CD44v10 in hematopoiesis and stem cell mobilization

Leukemia and Lymphoma

Volumn 38, Issue 5-6, 2000, Pages 463-480

  Zoeller, M ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

CD44v10; Hematopoietic progenitors; Mobilization; Mouse

Indexed keywords

BETA1 INTEGRIN; CD34 ANTIGEN; CD44V ANTIGEN; CELL ADHESION MOLECULE; GRANULOCYTE COLONY STIMULATING FACTOR; MONOCLONAL ANTIBODY; RECEPTOR;

ANTIGEN EXPRESSION; BLOOD; BONE MARROW CELL; CANCER; CELL LINEAGE; CELL MATURATION; CELL MOTION; COLONY FORMING UNIT; HEMATOPOIESIS; HUMAN; MOUSE; NONHUMAN; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; REVIEW; SPLEEN; STEM CELL; STEM CELL TRANSPLANTATION; STROMA;

EID: 0033868751     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428190009059265     Document Type: Review

References (183)

1. To, L.B., Haylock, D.N., Simmons, P.J. and Juttner, C.A. (1997) The biology and clinical uses of blood stem cells. Blood, 89, 2233-2258.
2. Ross, A.A. (1998) Minimal residual disease in solid tumor malignancies: a review. J Hematother, 1, 9-18.
3. Richman, C.M., Schuermann, T.C., Wun, T., Malik, R., O'Donnell, R.T., DeNardo, G.L. and DeNardo S.J. (1997) Peripheral blood stem cell mobilization for hematopoietic support of radioimmunotherapy in patients with breast carcinoma. Cancer 80 (12 Suppl), 2728-2732.
4. Byrne, J.L., Haynes, A.P. and Russell, N.H. (1997) Use of haematopoietic growth factors: commentary on the ASCO/ECOG guidelines. Blood Rev, 11, 16-27.
5. Dasgupta, A., Willeford, D.M. and McAfee, S.L. (1996) Methods in stem cell mobilization. J Infus Chemother, 6, 12-16.
6. Rondelli, D., Raspadori, D., Anasetti, C., Bandini, G., Re, F., Arpinati, M., Stanzani, M., Morelli, A., Baccini, C., Zaccaria, A., Lemoli, R.M. and Tura, S. (1998) Alloantigen presenting capacity, T cell alloreactivity and NK function of G-CSF-mobilized peripheral blood cells. Bone Marrow Transplant, 22, 631-637.
7. Demirer, T., Bensinger, W.I. and Buckner, C.D. (1999) Peripheral blood stem cell mobilization for high-dose chemotherapy. J Hemtother, 8, 103-113.
8. Shpall, E.J. (1999) The utilization of cytokines in stem cell mobilization strategies. Bone Marrow Transplant 23 (Suppl 2); 13-19.
9. Lemoli, R.M., Tafuri, A., Fortuna, A., Catani, L., Rondelli, D., Ratta, M. and Tura, S. (1998) Biological characterization of CD34+ cells mobilized into peripheral blood. Bone Marrow Transplant, 22 (Suppl 5), 47-50.
10. Tanaka, J., Imamura, M., Kasai, M., Asaka, M. and Torok-Storb, B. (1999) The role of accessory cells in allogeneic peripheral blood stem cell transplantation. Int J Hematol, 69, 70-74.
11. Horwitz, M.E., Malech, H.L., Anderson, S.M., Girard, L.J., Bodline, D.M. and Orlic, D. (1999) Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA. Exp Hematol, 27, 1160-1167.
12. Vellenga, E., vanPutten, W.L., Boogaerts, M.A., Daenen, S.M., Verhoef, G.E., Hagenbeek, A., Jonkhoff, A.R., Huijgens, P.C., Verdonck, L.F., van derLelie, J., Schouten, H.C., Gmur, J., Wijermans, P., Gratwohl, A., Hess, U., Fey, M.F. and Lowenberg, B. (1999) Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia? Bone Marrow Transplant, 23, 1279-1282.
13. Theilgaard-Monch, K., Raaschou-Jensen, K., Andersen, H., Russell, C.A., Vindelov, L., Jacobsen, N. and Dickmeiss, E. (1999) Single leukapheresis products collected from healthy donors after the administration of granulocyte colony-stimulating factor contain ten-fold higher numbers of long-term reconstituting hematopoietic progenitor cells than conventional bone marrow allografts. Bone Marrow Transplant, 23, 243-249.
14. Tabbara, I.A., Ghazal, C.D. and Ghazal, H.H. (1997) The role of granulocyte colony-stimulating factor in hematopoietic stem cell transplantation. Cancer Invest, 15, 353-357.
15. Haas, R. and Murea, S. (1995) The role of granulocyte colony stimulating factor in mobilization and transplantation of peripheral blood progenitor and stem cells. Cytokines Mol Ther, 1, 249-270.
16. Cleaver, S.A. and Goldman, J.M. (1998) Use of G-CSF to mobilise PBSC in normal healthy donors - an international survey. Bone Marrow Transplant, 21 (Suppl 3), 29-31.
17. Goldman, J. (1995) Peripheral blood stem cells for allografting. Blood, 85, 1413-1415.
18. Mijovic, A., Pagliuca, A. and Mufti, G.J. (1999) The "G-CSF test": the response to a single dose of granulocyte colony-stimulating factor predicts mobilization of hemopoietic progenitors in patients with hematological malignancies. Exp Hematol, 27, 1204-1209.
19. Gazitt, Y., Freytes, C.O., Callander, N., Tsai, T.W., Alsina, M., Anderson, J., Holle, L., Cruz, J., Devore, P., Mcgrath, M., West, G., Alvarez, R. and Montgomery, W. (1999) Successful PBSC mobilization with high-dose G-CSF for patients failing a first round of mobilization. J Hematother, 8, 173-183.
