PACAP-38 activates parasympathetic nerves in isolated, blood-perfused dog atria

European Journal of Pharmacology

Volumn 315, Issue 3, 1996, Pages 289-296

  Yonezawa, Takanori ^a   Furukawa, Yasuyuki ^a   Lakhe, Manoj ^a   Nagashima, Yoshito ^a   Hirose, Masamichi ^a   Chiba, Shigetoshi ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetylcholine; Chronotropism; Dog; Heart; Inotropism; PACAP (6 38) (pituitary adenylate cyclase activating polypeptide (6 38)); PACAP 38 (pituitary adenylate cyclase activating polypeptide 38); Parasympathetic nervous system

Indexed keywords

ACETYLCHOLINE; ATROPINE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; NORADRENALIN; PHYSOSTIGMINE; PROPRANOLOL; TETRODOTOXIN; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR;

ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; CHRONOTROPISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DRUG EFFECT; HEART ATRIUM CONTRACTION; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; SINUS RHYTHM;

ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART ATRIA; NEUROPEPTIDES; NEUROPROTECTIVE AGENTS; PARASYMPATHETIC NERVOUS SYSTEM; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE;

EID: 0030597316     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00609-7     Document Type: Article

References (28)

1. Arimura, A., A. Somogyvari-Vigh, A. Miyata, K. Mizuno, D.H. Coy and C. Kitada, 1991, Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testis, Endocrinology 129, 2787.
2. Chiba, S., 1976, Effect of pentobarbital, verapamil and manganese on the frequency-force relationship of the isolated atrium and ventricle of the dog heart, Eur. J. Pharmacol. 40, 225.
3. Chiba, S., T. Kimura and K. Hashimoto, 1975, Effects of verapamil on the blood-perfused, isolated atrium preparation of the dog heart, Jpn. Heart J. 16, 709.
4. De Ferrari, G.M., E. Vanoli and P.J. Schwartz, 1993, Vagal activity and ventricular fibrillation, in: Vagal Control of the Heart: Experimental Basis and Clinical Implications, eds. M.N. Levy and P.J. Schwartz (Futura, New York, NY) p. 613.
5. Furukawa, Y., M. Kobayashi and S. Chiba, 1980, A pharmacologic analysis of chronotropic and inotropic responses to direct electrical stimulation of the isolated, blood-perfused canine atrium, Jpn. Heart J. 21, 873.
6. Harmar, T. and E. Lutz, 1994, Multiple receptors for PACAP and VIP, Trends Pharmacol. Sci. 15, 97.
7. Ishihara, T., R. Shigemoto, K. Mori, K. Takahashi and S. Nagata, 1992, Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide, Neuron 8, 811.
8. Ishizuka, Y., K. Kashimoto, T. Mochizuki, K. Sato, K. Ohshima and N. Yanaihara, 1992, Cardiovascular and respiratory actions of pituitary adenylate cyclase-activating polypeptides, Regul. Pept. 40, 29.
9. Jin, J.G., S. Katsoulis, W.E. Schmidt and J.R. Grider, 1994, Inhibitory transmission in tenia coli mediated by distinct vasoactive intestinal peptide and apamin-sensitive pituitary adenylate cyclase activating peptide receptors, J. Pharmacol. Exp. Ther. 270, 433.
10. Karasawa, Y., Y. Furukawa, L. Ren, M. Takei, M. Murakami, M. Narita and S. Chiba, 1990, Cardiac responses to VIP and VIP-ergiccholinergic interaction in isolated dog heart preparations, Eur. J. Pharmacol. 187, 9.
11. Lutz, E.M., W.J. Sheward, K.M. West, J.A. Morrow and G. Fink, 1993, The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide, FEBS Lett. 334, 3.
12. Masuo, Y., Y. Matsumoto, F. Tokito, M. Tsuda and M. Fujino, 1993, Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis, Brain Res. 611, 207.
13. Miyata, A., A. Arumura, R.R. Dahl, N. Minamino, A. Uehara, L. Jiang, M.D. Celler and D.H. Coy, 1989, Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells, Biochem. Biophys. Res. Commun. 164, 567.
14. Miyata, A., L. Jiang, R.D. Dahl, C. Kitada, K. Kubo, M. Fujino, M. Minamino and A. Arimura, 1990, Isolation of neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38), Biochem. Biophys. Res. Commun. 170, 643.
15. Potter, E.K., 1985, Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: neuromodulation by neuropeptide Y, Neurosci. Lett. 54, 117.
16. Ren, L.-M., Y. Furukawa, Y. Karasawa, M. Murakami, M. Takei, M. Narita and S. Chiba, 1991, Differential inhibition of neuropeptide Y on the chronotropic and inotropic responses to sympathetic and parasympathetic stimulation in the isolated, perfused dog atrium, J. Pharmacol. Exp. Ther. 259, 38.
17. Robberecht, P., P. Gourlet, P. De Neef, M.C. Woussen-Colle, M.C. Vandermeers-Piret, A. Vandermeers and J. Christophe, 1992, Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes, Eur. J. Biochem. 207, 239.
18. Robberecht, P., M.C. Woussen-Colle, P. Vertongen, P. De Neef, X. Hou, I. Salmon and J. Brotchi, 1994, Expression of pituitary adenylate cyclase activating polypeptide (PACAP) receptors in human glial cell tumors, Peptides 15, 661.
19. Sawangjaroen, K., C.R. Dallemagne, R.B. Cross and J.D. Curlewis, 1992, Effects of pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) on the cardiovascular system in sheep, Peptides 13, 1029.
20. Shivers, B.D., T.J. Gorcs, P.E. Gottschall and A. Arimura, 1991, Two high affinty binding sites for pituitary adenylate cyclase-activating polypeptide have different tissue distributions. Endocrinology 128, 3055.
21. Spengler, D., C. Waeber, C. Pantaloni, F. Holsboer, J. Bockaert, P.H. Seeburg and L. Journot, 1993, Differential signal transduction by five splice variants of the PACAP receptor, Nature 365, 170.
22. Sreedharan, S.P., J.X. Hung, M.C. Cheung and E.J. Goetzl, 1995, Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene, Proc. Natl. Acad. Sci. USA 92, 2939.
23. Suzuki, Y., K. Kasai, K. Takekosi, M. Oka, N. Banba, T. Numao, H. Sugimura, M. Iizuka and S. Shimoda, 1993, Effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the cardiovascular system, Regul. Pept. 47, 213.
24. Usdin, T.B., T.I. Bonner and E. Mezey, 1994, Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions, Endocrinology 135, 2662.
25. Warner, M.R. and M.N. Levy, 1989, Inhibition of cardiac vagal effects by neurally released and exogenous neuropeptide Y, Circ. Res. 65, 1536.
26. Warren, J.B., L.E. Donnelly, S. Cullen, B.E. Robertson, M.A. Ghatei, S.R. Bloom and J. MacDermot, 1991, Pituitary adenylate cyclase-activating polypeptide: a novel, long-lasting, endothelium-independent vasorelaxant, Eur. J. Pharmacol. 197, 131.
27. Watanabe, T., T. Ohtaki, C. Kitada, M. Tsuda and M. Fujino, 1990, Adrenal Pheochromocytoma PC12h cells respond to pituitary adenylate cyclase activating polypeptide, Biochem. Biophys. Res. Commun. 173, 252.
28. Yuwiler, A., G.L. Brammer and B.L. Bennett, 1995, Interaction between adrenergic and peptide stimulation in the rat pineal: pituitary adenylate cyclase-activating peptide, J. Neurochem. 64, 2273.