Analysis of the TCRBV repertoire of T cells in normal, human skin: Evidence for a restricted diversity

Journal of Investigative Dermatology

Volumn 115, Issue 1, 2000, Pages 66-73

  Menssen, Antje ^a,c   Vollmer, Sigrid ^a   Trommler, Paul ^a   Sander, Christian ^a   Prinz, Jörg C ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clonal expansion; Skin; T cell receptor diversity; T lymphocytes

Indexed keywords

T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADULT; AGED; ARTICLE; BIODIVERSITY; BODY SURFACE; CELL SELECTION; CONTROLLED STUDY; EPITHELIUM; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; INFANT; MALE; MULTIGENE FAMILY; PERIPHERAL LYMPHOCYTE; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; T LYMPHOCYTE RECEPTOR GENE; T LYMPHOCYTE SUBPOPULATION;

EID: 0033924766     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00982.x     Document Type: Article

References (54)

1. Baker BS, Garioch JJ, Hardman C, Powles A, Fry L: Induction of cutaneous lymphocyte-associated antigen expression by group A streptococcal antigens in psoriasis. Arch Dermatol Res 289:671, 1997
2. Bandeira A, Mota-Santos T, Itohara S, Degermann S, Heusser C, Tonegawa S, Coutinho A: Localization of γδ-T cells to the intestinal epithelium is independent of normal microbial colonization. J Exp Med 168:1993, 1990
3. Blohme I, Larko O: Premalignant and malignant skin lesions in renal transplant patients. Transplantation 37:165, 1984
4. Bos JD: The skin as an organ of immunity. Clin Exp Immunol 107(Suppl. 1):3, 1997
5. Bos JD, Kapsenberg ML: The skin immune system: progress in cutaneous biology. Immunol Today 14:75, 1993
6. Bos JD, Zonneveld I, Das PK, Krieg SR, van der Loos CM, Kapsenberg ML: The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J Invest Dermatol 88:569, 1987
7. Bos JD, de Boer OJ, Tibosch E, Das PK, Pals ST: Skin-homing T lymphocytes: detection of cutaneous lymphocyte-associated antigen (CLA) by HECA-452 in normal human skin. Arch Dermatol Res 285:179, 1993
8. Butcher EC, Picker LJ: Lymphocyte homing and homeostasis. Science 272:60, 1996
9. Callahan JE, Kappler JW, Marrack P: Unexpected expansions of CD8-bearing cells in old mice. J Immunol 151:6657, 1993
10. Cavani A, Mei D, Guerra E, et al: Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells. J Invest Dermatol 111:621, 1998
11. Choi Y, Kotzin B, Herron L, Callahan J, Marrack P, Kappler J: Interaction of Staphylococcus aureus toxin 'superantigens' with human T cells. Proc Natl Acad Sci USA 86:8941, 1989
12. Davis MM, Bjorkman PJ: T-cell antigen receptor genes and T-cell recognition. Nature 334:395, 1988
13. Duijvestijn AM, Horst E, Pals ST, et al: High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452. Am J Pathol 130:147, 1988
14. Dwyer E, Itescu S, Winchester R: Characterization of the primary structure of TCR β chains in cells infiltrating the salivary gland in the sicca syndrome of HIV-1 infection. Evidence of antigen-driven clonal selection suggested by restricted combinations of Vβ Jβ gene segment usage and shared somatically encoded amino acid residues. J Clin Invest 92:495, 1993
15. Feeney AJ: Junctional sequences of fetal T cell receptor beta chains have few N regions. J Exp Med 174:115, 1991
16. Foster CA, Yokozeki H, Rappersberger K, et al: Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor. J Exp Med 171:997, 1990
17. Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC: Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134, 1996
18. Garcia KC, Degano M, Stanfield RL, et al: An alpha/beta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 274:209, 1996
19. Gellert M: Recent advances in understanding V (D) J recombination. Adv Immunol 64:39, 1997
20. Havran WL, Boismenu R: Activation and function of gamma delta T cells. Curr Opin Immunol 6:442, 1994
21. Hedrick SM, Engel I, McElligott DL, Fink PJ, Hsu HM, Hansburg D, Matis LA: Selection of amino acid sequences in the beta chains of the T cell antigen receptor. Science 239:1541, 1988
22. Horrocks C, Holder JE, Berth-Jones J, Camp RD: Antigen-independent expansion of T cells from psoriatic skin lesions: phenotypic characterization and antigen reactivity. Br J Dermatol 137:331, 1997
23. Kappler J, Kotzin B, Herron L, et al: V beta-specific stimulation of human T cells by staphylococcal toxins. Science 244:811, 1989
24. Leung DY, Gately M, Trumble A, Ferguson Darnell B, Schlievert PM, Picker LJ: Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J Exp Med 181:747, 1995