20. Fruehauf, S., Schmitt, K., Veldwijk, M.R., Topaly, J., Benner, A., Zeller, W.J., Ho, A.D. and Haas, R. (1999) Peripheral blood progenitor cells (PBPC) counts during steady-state haemopoiesis enable the estimation of the yield of mobilized PBPC after granulocyte colony-stimulating factor supported cytotoxic chemotherapy: an update on 100 patients. Br J Haematol, 105, 786-794.
21. Divine, M., Boutolleau, D., Delfau-Larue, M.H., Beaujean, F., Jouault, H., Reyes, F., Kuentz, M., Benussan, A., Farcet, J.P. and Boumsell, L. (1999) Poor lymphocyte recovery following CD34-selected autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma. Brit J Haematol, 105, 349-360.
22. Martinet, C., Urbano-Ispizua, A., Rozman, M., Rovira, M., Marin, P., Montfort, N., Carreras, E. and Monserra, E. (1999) Effects of short term administration of G-CSF (Filgrastin) on bone marrow progenitor cells: analysis of serial marrow samples from normal donors. Bone Marrow Transplant, 23, 15-19.
23. Mohle, R., Haas, R. and Hunstein, W. (1993) Expression of adhesion molecules and c-kit on CD34+ hematopoietic progenitor cells: comparison of cytokine mobilized blood stem cells with normal bone marrow and peripheral blood. J Hematother, 2, 483-489.
24. Papayannopoulou, T. (1999) Hematopoietic stem/progenitor cell mobilization: A continuing quest tor etiologic mechanisms. Ann N Y Acad Sci. 872, 187-197.
25. Friedrich, C., Zausch, E., Sugrue, S.P. and Gutierrez-Ramos, J.C. (1996) Hematopoietic supportive functions of mouse bone marrow and fetal liver microenvironment: Dissection of granulocyte, B lymphocyte, and hematopoitic progenitor support at the stromal cell clone level. Blood, 87, 4596-4606.
26. Turner, M.L. and Sweetenham, J.W. (1996) Haematopoietic progenitor homing and mobilization. Br J Haematol, 94, 592-596.
27. Vermeulen, M., LePesteur, F., Gagnerault, M.C., May, J.Y., Sainteny, F. and Lepault, F. (1998) Role of adhesion molecules in the homing and mobilization of murine hematopoitic stem and progenitor cells. Blood, 92, 894-900.
28. Papayannopoulou, T. and Craddock, C. (1997) Homing and trafficking of hemopoietic progenitor cells. Acta Haematol, 97, 97-104.
29. Rösel, M., Khaldoyanidi, S., Zawadzki, V. and Zöller, M. (1999) Involvement of CD44 exon v10 in B cell maturation. Exp Hematol, 27, 698-711.
30. Coulombel, L., Auffray, I., Gaugler, M.H. and Rosemblatt, M. (1997) Expression and function of integrins on hematopoietic progenitor cells. Acta Haematol, 97, 13-21.
31. Anzai, N., Gotoh, A., Shibayama, H. and Broxmeyer, H.E. (1999) Modulation of integrin function in hematopoietic progenitor cells by CD43 engagement: possible involvement of protein tyrosine kinase and phospholipase C-gamma. Blood, 93, 3317-3326.
32. Kroger, N., Zeller, W., Hassan, H.A.T., Dierlamm, J. and Zander, A.R. (1998) Difference between expression of adhesion molecules on CD34+ cells from bone marrow and G-CSF-stimulated peripheral blood. Stem cells, 16, 49-53.
33. Dercksen, M.W., Gerritsen, W.R., Rodenhuis, S., Dirkson, M.K., Slaper-Cortenbach, I.C., Schaasberg, W.P., Pinedo, H.M., von demBorne, A.E. and van derSchoot, C.E. (1995) Expression of adhesion molecules on CD34+ cells: CD34+ L-selectin+ cells predict a rapid platelet recovery after peripheral blood stem cell transplantation. Blood, 85, 3313-3319.
34. Bellucci, R., dePropris, M.S., Buccisano, F., Lisci, A., Leone, G., Tabilio, A. and deFabritiis, P. (1999) Modulation of VLA-4 and L-selectin expression on normal CD34+ cells during mobilization with G-CSF. Bone Marrow Transplant, 23, 1-8.
35. Turner, M.L., McIlwaine, K., Anthony, R.S. and Parker, A.C. (1995) Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood. Stem Cells Dayt, 13, 311-316.
36. Leavesley, D.I., Oliver, J.M., Swart, B.W., Berndt, M.C., Haylock, D.N. and Simmons, P.J. (1994) Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34+ hemopoietic progenitor cells. J Immunol, 153, 4673-4683.
37. Watanabe, T., Dave, B., Heimann, D.G., Lethaby, E., Kessinger, A. and Talmadge, J.E. (1997) GM-CSF-mobilized peripheral blood CD34+ cells differ from steady-state bone marrow CD34+ cells in adhesion molecule expression. Bone Marrow Transplant, 19, 1175-1181.
38. Stehen, R., Tjonnfjord, G.E, Gunnes-Groseth, L.A., Heldal, D. and Egeland, T. (1997) Efflux of CD34+ cells from bone marrow to peripheral blood is selective in steady-state hematopoiesis and during G-CSF administration. J Hematother, 6, 563-573.
39. Papayannopoulou, T., Craddock, C., Nakamoto, B., Piestley, G.V. and Wolf, N.S. (1995) The VLA4/ICAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen. Proc Natl Acad Sci USA, 92, 9647-9651.
