Protein-targeting determinants in the secretory pathway of apicomplexan parasites

Current Opinion in Microbiology

Volumn 3, Issue 4, 2000, Pages 422-428

  Kaasch, Achim J ^a   Joiner, Keith A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; APICOMPLEXA; CELL GRANULE; CELL ORGANELLE; CELL VACUOLE; ENDOPLASMIC RETICULUM; EVOLUTION; GOLGI COMPLEX; HOST PARASITE INTERACTION; INTRACELLULAR TRANSPORT; NONHUMAN; PARASITOSIS; PROTEIN SECRETION; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW; TOXOPLASMA;

EID: 0033875587     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(00)00115-6     Document Type: Review

References (47)

1. Progress in taxonomy of the Apicomplexan protozoa
2. Important parasites in poultry production systems
3. A review of the importance of cryptosporidiosis in farm animals
4. Neosporosis in cattle: Biology and economic impact
5. World malaria situation in 1994 Part I. Population at risk
6. Toxoplasmosis
7. Toxoplasma gondii: Fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts
8. Toxoplasma gondii resides in a vacuole that avoids fusion with host cell endocytic and exocytic vesicular trafficking pathways
9. The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: An unusual compartrnent in infected cells
10. Kinetics and pattern of organelle exocytosis during Toxoplasma gondii/host-cell interaction
11. Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts
12. Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite
13. Secretion of micronemal proteins is associated with Toxoplama invasion of host cells
14. Gliding motility: An efficient mechanism for cell penetration
15. Conservation of a gliding motility and cell invasion machinery in Apicomplexan parasites
16. Characterization of the lipid content of Toxoplasma gondii rhoptries
17. Toxoplasma gondii exploits host LDL-receptor-mediated endocytosis for cholesterol acquisition
18. Intracellular trafficking of dense granule proteins in Toxoplasma gondii and experimental evidences for a regulated exocytosis
19. Constitutive calcium-independent release of Toxoplasma gondii dense granules occurs through the NSF/SNAP/SNARE/Rab machinery
20. Regulated secretion of multi-lamellar vesicles leads to formation of a tubulo-vesicular network in host-cell vacuoles occupied by Toxoplasma gondii
21. Differential membrane targeting of the secretory proteins GRA4 and GRA6 within the parasitophorous vacuole formed by Toxoplasma gondii
22. Brefeldin A: The advantage of being uncompetitive
23. Processing of Toxoplasma ROP1 protein in nascent rhoptries
24. The protozoan parasite Toxoplasma gondii targets proteins to dense granules and the vacuolar space using both conserved and unusual mechanisms
25. The nuclear envelope serves as an intermediary between the ER and Golgi complex in the intracellular parasite Toxoplasma gondii
26. Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the Apicomplexa
27. Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum
28. An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum
29. A tyrosine-containing motif mediates ER retention of CD3-epsilon and adopts a helix-turn structure
30. New COP1-binding motifs involved in ER retrieval
31. Targeting to the endoplasmic reticulum in yeast cells by determinants present in transmembrane domains
32. Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum
33. Cytoplasmic tail motifs mediate ER localization and export of transmembrarte reporters in the protozoan parasite Toxoplasma gondii
34. A di-acidic (DXE) code directs concentration of cargo during export from the endoplasmic reticulum
35. The current status of the glycobiology of Toxoplasma gondii: Glycosylphosphatidylinositols, N- and O-linked glycans
36. The dense granule antigen, GRA2 of Toxoplasma gondii is a glycoprotein containing O-linked oligosaccharides
37. Differential sorting and post secretory targeting of proteins in parasitic invasion
38. Molecular bases for the recognition of tyrosine-based sorting signals
39. Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells
40. Expression, selection, and organellar targeting of the green fluorescent protein in Toxoplasma gondii
41. A transmembrane form of the prion protein in neurodegenerative disease
42. Acidic compartments and rhoptry formation in Toxoplasma gondii
43. Biogenesis of rhoptry organelles in Plasmodium falciparum
44. Targeting of rhoptry organelles of Toxoplasma gondii involves evolutionary conserved protein sorting mechanisms
45. The amphipathic alpha helices of the Toxoplasma protein GRA2 mediate post-secretory membrane association
46. A soluble secretory protein of the intracellular parasite Toxoplasma gondii associates with the parasitophorous vacuole membrane through hydrophobic interactions
47. Transmembrane insertion of the Toxoplasma gondii GRA5 protein occurs after soluble secretion into the host cell