A novel monospecific IgG2/λ-autoantibody with specificity for a mitochondrial antigen: Evidence for an antigen-driven pathogenetic B-cell response in rheumatoid synovial tissue, induced by tissue alteration

Laboratory Investigation

Volumn 78, Issue 4, 1998, Pages 485-496

  Krenn, Veit ^a   Molitoris, Robin ^a   Berek, Claudia ^b   Sack, Ulrich ^c   König, Achim ^a   Müller Deubert, Sigrid ^a   Kempf, Volkhard ^a   Mosgoeller, Wilhelm ^d   Kerkau, Thomas ^a   Vollmers, H Peter ^a   Müller Hermelink, Hans Konrad ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CRYOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G2; RHEUMATOID FACTOR;

ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CARTILAGE CELL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; HYBRIDOMA; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM; TISSUE INJURY;

EID: 0031978289     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Alarcon-Segovia D, Ruiz-Argüelles A, and Llorente L (1995). Broken dogma: Penetration of autoantibodies into living cells. Immunol Today 17:163-164.
2. Arnett F, Edworthy S, Bloch D, McShane D, Fries J, Cooper N, Healy L, Kaplan S, Liang M, and Luthra H (1988). The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324.
3. Baccala R, Vo Quang T, Gilbert M, Ternynck T, and Avrameas S (1989). Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes. Proc Natl Acad Sci USA 86:4624-4628.
4. Berg P, Weber J, Oehring J, Lindenborn-Fotinos J, and Stechmesser E (1985). Significance of different types of mitochondrial antibodies in primary biliary cirrhosis. In: Brunner H and Thaler H, editors: Hepatology: A festschrift for Hans Popper. New York: Raven Press.
5. Berek C and Milstein C (1987). Mutation drift and repertoire shift in the maturation of immune response. Immunol Rev 96:23-41.
6. Borretzen M, Randen I, Natvig J, and Thompson KM (1995). Structural restriction in the heavy chain CDR3 of human rheumatoid factors. J Immunol 155:3630-3637.
7. Borretzen M, Chapman C, Natvig JB, and Thompson KM (1997). Differences in mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germ-line gene usage. Eur J Immunol 27:735-741.
8. Brown CM, Plater-Zyberg C, Mageed JB, Jeffris R, and Maini RN (1990). Analysis of immunoglobulins secreted by hybridomas derived from rheumatoid synovia. Clin Exp Immunol 80:366-372.
9. Burastero SE, Cutolo M, Dessi V, and Celada F (1990). Monoreactive and polyreactive rheumatoid factors produced by in vitro EBV transformed peripheral blood and synovial B-lymphocytes from rheumatoid patients. Scand J Immunol 32:347-357.
10. Ermel RW, Kenny TP, Wong A, Solomon A, Chen PP, and Robbins DL (1994). Preferential utilization of a novel Vλ3 gene in monoclonal rheumatoid factors derived from the synovial cells of rheumatoid arthritis patients. Arthritis Rheum 37:860-868.
11. Ezaki I, Kanda H, Sakai K, Fukui N, Shingu M, Nobunaga M, and Watanabe T (1991). Restricted diversity of the variable region nucleotide sequences of the heavy and light chains of a human rheumatoid factor. Arthritis Rheum 34:343-341.
12. L gene usage by anti-β-amyloid autoantibodies in Alzheimer's disease: Detection of highly mutated V regions in both heavy and light chains. Immunol Immunopathol 2:159-167.
13. Firestein GS, Yeo M, and Zvaifler NJ (1995). Apoptosis in rheumatoid arthritis synovium. J Clin Invest 96:1631-1638.
14. Gleeson PA and Ton BH (1991). Molecular targets in pernicious anaemia. Immunol Today 12:233-238.
15. Grey H and Kohler P (1973). Cryoimmunoglobulins. Semin Hematol 10:87-112.
16. + B cells from a rheumatoid arthritis patient. Int Immunol 3:865-875.
17. Holmdahl R, Vingsbo C, Mo JA, Michaelsson E, Malmström V, Jansson L, and Brunsberg U (1995). Chronicity of tissue-specific experimental autoimmune disease: A role for B cells? Immunol Rev 144:109-135.
18. K segment structure of anti-insulin autoantibodies in patients with insulin-dependent diabetes mellitus. J Immunol 152:1430-1441.
19. James K and Bell GT (1987). Human monoclonal antibody production. Current status and future prospects. J Immunol Methods 100:5-40.
20. Krenn V, von Landenberg P, Wozniak E, Kissler C, Müller-Hermelink HK, Zimmermann U, and Vollmers HP (1995). Efficient immortalization of rheumatoid synovial tissue B-lymphocytes. A comparison between the techniques of electric field-induced and PEG fusion. Hum Antibodies Hybridomas 6:47-51.
21. Krenn V, Schalhorn N, Greiner A, Molitoris R, König A, Gohlke F, and Müller-Hermelink HK (1996a). Immunohistochemical analysis of proliferating and antigen-presenting cells in rheumatoid synovial tissue. Rheumatol Int 15:239-247.
22. Krenn V, Vollmers HP, von Landenberg P, Schmausser B, Rupp M, Roggenkamp A, and Müller-Hermelink HK (1996b). Immortalized B-lymphocytes from rheumatoid synovial tissue show specificity for bacterial HSP 60. Virchows Arch 427: 511-518.
23. Lu EW, Deftos M, Olee T, Huang D, Soto-Gil R, Carson D, and Chen P (1993). Generation and molecular analyses of two rheumatoid synovial fluid-derived IgG rheumatoid factors. Arthritis Rheum 36:927-937.