40. Williams, D.A., Rios, M., Stephens, C. and Patel, V.P. (1991) Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature, 352, 438-441.
41. Stehen, R., Tjonnfjord, G.E., Gunnes-Groseth, L.A., Heldal, D. and Egeland, T. (1997) Efflux of CD34+ cells from bone marrow to peripheral blood is selective in steady-state hematopoiesis and during G-CSF administration. J Hematother, 6, 563-573.
42. Craddock, C.F., Nakamoto, B., Andrews, R.G., Priestley, G.V. and Papayannopoulou, T. (1997) Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice. Blood, 90, 4779-4788.
43. Papayannopoulou, T., Priestley, G.V. and Nakomoto, B. (1998) Anti-VLA4/ICAM-1-induced moblization requires cooperative signaling through the kit/mkit ligand pathway. Blood, 91, 2231-2239.
44. Ghaffari, S., Smadja-Joffe, F., Ooostendorp, R., Levesque, J.P., Dougherty, G., Eaves, A. and Eaves, C. (1999) CD44 isoforms in normal and leukemic hematopoiesis. Exp Hematol, 27, 978-993.
45. Camp, R.L., Kraus, T.A. and Pure, E. (1991) Variations in the cytoskeletal interaction and posttranslational modification of the CD44 homing receptor in macrophages. J Cell Biol, 115, 1283-1292.
46. Goldstein, L.A., Zhou, D.F.H., Picker, L.J., Minty, C.N., Bargatze, R.F., Ding, J.F. and Butcher, E. C. (1989) A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell, 56, 1063-1072.
47. Hughes, E.N., Colombatti, A. and August, J.T. (1981) Murine cell surface glycoproteins. J Biol Chem, 256, 1014-1021.
48. Jalkanen, S., Bargatze, R.F., de los Toyos, J. and Butcher, E.C. (1986) A lymphoid cell surface protein involved in endothelial cell recognition and lymphocyte homing in man. Eur J Immunol, 16, 1195-1202.
49. Kansas, G.S., Wood, G.S. and Daily, M.O. (1989) A family of cell-surface glycoproteins defined by a putative anti-endothelial cell receptor antibody in man. J Immunol, 142, 3050-3057.
50. Zhou, D.F.H., Ding, J.F., Picker, L.F., Bargatze, R.F., Butcher, E.C. and Goeddel, D.V. (1989) Molecular cloning and expression of Pgp-1 - The mouse homolog of the human H-CAM (Hermes) lymphocyte homing receptor. J Immunol, 143, 3390-3395.
51. Lokeshwar, V.B. and Bourguignon, L.Y. (1991) Post-translational protein modification and expression of ankyrin-binding site(s) in GP85 (Pgp-1/CD44) and its biosynthetic precursors during T-lymphoma membrane biosynthesis. J Biol Chem, 266, 17983-17989.
52. Omary, M.B., Trowbridge, I.S., Letarte, M., Kagnoff, M.F. and Isacke, C.M. (1988) Structural heterogeneity of human Pgp-1 and its relationship with p85. Immunogenetics, 27, 460-464.
53. Quackenbush, E.J., Vera, S., Greaves, A. and Letarte, M. (1990) Confirmation by peptide sequence and co-expression on various cell types of the identity of CD44 and P85 glycoprotein. Mol Immunol, 27, 947-955.
54. Bosworth, B.T., St John, T., Gallatin, W.M. and Harp, J.A. (1991) Sequence of the bovine CD44 cDNA: comparison with human and mouse sequences. Mol Immunol, 28, 1131-1135.
55. Idzerda, R.L., Carter, W.G., Nottenburg, C., Wayner, E.A., Gallatin, W.M. and St. John, T. (1989) Isolation and DNA sequence of a cDNA clone encoding a lymphocyte adhesion receptor for high endothelium. Proc Natl Acad Sci USA, 86, 4659-4663.
56. Wolffe, E.J., Gause, W.C., Pelfrey, C.M., Holland, S.M., Steinberg, A.D. and August, J.T. (1990) The cDNA sequence of mouse Pgp-1 and homology to human CD44 cell surface antigen and proteoglycan core/link proteins. J Biol Chem, 265, 341-347.
57. Goldstein, L.A. and Butcher, E.C. (1990) Identification of mRNA that encodes an alternative form of H-CAM (CD44) in lymphoid and nonlymphoid tissues. Immunogenetics, 32, 389-397.
58. Günthert, U., Hofmann, M., Rudy, W., Reber, S., Zöller, M., Haussmann, I., Matzku, S., Wenzel, A., Ponta, H. and Herrlich, P. (1991) A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell, 65, 13-24.
59. Jackson, D.G., Buckley, J. and Bell, J.I. (1992) Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain. J Biol Chem, 267, 4732-4739.
60. Screaton, G.R., Bell, M.V., Bell, J.I. and Jackson, D.G. (1993) The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human, and rat. J Biol Chem, 268, 12235-12238.
61. Tölg, C., Hofmann, M., Herrlich, P. and Ponta, H. (1993) Splicing choice from ten variant exons establishes CD44 variability. Nucleic Acids Res, 21, 1225-1229.
62. Screaton, G.R., Bell, M.V., Jackson, D.G., Comelis, F.B., Gerth, U. and Bell, J.I. (1992) Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci USA, 89, 12160-12164.
63. Cooper, D.L., Dougherty, G., Harn, H.J., Jackson, S., Baptist, E.W., Byers, J., Datta, A., Phillips, G. and Isola, N.R. (1992) The complex CD44 transcriptional unit; alternative splicing of three internal exons generates the epithelial form of CD44. Biochem Biophys Res Commun, 182, 569-578.
