Novel functions of interferon-induced proteins

Seminars in Cancer Biology

Volumn 10, Issue 2, 2000, Pages 93-101

  Sen, Ganes C ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

2 5(A) synthetase; IFN induced proteins; P200; P56; PKR

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; INTERFERON; NUCLEAR PROTEIN; PROTEIN KINASE; PROTEIN P200; PROTEIN P56; RNA; UNCLASSIFIED DRUG;

APOPTOSIS; BIOCHEMISTRY; DIFFERENTIATION; GENETIC REGULATION; GENETIC TRANSDUCTION; GROWTH; NONHUMAN; PROTEIN INDUCTION; PROTEIN METABOLISM; REVIEW;

EID: 0033909789     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2000.0312     Document Type: Article

References (44)

1. Der S D, Zhou A, Williams B R, Silverman R H. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci USA. 95:1998;15623-15628.
2. Stark G R, Kerr I M, Williams B R, Silverman R H, Schreiber R D. How cells respond to interferons. Annu Rev Biochem. 67:1998;227-264.
3. Biron C, Sen G C. Interferons, chemokines and other cytokines. Knipe D, Howley P, Griffin D, Lamb R, Martin M, Straus S. Fields Virology. 2000;Lippincott, Williams and Wilkins, Philadelphia.
4. Rebouillat D, Hovanessian A G. The human 2',5'-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties. J Interferon Cytokine Res. 19:1999;1917-1924.
5. Silverman R H, Cirino N M. mRNA metabolism and post-transcriptional gene regulation. Morris D R, Hartford J B. Gene Regulation. 1997;295-309 John Wiley & Sons, New York.
6. Ghosh A, Sarkar S, Sen G. Cell growth regulatory and anti-viral effects of the P69 isozyme of 2-5 (A) synthetase. Virology. 266:2000;319-328.
7. Ghosh S K, Kusari J, Bandyopadhyay S K, Samanta H, Kumar R, Sen G C. Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships. J Biol Chem. 266:1991;15293-15299.
8. Sarkar S N, Bandyopadhyay S, Ghosh A, Sen G C. Enzymatic characteristics of recombinant medium isozyme of 2'-5'-oligoadenylate synthetase. J Biol Chem. 274:1999;1848-1855.
9. Sarkar S N, Sen G C. Production, purification, and characterization of recombinant 2',5'-oligoadenylate synthetases. Methods. 15:1998;233-242.
10. Ghosh A, Desai S Y, Sarkar S N, Ramaraj P, Ghosh S K, Bandyopadhyay S, Sen G C. Effects of mutating specific residues present near the amino terminus of 2'-5'-oligoadenylate synthetase. J Biol Chem. 272:1997;15452-15458.
11. Bandyopadhyay S, Ghosh A, Sarkar S N, Sen G C. Production and purification of recombinant 2'-5'-oligoadenylate synthetase and its mutants using the baculovirus system. Biochemistry. 37:1998;3824-3830.
12. Ghosh A, Sarkar S N, Guo W, Bandyopadhyay S, Sen G C. Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein. J Biol Chem. 272:1997;33220-33226.
13. Sarkar S N, Ghosh A, Wang H W, Sung S S, Sen G C. The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases. J Biol Chem. 274:1999;25535-25542.
14. Ghosh A, Sarkar S, Sen G. A new isozyme-specific cellular effect of 2-5 (A) synthetase. J Interferon Cytokine Res. 19:1999;S68.
15. Clemens M J, Elia A. The double-stranded RNA-dependent protein kinase PKR: structure and function. J Interferon Cytokine Res. 17:1997;503-524.
16. Tan S L, Katze M G. The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death? J Interferon Cytokine Res. 19:1999;543-554.
17. Williams B R. PKR, a sentinel kinase for cellular stress. Oncogene. 18:1999;6112-6120.
18. Patel R C, Stanton P, McMillan N M, Williams B R, Sen G C. The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo. Proc Natl Acad Sci USA. 92:1995;8283-8287.
19. Patel R C, Sen G C. Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast. Mol Cell Biol. 18:1998;7009-7019.
20. Patel R C, Stanton P, Sen G C. Role of the amino-terminal residues of the interferon-induced protein kinase in its activation by double-stranded RNA and heparin. J Biol Chem. 269:1994;18593-18598.
