메뉴 건너뛰기




Volumn 63, Issue 2, 2000, Pages 210-212

Development of novel anti-HCV therapies: HCV protease, helicase, and polymerase as therapeutic targets

Author keywords

Anti HCV; HCV; Helicase; IFN; Polymerase; Protease; Ribavirin

Indexed keywords

ALPHA INTERFERON; ENZYME INHIBITOR; HELICASE; REBETRON; RNA DIRECTED RNA POLYMERASE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; VIRUS ENZYME;

EID: 0033917757     PISSN: 00015644     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (5)

References (16)
  • 1
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • CHOO Q.L., KUO G., WEINER A.J., OVERBY L.R., BRADLEY D.W., HOUGHTON M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science, 1989, 244 : 59-362.
    • (1989) Science , vol.244 , pp. 59-362
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 5
    • 0032585237 scopus 로고    scopus 로고
    • Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IHIT)
    • POYNARD T., MARCELLIN P., LEE S.S., NIEDERAU C., MINUK G.S., IDEO G., BAIN V. HEATHCOTE J., ZEUZEM S. TREPO C., ALBRECHT J. Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IHIT). Lancet, 1998, 352 : 1426-32.
    • (1998) Lancet , vol.352 , pp. 1426-1432
    • Poynard, T.1    Marcellin, P.2    Lee, S.S.3    Niederau, C.4    Minuk, G.S.5    Ideo, G.6    Bain, V.7    Heathcote, J.8    Zeuzem, S.9    Trepo, C.10    Albrecht, J.11
  • 6
    • 0032547944 scopus 로고    scopus 로고
    • Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group
    • DAVIS G.L., ESTEBAN-MUR R., RUSTGI V., HOEFS J., GORDON S.C., TREPO C., SHIFFMAN M.L., ZEUZEM S., CRAXI A., LING M.H. ALBRECHT J. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group. N. Engl. J. Med., 1998, 339 : 1493-9.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1493-1499
    • Davis, G.L.1    Esteban-Mur, R.2    Rustgi, V.3    Hoefs, J.4    Gordon, S.C.5    Trepo, C.6    Shiffman, M.L.7    Zeuzem, S.8    Craxi, A.9    Ling, M.H.10    Albrecht, J.11
  • 7
    • 0027414062 scopus 로고
    • Characterization of the hepatitis C virus-encoded serine protease : Determination of proteinase-dependent polyprotein cleavage
    • GRAKOUI A., MCCOURT D.W., WYCHOWSKI C., FEINSTONE S.M., RICÉ C.M. Characterization of the hepatitis C virus-encoded serine protease : determination of proteinase-dependent polyprotein cleavage. J. Virol. 1993, 67 : 2832-2843.
    • (1993) J. Virol. , vol.67 , pp. 2832-2843
    • Grakoui, A.1    McCourt, D.W.2    Wychowski, C.3    Feinstone, S.M.4    Ricé, C.M.5
  • 8
    • 0028241489 scopus 로고
    • Kinetics and structural analysis of hepatitis C virus polyprotein processing
    • BARTENSCHLAGER R., RHLBORN-LAAKE L., MOUS J., JACOBSON H. Kinetics and structural analysis of hepatitis C virus polyprotein processing. J. Virol., 1994, 68 : 5045-5055.
    • (1994) J. Virol. , vol.68 , pp. 5045-5055
    • Bartenschlager, R.1    Rhlborn-Laake, L.2    Mous, J.3    Jacobson, H.4
  • 9
    • 0029076837 scopus 로고
    • The N-terminal region of hepatitis C virus non-structural protein (NS3) is essential for stable complex formation with NS4A
    • SATOH S., TANJI Y., HIJIKATA M., KIMURA K., SHIMOTOHNO K. The N-terminal region of hepatitis C virus non-structural protein (NS3) is essential for stable complex formation with NS4A. J. Virol., 1995, 69 : 4255-4260.
    • (1995) J. Virol. , vol.69 , pp. 4255-4260
    • Satoh, S.1    Tanji, Y.2    Hijikata, M.3    Kimura, K.4    Shimotohno, K.5
  • 11
    • 0029970903 scopus 로고    scopus 로고
    • The helicase acclivity associated with hepatitis C virus non-structural protein 3 (NS3)
    • TAI C.L., CHI W.K., CHEN D.S., HWANG L.H. The helicase acclivity associated with hepatitis C virus non-structural protein 3 (NS3). J. Virol., 1996, 70 : 8477-8484.
    • (1996) J. Virol. , vol.70 , pp. 8477-8484
    • Tai, C.L.1    Chi, W.K.2    Chen, D.S.3    Hwang, L.H.4
  • 13
    • 0030051777 scopus 로고    scopus 로고
    • Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
    • BEHRENS S.E., TOMEI L., DE FRANCESCO R. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J., 1996, 15 : 12-22.
    • (1996) EMBO J. , vol.15 , pp. 12-22
    • Behrens, S.E.1    Tomei, L.2    De Francesco, R.3
  • 14
    • 1842289764 scopus 로고    scopus 로고
    • Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification ot amino acid sequence motifs essential for enzymatic activity
    • LOHMANN V., KORNER F., HERIAN U., BARTENSCHLAGER R. Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification ot amino acid sequence motifs essential for enzymatic activity. J. Virol., 1997, 71 : 8416-28.
    • (1997) J. Virol. , vol.71 , pp. 8416-8428
    • Lohmann, V.1    Korner, F.2    Herian, U.3    Bartenschlager, R.4
  • 15
    • 0032902564 scopus 로고    scopus 로고
    • Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli
    • FERRARI E., WRIGHT-MINOGUE J., FANG J.W., BAROUDY B.M., LAU J.Y., HONG Z. Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli. J. Virol., 1999, 73 : 1649-54.
    • (1999) J. Virol. , vol.73 , pp. 1649-1654
    • Ferrari, E.1    Wright-Minogue, J.2    Fang, J.W.3    Baroudy, B.M.4    Lau, J.Y.5    Hong, Z.6
  • 16
    • 0032876683 scopus 로고    scopus 로고
    • Crystal structure of the RNA-dependent RNA plymrease from hepatitis C virus reveals a fully encircled active site
    • LEESBURG C.A., CABLE M.B., FERRARI E., HONG Z., MANNARION A.F., WEBER P.C. Crystal structure of the RNA-dependent RNA plymrease from hepatitis C virus reveals a fully encircled active site. Nature Structural Biology, 1999, 10 : 937-943.
    • (1999) Nature Structural Biology , vol.10 , pp. 937-943
    • Leesburg, C.A.1    Cable, M.B.2    Ferrari, E.3    Hong, Z.4    Mannarion, A.F.5    Weber, P.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.