64. Brown, T.A., Bouchard, T., St John, T., Wayner, E. and Carter, W.G. (1991) Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons. J Cell Biol, 113, 207-221.
65. Haggerty, J.G., Bretton, R.H. and Milstone, L.M. (1992) Identification and characterization of a cell surface proteoglycan on keratinocytes. J Invest Dermatol, 99, 374-380.
66. Isola, N.R., Harn, H.J. and Cooper, D.L. (1991) Screening recombinant DNA libraries: a rapid and efficient method for isolating cDNA clones utilizing the PCR. Biotechniques,. 11, 580-582.
67. Hofmann, M., Rudy, W., Günthert, U., Zimmer, S.G., Zawadzki, V.. Zöller, M., Lichtner, R.B., Herrlich, P. and Ponta, H. (1993) A link between ras and metastatic behavior of tumor cells: ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells. Cancer Res. 53, 1516-1521.
68. Konig, H., Moll, J., Ponta, H. and Herrlich, P. (1996) Trans-acting factors regulate the expression of CD44 splice variants. EMBO J, 15, 4030-4039.
69. Culty, M., Miyake, K., Kincade, P.W., Silorski, E., Butcher, E.C., Underhill, C. and Sikorski, E. (1990) The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins. J Cell Biol, 111, 2765-2774.
70. Aruffo, A., Stamenkovic, I., Melnick, M., Underbill, C.B. and Seed, B. (1990) CD44 is the principal cell surface receptor for hyaluronate. Cell, 61, 1303-1313.
71. Stamenkovic, L., Aruffo, A., Amiot, M. and Seed, B. (1991) The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J, 10, 343-348.
72. Underhill, C. (1992) CD44: the hyaluronan receptor. J Cell Sci,. 103, 293-298.
73. Yang, B., Yang, B.L., Savani, R.C. and Turley, E.A. (1994) Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. EMBO J, 13, 286-296.
74. Miyake, K. and Kincade, P.W. (1990) A new adhesion mechanism involving hyaluronate and CD44. Curr Top Microbiol Immunol, 166, 87-90.
75. Miyake, K., Medina, K.L., Hayashi, S.I., Ono, S., Hamaoka, T. and Kincade, P.W. (1990a) Monoclonal antibodies to Pgp-1/CD44 block lympho-hernopoiesis in long-term bone marrow cultures. J Exp Med, 171, 477-488.
76. Oostendorp, R.A., Spitzer, E., Brandl, M., Eaves, C.J. and Dormer, P. (1998) Evidence for differences in the mechanisms by which antibodies against CD44 promote adhesion of erythroid and granulopoietic progenitors to marrow stromal cells. Br J Haematol. 101, 436-445.
77. Peach, R.J., Hollenbaugh, D., Stamenkovic, I. and Aruffo, A. (1993) Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J Cell Biol, 122, 257-264.
78. Liao, H.X., Levesque, M.C., Patton, K., Bergamo, B., Jones, D., Moody, M.A., Telen, M.J. and Haynes B.F. (1993) Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies. J Immunol, 151, 6490-6499.
79. Neame, S.J. and Isacke, C.M. (1993) The cytoplasmic tail of CD44 is required for basolateral localization in ephitelial MDCK cells but does not mediate association with the detergent-insoluble cytoskeleton of fibroblasts. J Cell Biol, 121, 1299-1310.
80. He, Q., Lesley, J., Hyman, R., Ishihara, K. and Kincade, P.W. (1992) Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition. J Cell Biol. 119, 1711-1719.
81. Lesley, J., Kincade, P.W. and Hyman, R. (1993b) Antibody-induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody. Eur J Immunol, 23, 1902-1909.
82. Lesley, J. and Hyman, R. (1992) CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells. Eur J Immunol, 22, 2719-2723.
83. Lokeshwar, V.B. and Bourguignon, L. Y. (1992) The lymphoma transmembrane glycoprotein GP85 (CD44) is a novel guanine nucleotide-binding protein which regulates GP85 (CD44)-ankyrin interaction. J Biol Chem, 267, 22073-22078.
84. Jalkanen, S. and Jalkanen, M. (1992) Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. J Cell Biol, 116, 817-825.
85. Lokeshwar, V.B., Fregien, N. and Bourguignon, L.Y. (1994) Ankyrin-binding domain of CD44 (Gp85) is required for the expression of hyaluronic acid-mediated adhesion function. J Cell Biol, 126, 1099-1109.
86. Ishii, S., Ford, R., Thomas, P., Nachman, A., Steele, G. Jr. and Jessup, J.M. (1993) CD44 participates in the adhesion of humancolorectal carcinoma cells to laminin and type IV collagen. Surg Oncol, 2, 255-264.
87. Toyama-Sorimachi, N. and Miyasaka, M. (1994) A novel ligand for CD44 is sulfated proteoglycan. Int Immunol, 6, 655-660.
88. Knudson, W., Bartnik, E. and Knudson, G.B. (1993) Assembly of pericellular matrices by COS-7 cells transfected with CD44 lymphocyte-homing receptor genes. Proc Natl Acad Sci USA, 90, 4003-4007.
89. Lesley, J., Hyman, R. and Kincade, P.W. (1993a) CD44 and its interaction with extracellular matrix. Adv Immunol, 54, 271-335.
90. Neame, P.J. and Barry, F.P. (1993) The link proteins. Experientia, 49, 393-402.
91. Bourguignon, L.Y., Lokeschwar, V.B., He, H., Chen, X. and Bourguignon, G.J. (1992) A CD44-like endothelial cell transmembrane glycoprotein (GP116) interacts with extracellular matrix and ankyrin. Mol Cell Biol, 12, 4464-4471.