24. Manns M (1994). Relevance of cytoplasmic autoantigens in autoimmune hepatitis. In: Nishoka M, Toda G, and Zeniya M, editors: Autoimmune hepatitis, Amsterdam: Elsevier, 165-175.
25. Markert T, Krenn V, Leebmann J, and Walter U (1996). High expression of the focal adhesion- and microfilament-associated protein VASP in vascular smooth muscle and endothelial cells of the intact human vessel wall. Basic Res Cardiol 91:337-343.
26. Marks J, Hoogenboom H, Bonnert T, McCaffertty J, Griffiths A, and Winter G (1991). By-passing immunization. J Mol Biol 222:581-597.
27. Mosgoeller W, Steiner M, Hopzak P, Penner E, and Wesierska-Gadek J (1996). Nuclear architecture and ultra-structural distribution of poly (ADP-ribosyl)transferase, a multifunctional enzyme. J Cell Sci 109:409-418.
28. Musset L, Duarte F, Gaillard O, Du T, Biala J, Galli J, and Preud'homme J (1994). Immunochemical characterization of monoclonal IgG containing mixed cyroglobulins. Clin Immunol Immunpathol 70:166-170.
29. Naiki M, Robbins DL, Kenny T, Yago H, Suehiro S, Gershwin ME, and Konishi J (1992). Characterization of monoclonal IgG antibodies produced by hybridomas derived from rheumatoid synovial cells. Hum Antibodies Hybridomas 3:60-64.
30. Nakajima T, Aono H, Hasunuma T, Yamamoto K, Shirai T, Hirohata K, and Nishioka K (1995). Apoptosis and functional fas-antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum 38:485-491.
31. Olee T, Lu EW, Huang DF, Soto-Gil RW, Deftos M, Kozin F, Carson DA, and Chen PP (1992). Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response. J Exp Med 175:831-842.
32. Paul WE (1993). Fundamental immunology. 3rd ed. New York: Raven Press, 917-939.
33. Pfaff M, O'Connor R, Vollmers HP, and Müller-Hermelink HK (1990). Human monoclonal antibody against a tissue polypeptide antigen related protein from a patient with a signet-ring cell carcinoma of the stomach. Cancer Res 50: 5192-5198.
34. Randen I, Mellbye OJ, Forre O, and Natvig JB (1995). The identification of germinal centers and follicular dendritic cell networks in rheumatoid synovial tissue. Scand J Immunol 41:481-486.
35. Randen I, Thompson KM, Natvig JB, Forre O, and Waalen K (1989). Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: production and characterization. Clin Exp Immunol 78:13-18.
36. Reichlin M (1995). Short analytical review: Cell injury mediated by autoantibodies to intracellular antigens. Clin Immunol Immunopathol 76:215-219.
37. Robbins DL, Kenny TP, Coloma MJ, Gavilondo-Cowley JV, Soto-Gil RW, Chen PP, and Larrick JW (1990). Serologic and molecular characterization of a human monoclonal rheumatoid factor derived from rheumatoid synovial cells. Arthritis Rheum 33:1188-1195.
38. Rowley MJ, Williamson DJ, and Mackay IR (1987). Evidence for local synthesis of antibodies to denatured collagen in the synovium in rheumatoid arthritis. Arthritis Rheum 30:1420-1425.
39. Sack U, Kuhn H, Ermann J, Kinne RW, Vogt S, Jungmichel D, and Emmrich F (1994). Synovial tissue implants from patients with rheumatoid arthritis cause cartilage destruction in knee joints of SCID.bg mice. J Rheumatol 21:10-16.
40. Schnaitmann C and Greenawalt J (1968). Enzymatic properties of the inner and outer membranes of the rat liver mitochondria. J Cell Biol 38:158-175.
41. Schröder AE, Greiner A, Seyfert C, and Berek C (1996). Differentiation of B cells in the non lymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci USA 93:221-225.
42. Shmeling R and Delbanco T (1991). The rheumatoid factor: An analysis of clinical utility. Am J Med 91:528-534.
43. Shoenfeld Y (1994). Idiotypic induction of autoimmunity: A new aspect of the idiotypic network. FASEB J 8:1296-1301.
44. Sternberg S (1994). Diagnostic surgical pathology, 2nd ed. New York: Raven Press, 235-236.
45. Storrie B and Madden A (1990). Isolation of subcellular organelles. Methods Enzymol 182:203-209.
46. Tarkowski A, Czerkinsky C, and Nilsson LA (1985). Simultaneous induction of rheumatoid factor- and antigen-specific antibody-secreting cells during the secondary immune response in man. Clin Exp Immunol 61:379-387.
47. Thompson KM, Randen I, Borretzen M, Forre O, and Natvig JB (1994). Variable region gene usage of human monoclonal rheumatoid factors derived from healthy donors following immunization. Eur J Immunol 24:1771-1778.
48. Voswinkel, Trümper L, Carbon G, Hopf T, Pfreundschuh M, and Gause A (1996). Evidence for a selected humoral immune response encoded by VH4 family genes in the synovial membrane of a patient with rheumatoid arthritis (RA). Exp Immunol 106:5-12.
49. Wesierska G, Penner E, Hitchman E, Kier P, and Sauermann G (1992). Nucleolar proteins B23 and C23 as target antigens in chronic graft-versus-host disease Blood 79:1081-1086.
50. Welch MJ, Fong S, Vaughan J, and Carson D (1983). Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid. Clin Exp Immunol 51:299-304.
51. Zhang C, Ao Z, Seth A, and Schlossman SF (1996). A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells. J Immunol 157:3980-3987.