTURE; CORRELATION FUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; VIRUS INFECTION;

EID: 0033927781     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)67416-2     Document Type: Article

References (35)

1. Rohr, H. P. and Bartsch, G.: Human benign prostatic hyperplasia: a stromal disease? New perspectives by quantitative morphology. Urology, 16: 625, 1980
2. Shapiro, E., Becich, M. J., Hartanto, V. and Lepor, H.: The relative proportion of stromal and epithelial hyperplasia is related to the development of symptomatic benign prostate hyperplasia. J Urol, 147: 1293, 1992
3. Ishigooka, M., Hayami, S., Suzuki, Y., Hashimoto, T., Sasagawa, I. and Nakada, T.: Age-related changes of histological composition in established benign prostatic hyperplasia. Eur Urol, 29: 85, 1996
4. Bierhoff, E., Walljasper, U., Hofmann, D., Vogel, J., Wernert, N. and Pfeifer, U.: Morphological analogies of fetal prostate stroma and stromal nodules in BPH. Prostate, 31: 234, 1997
5. Tunn, S., Nass, R., Ekkernkamp, A., Schulze, H. and Krieg, M.: Evaluation of average life span of epithelial and stromal cells of human prostate by superoxide dismutase activity. Prostate, 15: 263, 1989
6. Kyprianou, N., Tu, H. and Jacobs, S. C.: Apoptotic versus pro-liferative activities in human benign prostatic hyperplasia, Hum Pathol, 27: 668, 1996
7. Claus, S., Berges, R., Senge, T. and Schulze, H.: Cell kinetic in epithelium and stroma of benign prostatic hyperplasia [see comments], J Urol., 158: 217-21, 1997
8. Kyprianou, N., Litvak, J. P., Borkowski, A., Alexander, R. and Jacobs, S. C.: Induction of prostate apoptosis by doxazosin in benign prostatic hyperplasia, J Urol, 159: 1810, 1998
9. Kerr, J. F., Wyllie, A. H. and Currie, A. R.: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer, 26: 239, 1972
10. Wyllie, A. H., Kerr, J. F. and Currie, A. R.: Cell death: the significance of apoptosis. Int Rev Cytol, 68: 251, 1980
11. Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M. and Green, D. R.: Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: ,nhibition by overexpression of Bcl-2 and Abl. J Exp Med, 182: 1545, 1995
12. Ashkenazi, A. and Dixit, V.: Death receptors: signaling and modulation. Science, 281: 1305, 1998
13. Liu, X., Kim, C., Yang, J., Jemmerson, R. and Wang, X.: Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86: 147, 1996
14. Cohen, G. M.: Caspases: the executioners of apoptosis. Biochem J, 326: 1, 1997
15. Fraser, A. and Evan, G.: A license to kill. Cell, 85: 781, 1996
16. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., Litwack, G. and Alnemri, E. S.: Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE- like cysteine proteases. Proc Natl Acad Sci USA, 93: 14486, 1996
17. Wyllie, A.: Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature, 284: 555, 1980
18. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., Chapman, K. T. and Nicholson, D. W.: A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem, 272: 17907, 1997
19. Marcelli, M., Cunnigham, G., Haidacher, S., Padayatty, S., Sturgis, L., Kagan, C. and Denner, L.: Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP. Cancer Res, 58: 76, 1998
20. Marcelli, M., Cunningham, G., Walkup, M., He, Z., Sturgis, L., Kagan, C., Mannucci, R., Nicoletti, I., Teng, B. and Denner, L.: Signaling pathway activated during apoptosis of the prostate cancer cell line LNCaP: overexpression of caspase-7 as a new gene therapy strategy for the treatment of prostate cancer. Cancer Res, 59: 398, 1999
21. Fernandes-Alnemri, T., Litwack, G. and Alnemri, E.: CPP32, a novel human apoptotic protein with homology to C. elegans cell death protein Ced-3 and mammalian interleukin-1β-converting enzyme. J Biol Chem, 269: 30761, 1994
22. Fernandes-Alnemri, T., Takahashi, A., Armstrong, R., Krebs, J., Lawrence, F., Tomaselli, K., Wang, L., Yu, Z., Croce, C., Salvesen, G., Earnshaw, W., Litwack, G. and Alnemri, E.: Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res, 55: 6045, 1995
23. Teng, B., Blumenthal, S., Forte, T., Navatnam, N., Scott, J., Gotto, A. and Chan, L.: Adenovirus-mediated gene transfer of rat apolipoprotein B mRNA-editing protein in mice virtually eliminates apoplipoprotein B-100 and normal low density lipoprotein production, J Biol Chem, 269: 29395, 1994
24. Smith, T., Mehaffey, M., Kayda, D., Saunders, J., Yei, S., Trapnell, B., McClelland, A. and Kaleko, M.: Adenovirus-mediated expression of therapeutic plasma levels of human factor IX in mice. Nature Genet, 5: 397, 1993
25. McGrory, W., Bautista, D. and Graham, F.: A simple technique for the rescue of early region 1 mutations into infectious human adenovirus type 5. Virology, 163: 614, 1988
26. Miura, M., Zhu, H., Rotello, R., Hartwieg, E. and Yuan, J.: Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell, 75: 653, 1993
27. Wang, L., Miura, M., Bergeron, L., Zhu, H. and Yuan, J.: Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell, 78: 739, 1994
28. Duan, H., Orth, K., Chinnaiyan, A., Poirier, G., Froelich, C., He, W-W. and Dixit, V.: ICE-LAP6, a novel member of the ICE/ Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem, 271: 16720, 1996
29. Srinivasula, S., Ahmad, M., MacFarlane, M., Huang, Z. L., Fernandez-Alnemri, T. and Alnemri, E.: Generation of constitutively active recombinant caspases-3 and -6 by rearrangment of their subunit. J Biol Chem, 273: 10107, 1998
30. Krajewska, M., Wang, H. G., Krajewski, S., Zapata, J. M., Shabaik, A., Gascoyne, R. and Reed, J. C.: Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. Cancer Res, 57: 1605, 1997
31. Vaux, D. and Strasser, A.: The molecular biology of apoptosis. Proc Natl Acad Sci USA, 93: 2239, 1996
32. Greenberg, N., DeMayo, F., Sheppard, P., Barrios, R., Lebovitz, R., Finegold, M., Angelopoulou, R., Dodd, J., Rosen, M. and Matusik, R.: The rat probasin gene promoter directs hormonally- and developmentally-regulated expression of a heterologous gene specifically to the prostate in transgenic mice. Mol Endocrinol, 8: 230, 1994
33. Wei, C., Willis, R. A., Tilton, B. R., Looney, R. J., Lord, E. M., Barth, R. K. and Frelinger, J. G.: Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy. Proc Natl Acad Sci USA, 94: 6369, 1997
34. Cleutjens, K. B., van der Korput, H. A., van Eekelen, C. C., van Rooij, H. C., Faber, P. W., and Trapman, J. An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol Endocrinol, 11: 148, 1997
35. Gotoh, A., Ko, S.-C., Shirakawa, T., Cheon, J., Kao, C., Miyamoto, T., Gardner, T., Ho, L.-J., Cleutjens, C., Trapman, J., Graham, F. and Chung, L.: Development of a prostate-specific antigen promoter-base gene therapy for androgen-independent human prostate cancer. J Urol, 160: 220, 1998