92. Tsukita, S., Oishi, K., Sato, N., Sagara, J., Kawai, A. and Tsukita, S. (1994) ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J Cell Biol, 126, 391-401.
93. Neame, S.J. and Isacke, C.M. (1992) Phosphorylation of CD44 in vivo requires both Ser323 and Ser325, but does not regulate membrane localization or cytoskeletal interaction in epithelial cells. EMBO J, 11, 4733-4738.
94. Knudson, C.B. and Knudson, W. (1993) Hyaluronan-binding proteins in development, tissue homeostasis and disease. FASEB J, 7, 1233-1241.
95. Goshen, R., Ariel, I., Shuster, S., Hochberg, A., Vloavsky, I., deGroot, N., Ben-Rafael, Z. and Stern, R. (1996) Hyaluronan, CD44 and its variant exons in human trophoblast invasion and placental angiogenesis. Mol Hum Reprod, 2, 685-691.
96. Ruiz, P., Schwarzler, C. and Gunthert, U. (1995) CD44 isoforms during differentiation and development. Bioessays, 17, 17-24.
97. Gunthert, U., Schwarzler, C., Wittig, B., Laman, J., Ruiz, P., Stauder, R., Bloem, A., Smadja-Joffe, F., Zoller, M. and Rolink, A. (1998) Functional involvement of CD44, a family of cell adhesion molecules, in immune responses, tumour progression and haematopoiesis. Adv Exp Med Biol, 451, 43-49.
98. Naor, D., Sionov, R.V. and Ish-Shalom, D. (1997) CD44: structure, function, and association with the malignant process. Adv Cancer Res, 11, 241-319.
99. Herrlich, P., Zöller, M., Pals, S.T. and Ponta, H. (1993) CD44 splice variants: metastases meet lymphocytes. Immunol Today, 14, 395-399.
100. Zöller, M. (1996) Joint features of metastasis formation and lymphocyte maturation and activation. Curr Top Microbiol Immunol, 213/I, 215-247.
101. Long, M.W. (1992) Blood cell cytoadhesion molecules. Exp Hematol, 20, 288-301.
102. Kinashi, T. and Springer, T.A. (1994) Adhesion molecules in hematopoietic cells. Blood Cells, 20, 25-44.
103. Lewinsohn, D.M., Nagler, A., Ginzton, N., Greenberg, P. and Butcher, B.C. (1990) Hematopoietic progenitor cell expression of the H-CAM (CD44) homing-associated adhesion molecule. Blood. 75, 589-595.
104. Berg, E.L., Goldstein, L.A., Jutila, M.A., Nakache, M., Picker, L.P., Streeter, P.R., Wu, N.W., Zhou, D. and Butcher, E.C. (1989) Homing receptors and vascular addressins: Cell adhesion molecules that direct lymphocyte traffic. Immunol Rev, 108, 5-18.
105. Picker, L.J., Nakache, M. and Butcher, E.C. (1989) Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell types. J Cell Biol, 109, 927-937.
106. Sethi, A., Gote, L., Nagarkatti, M. and Nagarkatti, P.S. (1991) T-cell-receptor-independent activation of cytolytic activity of cytotoxic T lymphocytes mediated through CD44 and gp90MEL-14. Proc Natl Acad Sci USA, 88, 7877-7881.
107. Dianzani, U. and Malavasi, F. (1995) Lymphocyte adhesion and endothelium. Crit Rev Immunol, 15, 167-200.
108. Shimizu, Y. and Shaw, S. (1991) Lymphocyte interactions with extracellular matrix. FASEB J, 5, 2292-2299.
109. Wang, W. (1993) Functional studies of adhesion molecules on CD4-CD8-double negative T cells of autoimmune MRL/Mp-lpr/mice. Hokkaido Igaku Zasschi, 68, 755-766.
110. Tan, P.H., Santos, E.B., Rossbach, H.C. and Sandmaier, B.M. (1993) Enhancement of natural killer activity by an antibody to CD44. J Immunol, 150, 812-820.
111. Yang, H. and Binns, R.M. (1993) CD44 is involved in porcine natural cytotoxicity. Cell Immunol, 149, 227-236.
112. Weber, B., Rösel, M., Arch, R., Möller, P. and Zöller, M. (1996) Expression of variant isoforms of CD44 during ontogeny of the rat: evidence for divergent functions of distinct exon combinations. Different, 60, 17-29.
113. Wirth, K., Arch, R., Somasundaram, C., Hofmann, M., Weber, B., Herrlich, P., Matzku, S. and Zöller, M. (1993) Expression of CD44 isoforms carrying metastasis-associated sequences in newborn and adult rats. Eur J Cancer, 29A, 1172-1177.
114. Terpe, H.J., Stark, H., Prehm, P. and Gunthert, U. (1994) CD44 variant isoforms are preferentially expressed in basal epithelia of non-malignant human fetal and adult tissues. Histochemistry, 101, 79-89.
115. Terpe, A., Franke, F., Stark, H., Gustmann, C., Mackay, C., Marston, W. and Gunthert, U. (1993) Occurrence of CD44 and its isoforms under orthological and pathological conditions. Verh Dtsch Ges Pathol, 77, 276-281.
116. Fox, S.B., Fawcett, J., Jackson, D.G., Collins, I., Gatter, K.C., Harris, A.L., Gearing, A. and Simmons, D.L. (1994) Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms. Cancer Res, 54, 4539-4546.
117. Hirano, H., Screaton, G.R., Bell, M.V. Jackson, D.G., Bell, J.I. and Hodes, R.J. (1994) CD44 isoform expression mediated by alternative splicing: tissue-specific regulation in mice. Int Immunol, 6, 49-59.
