Altered G1 phase regulation in osteosarcoma

International Journal of Cancer

Volumn 74, Issue 5, 1997, Pages 518-522

  Benassi, M Serena ^a,b   Molendini, Lara ^a   Gamberi, Gabriella ^a   Sollazzo, M Rosa ^a   Ragazzini, Paola ^a   Merli, Mara ^a   Magagnoli, Giovanna ^a   Sangiorgi, Luca ^a   Bacchini, Patrizia ^a   Bertoni, Franco ^a   Picci, Piero ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b Laboratory of Oncologic Research   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; RETINOBLASTOMA PROTEIN; CDK4 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE 4; ONCOPROTEIN;

ARTICLE; CANCER RECURRENCE; CELL CYCLE G1 PHASE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; BONE TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; SERODIAGNOSIS;

BONE NEOPLASMS; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; G1 PHASE; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; OSTEOSARCOMA; PRECIPITIN TESTS; PROGNOSIS; PROTO-ONCOGENE PROTEINS; RETINOBLASTOMA PROTEIN;

EID: 0030611932     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19971021)74:5<518::AID-IJC7>3.0.CO;2-6     Document Type: Article

References (22)

1. BUCHKOVICH, K., DUFFY, L.A. and HARLOW, E., The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell, 58, 1097-1105 (1989).
2. DOWDY, S.F., HINDS, P.W., LOUIE, K., REED, S.I., ARNOLD, A. and WEINBERG, R.A., Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73, 499-511 (1993).
3. EWEN, M.E., SLUSS, H.K., SHERR, C.J., KATO, J., LIVINGSTON, D.M. and MATSUSHIME, H., Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell, 73, 487-497 (1993).
4. FEUGEAS, O. and 12 OTHERS, Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. J. clin. Oncol., 14, 467-472 (1996).
5. HALL, M., BATES, S. and PETERS, G., Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene 11, 1581-1588 (1993).
6. JUNG, W., ZHANG, Y.-J., KAHN, S.M., HOLLSTEIN, M.C., SANTELLA, R.M., LU, S.-H., HARRIS, C.C., MONTESANO, R. and WEINSTEIN, I.B., Altered expression of cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc. nat. Acad. Sci. (Wash.), 90, 9026-9030 (1993).
7. KARPEH, M.S., BRENNAN, M.F., CANCE, W.G., WOODRUFF, J.M., POLLACK, D., CASPER, E.S., DUDAS, M.E., LATRES, E., DROBNJAK, M. and CORDON-CARDO, C., Altered patterns of retinoblastoma gene product expression in adult soft-tissue sarcomas. Brit. J. Cancer, 72, 986-991 (1995).
8. KATO, J.Y., MATSUSHIME, H., HIEBERT, S.W., EWEN, M.E. and SHERR, C.J., Direct binding of cyclin-D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase, CDK4. Genes Develop., 7, 331-342 (1993).
9. KHATIB, Z.A., MATUSHIME, H., VALENTINE, M., SHAPIRO, D.N., SHERR, C.J. and LOOK, A.T., Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res., 53, 5535-5541 (1993).
10. LOVEC, H., SEWING, A., LUCIBELLO, F.C., MULLER, R. and MOROY, T., Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation. Oncogene, 9, 323-326 (1994).
11. 1 control in retinoblastoma gene-deficient cells independently of CDK4 activity. Mol. cell. Biol., 15, 2600-2611 (1995).
12. McINTOSH, G.G., ANDERSON, J.J., MILTON, I., STEWARD, M., PARR, A.H., THOMAS, M.D., HENRY, J.A., ANGUS, B., LENNARD, T.W.J. and HORN, C.H.W., Determination of the prognostic value of cyclin D1 overexpression in breast cancer. Oncogene, 11, 885-891 (1995).
13. MULLER, H., LUKAS, J., SCHNEIDER, A., WARTHOE, P., BARTEK, J., EILERS, M. and STRAUSS, M., Cyclin D1 expression is regulated by the retinoblastoma protein. Proc. nat. Acad. Sci. (Wash.), 91, 2945-2949 (1994).
14. NEVINS, J.R., E2F: a link between the RB tumor suppressor protein and viral oncoproteins. Science, 258, 424-429 (1992).
15. REIFENBERGER, G., REIFENBERGER, J., ICHIMURA, K., MELTZER, P.S. and COLLINS, V.P., Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res., 54, 4299-4303 (1994).
16. SCHOLZ, R.B., BIOL, D., KABISCH, H., WEBER, B., ROSER, K., DELLING, G. and WINKLER, K., Studies of the RB1 gene and p53 gene in human osteosarcoma. Pediatr. Hematol. Oncol., 9, 125-137 (1992).
17. 1 cyclins. Cell 73, 1059-1065 (1993).
18. 1 progression. Oncogene, 9, 2663-2674 (1994).
19. TOGUCHIDA, J., ISHIZAKI, K., SASAKI, M.S., IKENAGA, M., SUGIMGTO, M., KOTOURA, Y. and YAMAMURO, T., Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma. Cancer Res., 48, 3939-3943 (1988).
20. WADAYAMA, B.-I., TOGUCHIDA, J., SHIMIZU, T., ISHIZAKI, K., SASAKI, M.S., KOTOURA, Y. and YAMAMURO, T., Mutation spectrum of the retinoblastoma gene in osteosarcoma. Cancer Res., 54, 3042-3048 (1994).
21. WEINBERG, R.A., Oncogene, antioncogenes, and the molecular bases of multistep carcinogenesis. Cancer Res., 49, 3713-3721 (1989).
22. XIONG, Y., ZHANG, H. and BEACH, D., Cellular transformation is associated with selective disruption and subunit rearrangement of cyclin/CDK complexes. Genes Develop., 7, 1572-1583 (1993).