21. Patel R C, Sen G C. PACT, a protein activator of the interferon-induced protein kinase, PKR. EMBO J. 17:1998;4379-4390.
22. Ito T, Yang M, May W S. RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. J Biol Chem. 274:1999;15427-15432.
23. Patel R C, Vestal D J, Xu Z, Bandyopadhyay S, Guo W, Erme S M, Williams B R, Sen G C. DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR. J Biol Chem. 274:1999;20432-20437.
24. Balachandran S, Kim C N, Yeh W C, Mak T W, Bhalla K, Barber G N. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J. 17:1998;6888-6902.
25. Kusari J, Szabo P, Grzeschik K H, Sen G C. Chromosomal localization of the interferon-inducible human gene encoding mRNA 561. J Interferon Res. 7:1987;53-59.
26. Lafage M, Clauss I, Couez D, Simonetti J, Wathelet M G, Huez G. The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosoms 10 at bands q23-q24. Genomics. 13:1992;458-460.
27. Chebath J, Merlin G, Metz R, Benech P, Revel M. Interferon-induced 56 000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA. Nucleic Acids Res. 11:1983;1213-1226.
28. Kusari J, Sen G C. Regulation of synthesis and turnover of an interferon-inducible mRNA. Mol Cell Biol. 6:1986;2062-2067.
29. Wathelet M G, Clauss I M, Content J, Huez G A. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. FEBS Lett. 231:1988;164-171.
30. Tiwari R K, Kusari J, Sen G C. Functional equivalents of interferon-mediated signals needed for induction of an mRNA can be generated by double-stranded RNA and growth factors. EMBO J. 6:1987;3373-3378.
31. Guo J, Peters K, Sen G C. Induction of the human protein P56 by interferon, double-stranded RNA or virus infection. Virology. 267:2000;209-219.
32. Guo J, Sen G C. Characterization of the interaction between the interferon-induced protein P56 and the Int-6 protein encoded by a locus of insertion of the mouse mammary tumor virus. J Virol. 74:2000;1892-1899.
33. Asano K, Merrick W C, Hershey J W. The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome. J Biol Chem. 272:1997;23477-23480.
34. Guo J, Sen G C. The interferon-induced protein, P56, binds to the P48 subunit of the translation initiation factor eiF-3 and inhibits translation. Eur Cytokine Network. 9:1998;325.
35. Lengyel P, Choubey D, Li S, Datta B. The interferon-activatable gene 200 cluster: from structure toward function. Sem Virol. 6:1995;202-213.
36. Wang H, Chatterjee G, Meyer J J, Liu C J, Manjunath N A, Bray-Ward P, Lengyel P. Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster. Genomics. 60:1999;281-294.
37. Choubey D, Lengyel P. Binding of an interferon-inducible protein (p202) to the retinoblastoma protein. J Biol Chem. 270:1995;6134-6140.
38. Choubey D, Li S J, Datta B, Gutterman J U, Lengyel P. Inhibition of E2F-mediated transcription by p202. EMBO J. 15:1996;5668-5678.
39. Min W, Ghosh S, Lengyel P. The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities. Mol Cell Biol. 16:1996;359-368.
40. Datta B, Li B, Choubey D, Nallur G, Lengyel P. p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. J Biol Chem. 271:1996;27544-27555.
41. Datta B, Min W, Burma S, Lengyel P. Increase in p202 expression during skeletal muscle differentiation: inhibition of MyoD protein expression and activity by p202. Mol Cell Biol. 18:1998;1074-1083.
42. Liu C J, Wang H, Lengyel P. The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription. EMBO J. 18:1999;2845-2854.
43. Hertel L, De Andrea M, Azzimonti B, Rolle A, Gariglio M, Landolfo S. The interferon-inducible 204 gene, a member of the Ifi 200 family, is not involved in the antiviral state induction by IFN-alpha, but is required by the mouse cytomegalovirus for its replication. Virology. 262:1999;1-8.
44. Xie J, Briggs J A, Briggs R C. Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding. J Cell Biochem. 70:1998;489-506.