25. Leyden JJ, McGinley KJ, Nordstrom KM, Webster GF: Skin microflora. J Invest Dermatol 88:65s, 1987
26. Linton P-J, Haynes L, Tsui L, Zhang X, Swain S: From naive to effector - alterations with aging. Immunol Rev 160:9, 1997
27. Marguerie C, Lunardi C, So A: PCR-based analysis of the TCR repertoire in human autoimmune diseases. Immunol Today 13:336, 1992
28. Marrack P, Kappler J: The staphylococcal enterotoxins and their relatives. Science 248:705, 1990
29. Maryanski JL, Jongeneel CV, Bucher P, Casanova JL, Walker PR: Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. Immunity 4:47, 1996
30. McHeyzer-Williams MG, Davis MM: Antigen-specific development of primary and memory T cells in vivo. Science 268:106, 1995
31. Menssen A, Trommler P, Vollmer S, et al: Evidence for an antigen-specific cellular immune response in skin lesions of patients with psoriasis vulgaris. J Immunol 155:4078, 1995
32. Miller RA: The aging immune system: primer and prospectus. Science 273:70, 1996
33. Moss PA, Bell JI: Sequence analysis of the human alpha beta T-cell receptor CDR3 region. Immunogenetics 42:10, 1995
34. Paliard X, West SG, Lafferty JA, Clements JR, Kappler JW, Marrack P, Kotzin BL: Evidence for the effects of a superantigen in rheumatoid arthritis. Science 251:325, 1991
35. Panzara MA, Oksenberg JR, Steinman L: The polymerase chain reaction for detection of T-cell antigen receptor expression. Curr Opin Immunol 4:205, 1992
36. Picker LJ, Michie SA, Rott LS, Butcher EC: A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites. Am J Pathol 136:1053, 1990
37. Picker LJ, Treer JR, Ferguson Darnell B, Collins PA, Bergstresser PR, Terstappen LW: Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells. J Immunol 150:1122, 1993
38. Posnett DN, Sinha R, Kabak S, Russo C: Clonal populations of T cells in normal elderly humans: the T cell equivalent to 'benign monoclonal gammapathy'. J Exp Med 179:609, 1994
39. Prinz JC, Gross B, Vollmer S, Trommler P, Strobel I, Meurer M, Plewig G: T cell clones from psoriasis skin lesions can promote keratinocyte proliferation in vitro. Eur J Immunol 24:593, 1994
40. Quiros Roldan E, Sottini A, Bettinardi A, Albertini A, Imberti L, Primi D: Different TCRBV genes generate biased patterns of V-D-J diversity in human T cells. Immunogenetics 41:91, 1995
41. Rock EP, Sibbald PR, Davis MM, Chien YH: CDR3 length in antigen-specific immune receptors. J Exp Med 179:323, 1994
42. Rosenberg WM, Moss PAH, Bell JI: Variation in human T cell receptor Vβ and Jβ repertoire: analysis using anchor polymerase chain reaction. Eur J Immunol 22:541, 1992
43. Schwab R, Szabo P, Manavalan JS, et al: Expanded CD4+ and CD8+ T cell clones in elderly humans. J Immunol 158:4493, 1997
44. Steinle A, Reinhardt C, Jantzer P, Schendel DJ: In vivo expansion of HLA-B35 alloreactive T cells sharing homologous T cell receptors: evidence for maintenance of an oligoclonally dominated allospecificity by persistent stimulation with an autologous MHC/peptide complex. J Exp Med 181:503, 1995
45. Streilein JW: Lymphocyte traffic, T-cell malignancies and the skin. J Invest Dermatol 71:167, 1978
46. Sunderkotter C, Kalden H, Luger TA: Aging and the skin immune system. Arch Dermatol 133:1256, 1997
47. + Type 2 T cell subsets in human leismaniasis have distinct T cell receptor repertoires. J Immunol 151:7095, 1995
48. Van Kerckhove CGJ, Russel K, Deusch K, Reich AK, Bhan H, DerSimonian, Brenner MB: Oligoclonality of human intestinal intraepithelial T cells. J Exp Med 175:57, 1992
49. Vollmer S, Menssen A, Trommler P, Schendel D, Prinz JC: T lymphocytes derived from skin lesions of patients with psoriasis vulgaris express a novel cytokine pattern that is distinct from that of T helper type 1 and T helper type 2 cells. Eur J Immunol 24:2377, 1994
50. Walder BK, Robertson MR, Jeremy D: Skin cancer and immunosuppression. Lancet 2:1282, 1971
51. Wang X, Golkar L, Uyemura K, et al: T cells bearing Vβ6 T cell receptors in the cell-mediated immune response to Mycobacterium leprae. J Immunol 151:7105, 1993
52. Wang XH, Ohmen JD, Uyemura K, Rea TH, Kronenberg M, Modlin RL: Selection of T lymphocytes bearing limited T-cell receptor β chains in the response to a human pathogen. Proc Natl Acad Sci USA 90:188, 1993
53. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, Modlin RL: Defining protective responses to pathogens: cytokine profile in leprosy lesions. Science 254:277, 1991
54. Zhou T, Edwards CK3rd, Mountz JD: Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J Exp Med 182:129, 1995