118. Kennel, S.J., Lankford, T.K., Foote, L.J., Shinpock, S.G. and Stringer, C. (1993) CD44 expression on murine tissues. J Cell Sci, 104, 373-382.
119. Zöller, M., Herrmann, K., Büchner, S., Seiter, S., Claas, C. and Möller, P. (1997) Transient absence of CD44 expression and delay in development by anti-CD44 treatment during ontogeny: a knock-out surrogate? Cell Growth Differentiation, 8, 1211-1223.
120. Hardingham, T.E. and Fosang, A.J. (1992) Proteoglycans: many forms and many functions. FASEB J, 6, 861-70.
121. Haynes, B.F., Liao, H.X. and Patton, K.L. (1991) The transmembrane hyaluronate receptor (CD44): Multiple functions, multiple forms. Cancer Cells, 3, 347-350.
122. Günthert, U. (1993) CD44: a multitude of isoforms with diverse functions. Curr Top Microbiol Immunol, 184, 47-73.
123. Marquez, C., Trigueros, C., Fernandez, E. and Toribio, M.L., (1995) The development of T and non-T cell lineages from CD34+ human thymic precursors can be traced by the differential expression of CD44. J Exp Med. 181, 475-483.
124. Neu, S., Geiselhart, A., Sproll, M., Hahn, D., Kuci, S., Niethammer, D. and Handgretinger, R. (1997) Expression of CD44 isoforms by highly enriched CD34-positive cells in cord blood, bone marrow and leukaphereses. Bone Marrow Transplant, 20, 593-598.
125. Krizanac-Bengez, L., Moore, P.F., Barsoukov, A. and Sandmaier, B.M. (1998) The expression and differentiation pattern of cell antigens and adhesion molecules on the nonadherent cell population in canine long-term marrow culture: a biphasic development of myeloid and lymphoid cells. Tissue Antigens, 51, 141-155.
126. Voura, E.B., Billia, F., Iscove, N.N. and Hawley, R.G. (1997) Expression mapping of adhesion receptor genes during differentiation of individual hematopoietic precursors. Exp Hematol, 25, 1172-1179.
127. Ghaffari, S., Smadja-Joffe, F., Ooostendorp, R., Levesque, J.P., Dougherty, G., Eaves, A. and Eaves, C. (1999) CD44 isoforms in normal and leukemic hematopoiesis. Exp Hematol, 27, 978-993.
128. Clark, B.R., Gallagher, J.T. and Dexter, T.M. (1992) Cell adhesion in the stromal regulation of haemopoiesis. Baillieres Clin Haematol, 5, 619-652.
129. Reuss-Borst, M.A., Buhring, H.J., Klein, G. and Muller, C.A. (1992) Adhesion molecules on CD34+ hematopoietic cells in normal human bone marrow and leukemia. Ann Hematol, 65, 169-174.
130. Ghaffari, S., Dougherty, G.J., Lansdorp, P.M., Eaves, A.C. and Eaves, C.J. (1995) Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia. Blood, 86, 2976-2985.
131. Horst, E., Meijer, C.J., Radaskiewicz, T., van Dongen, J.J., Pieters, R., Figdor, C.G., Hooftman, A. and Pals, S.T. (1990b) Expression of a human homing receptor (CD44) in lymphoid malignancies and related stages of lymphoid development. Leukemia, 4, 383-389.
132. Antica, M., Wu, L., Shortman, K. and Scollay, R. (1994) Thymic stem cells in mouse bone marrow. Blood, 84, 111-117.
133. Kansas, G.S., Muirhead, M.J. and Dailey, M.O. (1990) Expression of the CD11/CD18, leukocyte adhesion molecule 1. and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans. Blood, 76, 2483-2492.
134. Sugimoto, K., Tsurumaki, Y., Hoshi, H., Kadowaki, S., LeBousse-Kerdiles, M.C., Smadja-Joffe, F. and Mori, K.J. (1994) Effects of anti-CD44 monoclonal antibody on adhesion of erythroid leukemic cells (ELM-I-1) to hematopoietic supportive cells (MS-5): CD44, but not hyaluronate-mediated, cell-cell adhesion. Exp Hematol, 22, 488-494.
135. Lepesant, H., Reggio, H., Pierres, M. and Naquet, P. (1990) Mouse thymic epithelial cell lines interact with and select a CD3lowCD4+CD8+ thymocyte subset through an LFA-1-dependent adhesion-de-adhesion mechanism. Int Immunol, 2, 1021-1032.
136. Bell, S.E. and Zamoyska, R. (1991) Identification of thymocyte precursors in murine fetal liver. Eur J Immunol, 21, 2931-2936.
137. Haig, D.M., Thomson, J. and Percival, A. (1992) Purification and adhesion receptor phenotype of bovine bone marrow-derived haemopoietic colony-forming cells. Vet Immunol Immunopathol, 33, 223-236.
138. Horst, E., Meijer, C.J., Duijvestijn, A.M., Hartwig, N., Van der Harten, H.J. and Pals, S.T. (1990) The ontogeny of human lymphocyte recirculation: High endothelial cell antigen (HECA-452) and CD44 homing receptor expression in the development of the immune system. Eur J Immunol, 20, 1483-1489.
139. Lund-Johansen, F. and Terstappen, L.W. (1993) Differential surface expression of cell adhesion molecules during granulocyte maturation. J Leukoc Biol, 54, 47-55.
140. Ryan, D.H. (1993) Adherence of normal and neoplastic human B cell precursors to the bone marrow microenvironment. Blood Cells, 19, 225-241.
141. Collado, A., de Andres, A., Canadas, E., Ruiz-Cabello, F., Gomez, O., Pedrinaci, S. and Garrido, F. (1991) Characterization of CD44 antigen during lymphoid ontogeny. Immunobiology, 183, 1-11.
