Transcriptional activation of scavenger receptor expression in human smooth muscle cells requires AP-1/c-Jun and C/EBPβ: Both AP-1 binding and JNK activation are induced by phorbol esters and oxidative stress

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 9, 1998, Pages 1440-1449

  Mietus Snyder, Michele ^a,b   Glass, Christopher K ^c   Pitas, Robert E ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

Activating protein 1; c Jun activating kinase; Oxidative stress; Phorbol ester; Scavenger receptor

Indexed keywords

PHORBOL ESTER; SCAVENGER RECEPTOR;

ARTICLE; CELL MIGRATION; DRUG RECEPTOR BINDING; ENHANCER REGION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE INDUCTION; HUMAN; HUMAN CELL; ONCOGENE C JUN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR GENE; SMOOTH MUSCLE FIBER; TRANSCRIPTION REGULATION;

EID: 0031694639     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.9.1440     Document Type: Article

References (15)

1. Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M. Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils. Nature. 1990;343:531-535.
2. Rohrer L, Freeman M, Kodama T, Penman M, Krieger M. Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Nature. 1990;343:570-572.
3. Krieger M, Herz J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem. 1994;63:601-637.
4. Fogelman AM, Haberland ME, Seager J, Hokom M, Edwards PA. Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages. J Lipid Res. 1981;22:1131-1141.
5. Imamura K, Dianoux A, Nakamura T, Kufe D. Colony-stimulating factor 1 activates protein kinase C in human monocytes. EMBO J. 1990;9:2423-2429.
6. Moulton KS, Semple K, Wu H, Glass CK. Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif. Mol Cell Biol. 1994;14:4408-4418.
7. Pitas RE. Expression of the acetyl low density lipoprotein receptor by rabbit fibroblasts and smooth muscle cells: up-regulation by phorbol esters. J Biol Chem. 1990;265:12722-12727.
8. Bickel PE, Freeman MW. Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells. J Clin Invest. 1992;90:1450-1457.
9. Pitas RE, Friera A, McGuire J, Dejager S. Further characterization of the acetyl LDL (scavenger) receptor expressed by rabbit smooth muscle cells and fibroblasts. Arterioscler Thromb. 1992;12:1235-1244.
10. Dejager S, Mietus-Snyder M, Pitas RE. Oxidized low density lipoproteins bind to the scavenger receptor expressed by rabbit smooth muscle cells and macrophages. Arterioscler Thromb. 1993;13:371-378.
11. Inaba T, Gotoda T, Shimano H, Shimada M, Harada K, Kozaki K, Watanabe Y, Hoh E, Motoyoshi K, Yazaki Y, Yamada N. Platelet-derived growth factor induces c-fms and scavenger receptor genes in vascular smooth muscle cells. J Biol Chem. 1992;267:13107-13112.
12. Gong Q, Pitas RE. Synergistic effects of growth factors on the regulation of smooth muscle cell scavenger receptor activity. J Biol Chem. 1995;270:21672-21678.
13. Li H, Freeman MW, Libby P. Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines. J Clin Invest. 1995;95:122-133.
14. Mietus-Snyder M, Friera A, Glass CK, Pitas RE. Regulation of scavenger receptor expression in smooth muscle cells by protein kinase C: a role for oxidative stress. Arterioscler Thromb Vasc Biol. 1997;17:969-978.
15. 2 and vanadate stimulate protein tyrosine phosphorylation in intact cells. J Biol Chem. 1990;265:2896-2902.