142. Patel, D.D., Hale, L.P., Whichard, L.P., Radcliff, G., Mackay, C.R. and Haynes, B.F. (1995) Expression of CD44 molecules and CD44 ligands during human thymic fetal development: expression of CD44 isoforms is depvelopmentally regulated. Int Immunol, 7, 277-286.
143. Valent, P., Majdic, O., Maurer, D., Bodger, M., Muhm, M. and Bettelheim, P. (1990) Further characterization of surface membrane structures expressed on human basophils and mast cells. Int Arch Allergy Appl Immunol, 91, 198-203.
144. Delfino, D.V., Patrene, K.D., DeLeo, A.B., Deleo, R., Herberman, R.B. and Boggs, S.S. (1994) Role of CD44 in the development of natural killer cells from precursors in long-term cultures of mouse bone marrow. J Immunol, 152, 5171-5179.
145. Jackson, D.G., Bell, J.I., Dickinson, R., Timans, J., Shields, J. and Whittle, N. (1995) Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. J Cell Biol, 128, 673-685.
146. Koopman, G., Heider, K.H., Horst, E., Adolf, G.R., van den Berg, F., Ponta, H., Herrlich, P. and Pals, S.T. (1993b) Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44. J Exp Med, 177, 897-904.
147. Dommann, S.N., Ziegler, T., Dommann-Schener, C.C., Meyer, J., Panizzon, R. and Burg, G. (1995) CD44v6 is a marker for systemic spread in cutaneous T-cell lymphomas. A comparative study between nodal and cutaneous lymphomas. J Cutan Pathol, 22, 407-412.
148. Legras, S., Gunthert, U., Stauder, R., Curt, F., Oliferenko, S., Kluin-Nelemans, H.C., Marie, J.P., Proctor, S., Jasmin, C. and Smadja-Jotle, F. (1998) A strong expression of CD44v6 correlates with shorter survival of patients with acute myeloid leukemia. Blood, 91, 3401-3413.
149. Christ, O., Schmidt, D.S., Gunthert, U., Kronenwett, R., Haas, R. and Zoller, M. (1999 Abstract) Mobilization of hematopoitic progenitor cells by blockade of adhesion: comparison between G-CSF and distinct CD44 isoforms. Immunobiol, 200, 526-527.
150. Stauder, R., VanDriel, M., Schwarzler, C., Thaler, J., Lokhorst, H.M., Kreuser, E.D., Bloem, A.C., Gunthert, U. and Eisterer, W. (1996) Different CD44 splicing patterns define prognostic subgroups in multiple myeloma. Blood, 88, 3101-3108.
151. Stauder, R., Eisterer, W., Thaler, J. and Gunthert, U. (1995) CD44 variant isoforms in non-Hodgkin's lymphoma: a new independent prognostic factor. Blood, 85, 2885-2899.
152. Beham-Schmid, C., Heider, K.H., Hoefler, G. and Zatloukal, K. (1998) Expression of CD44 splice variant v10 in Hodgkin's disease is associated with aggressive behaviour and high risk of relapse. J Pathol, 186, 383-389.
153. Wagner, S.N., Wagner, C. Reinhold, U., Funk, R., Zoller, M. and Goos, M. (1998) Predominant expression of CD44 splice variant v10 in malignant and reactive human skin lymphocytes. J Invest Dermatol, 111, 464-471.
154. Charrad, R.S., Li, Y., Delpech, B., Balitrand, N., Clay, D., Jasmin, C., Chomienne, C. and Smadja-Joffe, F. (1999) Ligation of CD44 adhesion molecules reverses blockade of differentiation in human acute myeloid leukemia. Nature Med, 5, 669-676.
155. Verfaillie, C.M., Benis, A., Iiida, J., McGlave, P.B. and McCarthy, J.B. (1994) Adhesion of committed hematopoietic progenitors to synthetic peptides from the C-terminal heparin-binding domain of fibroncctin: cooperation between the integrin alpha 4 beta 1 and CD44 adhesion receptor. Blood; 84, 1802-1811.
156. Sugimoto, K., Tsurukami, Y., Hoshi, H., Kadowaki, S., LeBousse-Kerdiles, M.C., Smadja-Joffe, F. and Mori, K.J. (1994) Effects of anti-CD44 monoclonal antibody on adhesion of erythroid leukemic cells (ELM-I-1) to hematopoietic supportive cells (MS-5): CD44, but not hyaluronate-mediated, cell-cell adhesion. Exp Hematol, 22, 488-494.
157. Smadja-Joffe, F., Legras, S., Girard, N., Li, Y., Delpech, B., Bloget, E. Morimoto, K., LeBousse-Kerdiles, C., Clay, D., Jasmin, C. and Levesque, J.P. (1996) CD44 and hyaluronan binding by human myeloid cells. Leuk Lymphoma, 21, 407-420.
158. Rossbach, H.C., Krizanac-Bengez, L., Santos, E.B., Gooley, T.A. and Sandmaier, B.M. (1996) An antibody to CD44 enhances hematopoiesis in long-term marrow cultures. Exp Hematol, 24, 221-227.
159. Khaldoyanidi, S., Moll, J., Karakhanova, S., Herrlich, P. and Ponta, H. (1999) Hyaluronate-enhanced hematopoiesis: two different receptors trigger the release of interleukin-1 beta and interleukin-6 from bone marrow macrophages. Blood, 94, 940-949.
160. Lundell, B.I., McCarthy, J.B., Kovach, N.L. and Verfaillie, C.M. (1997) Activation of beta 1 integrins on CML progenitors reveals cooperation between
161. Ghaffari, S., Dougherty, G.J., Eaves, A.C. and Eaves, C.J. (1997) Diverse effects of anti-CD44 antibodies on the stromal cell-mediated support of normal but not leukemic (CML) haemopoiesis in vitro. Br J Haematol, 97, 22-28.
162. Wilson, J.G. (1997) Adhesive interactions in hemopoiesis. Acta Haematol, 97, 6-12.
163. Ishiwatari-Hayasaka, H., Fujimoto, T., Osawa, T., Hirama, T., Toyama-Sorimachi, N. and Miyasaka, M. (1999) Requirements for signal delivery through CD44: analysis using CD44-Fas chimeric proteins. J Immunol, 163, 1258-1264.
164. Kincade, P.W. (1991) Molecular interactions between stromal cells and B lymphocyte precursors. Semin Immunol, 3, 379-390.
165. Kincade, P.W. (1992) Cell interaction molecules and cytokines which participate in B lymphopoieses. Baillieres Clin Haematol, 5, 575-598.
166. Kincade, P.W, He, Q., Ishihara, K., Miyake, K., Lesley, J. and Hyman, R. (1993) CD44 and other cell interaction molecules contributing to B lymphopoiesis. Curr Top Microbiol Immunol, 184, 215-222.
167. Kobayashi, M., Imamura, M., Uede, T., Sakurada, K., Maeda, S., Iwasaki, H., Tsuda, Y., Musashi, M. and Miyazaki, T. (1994) Expression of adhesion molecules on human hematopoietic progenitor cells at different maturational stages. Stem Cells Dayt, 12, 316-321.
168. Khaldoyanidi, S., Denzel, A. and Zöller, M. (1996) Requirement for CD44 in stem cell proliferation and homing. J Leukoc Biol, 60, 579-592.
169. Khaldoyanidi, S., Schnabel, D., Föhr, N. and Zöller, M. (1997) Functional activity of CD44 isoforms in hematopoesis of the rat. Br J Haematol, 96, 31-45.
170. Bennett, K.L., Jackson, D.G., Simon, J.C, Tanczos, E., Peach, R., Modrell, B., Stamenkovic, I., Plowman, G. and Aruffo, A. (1995) CD44 isoforms containing exon v3 are responsible for the presentation of heparin-binding growth factor. J Cell Biol, 128, 687-698.
171. Moll, J., Khaldoyanidi, S., Sleeman, J.P., Achnicht, M., Preuss, I., Ponta, H. and Herrlich, P. (1998) Two different functions for CD44 proteins in human myelopoiesis. J Clin Invest, 102, 1024-1034.
172. Zöller, M., Schmidt, A., Denzel, A. and Moll, J. (1997) The function of CD44 variant isoforms in allogeneic bone marrow transplantation. Blood, 90, 873-885.
173. Schmits, R., Filmus, J., Gerwin, N., Senaldi, G., Kiefer, F., Kundig, T., Wakeham, A., Shahinian, A., Catzavelos, C., Rak, J., Furlonger, C., Zakarian, A., Simard, J.J., Ohashi, P.S., Paige, C.J., Gutierrez-Ramos, J.C. and Mak, T.W. (1997) CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood, 90, 2217-2233.
174. Jalkanen, S., Jalkanen, M., Bargatze, R., Tammi, M. and Butcher, E.C. (1988) Biochemical properties of glycoproteins involved in lymphocyte recognition of high endothelial venules in man. J Immunol, 141, 1615-1623.
175. Scheeren, R.A., Koopman, G., Van der Baan, S., Meijer, C.J. and Pals, S.T. (1991) Adhesion receptors involved in clustering of blood dendritic cells and T lymphocytes. Eur J Immunol, 21, 1101-1105.
176. Morimoto, K., Robin, E., Le Bousse-Kerdiles, M.C., Li, Y., Clay, D., Jasmin, C. and Smadja-Joffe, F. (1994) CD44 mediates hyaluronan binding by human myeloid KG1A and KG1 cells. Blood, 83, 657-662.
177. Verfaillie, C.M., Benis, A., Lida, J., McGlave, P.B. and McCarthy, J.B. (1994) Adhesion of committed human hematopoietic progenitors to synthetic peptides from the C-terminal heparin-binding domain of fibronectin: cooperation between the integrin alpha 4 beta 1 and the CD44 adhesion receptor. Blood, 84, 1802-1811.
178. Degrassi, A., Hilbert, D.M., Rudikoff, S., Anderson, A.O., Potter, M. and Coon, H.G. (1993) In vitro culture of primary plasmacytomas requires stromal cell feeder layers. Proc Natl Acad Sci USA, 90, 2060-2064.
179. Oppenheimer Marks, N., Davis, L.S. and Lipsky, P.E. (1990) Human T lymphocyte adhesion to endothelial cells and transendothelial migration. Alteration of receptor use relates to the activation status of both the T cell and the endothelial cell. J Immunol, 145, 140-148.
180. Lesley, J., He, Q., Miyake, K., Hamann, A., Hyman, R. and Kincade, P. W. (1992) Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody. J Exp Med, 175, 257-266.
181. Legras, S., Levesque, J.P., Charrad, R., Morimoto, K., Le-Bouuse, C., Clay, D., Jasmin, C. and Smadja-Joffe, F. (1995) CD44-mediated adhesiveness of human hematopoietic progenitors to hyaluronan is modulated by cytokines. Blood, 89, 1905-1914.
182. Pilarski, L.M., Pruski, E., Wizniak, J., Paine, D., Seeberger, K., Mant, M.J., Brown, C.B. and Belch, A.R. (1999) Potential role for hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells. Blood, 93, 2918-2927.
183. Wu, L., Kincade, P.W. and Shortman, K. (1993) The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate. Immunol Lett, 38, 69-75.