메뉴 건너뛰기




Volumn 94, Issue 3, 1999, Pages 940-949

Hyaluronate-enhanced hematopoiesis: Two different receptors trigger the release of interleukin-1β and interleukin-6 from bone marrow macrophages

Author keywords

[No Author keywords available]

Indexed keywords

HYALURONIC ACID; HYALURONIDASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PROTEIN KINASE; SYNAPTOPHYSIN;

EID: 0033179160     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.3.940.415k27_940_949     Document Type: Article
Times cited : (68)

References (61)
  • 1
    • 0026720663 scopus 로고
    • Stroma-dependent hematolymphopoietic stem cells
    • Quesenberry PJ: Stroma-dependent hematolymphopoietic stem cells. Curr Top Microbiol Immunol 177:151, 1992
    • (1992) Curr Top Microbiol Immunol , vol.177 , pp. 151
    • Quesenberry, P.J.1
  • 3
    • 0030933062 scopus 로고    scopus 로고
    • Regulatory mechanisms in stem cell biology
    • Morrison SJ, Shah NM, Anderson DJ: Regulatory mechanisms in stem cell biology. Cell 88:287, 1997
    • (1997) Cell , vol.88 , pp. 287
    • Morrison, S.J.1    Shah, N.M.2    Anderson, D.J.3
  • 5
    • 0028809457 scopus 로고
    • The extracellular matrix of the hematopoietic microenvironment
    • Klein G: The extracellular matrix of the hematopoietic microenvironment. Experientia 51:914, 1995
    • (1995) Experientia , vol.51 , pp. 914
    • Klein, G.1
  • 6
    • 0017694555 scopus 로고
    • Conditions controlling the proliferation of haemopoietic stem cells in vitro
    • Dexter TM, Allen TD, Lajtha LG: Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 91:335, 1977
    • (1977) J Cell Physiol , vol.91 , pp. 335
    • Dexter, T.M.1    Allen, T.D.2    Lajtha, L.G.3
  • 7
    • 0024207601 scopus 로고
    • Heparan sulfate is necessary for adhesive interactions between human early hemopoietic progenitor cells and the extracellular matrix of the marrow microenvironment
    • Gordon MY, Riley GP, Clarke D: Heparan sulfate is necessary for adhesive interactions between human early hemopoietic progenitor cells and the extracellular matrix of the marrow microenvironment. Leukemia 2:804, 1988
    • (1988) Leukemia , vol.2 , pp. 804
    • Gordon, M.Y.1    Riley, G.P.2    Clarke, D.3
  • 8
    • 0026770087 scopus 로고
    • Binding of primitive hematopoietic progenitor cells to marrow stromal cells involves heparan sulfate
    • Siczkowski M, Clarke D, Gordon MY: Binding of primitive hematopoietic progenitor cells to marrow stromal cells involves heparan sulfate. Blood 80:912, 1992
    • (1992) Blood , vol.80 , pp. 912
    • Siczkowski, M.1    Clarke, D.2    Gordon, M.Y.3
  • 9
    • 0020600472 scopus 로고
    • Regulation of haemopoiesis in long-term bone marrow cultures. IV. Glycosaminoglycan synthesis and the stimulation of haemopoiesis by beta-D-xylosides
    • Spooncer E, Gallagher JT, Krizsa F, Dexter TM: Regulation of haemopoiesis in long-term bone marrow cultures. IV. Glycosaminoglycan synthesis and the stimulation of haemopoiesis by beta-D-xylosides. J Cell Biol 96:510, 1983
    • (1983) J Cell Biol , vol.96 , pp. 510
    • Spooncer, E.1    Gallagher, J.T.2    Krizsa, F.3    Dexter, T.M.4
  • 10
    • 0028146155 scopus 로고
    • Adhesion of committed human hematopoietic progenitors to synthetic peptides from the C-terminal heparin-binding domain of fibronectin: Cooperation between the integrin alpha 4 beta 1 and the CD44 adhesion receptor
    • Verfaillie CM, Benis A, Iida J, McGlave PB, McCarthy JB: Adhesion of committed human hematopoietic progenitors to synthetic peptides from the C-terminal heparin-binding domain of fibronectin: Cooperation between the integrin alpha 4 beta 1 and the CD44 adhesion receptor. Blood 84:1802, 1994
    • (1994) Blood , vol.84 , pp. 1802
    • Verfaillie, C.M.1    Benis, A.2    Iida, J.3    McGlave, P.B.4    McCarthy, J.B.5
  • 11
    • 0027894176 scopus 로고
    • Is hyaluronic acid the "organizer" of the extracellular matrix in marrow stroma?
    • Minguell JJ: Is hyaluronic acid the "organizer" of the extracellular matrix in marrow stroma? [editorial; comment]. Exp Hematol 21:7, 1993
    • (1993) Exp Hematol , vol.21 , pp. 7
    • Minguell, J.J.1
  • 12
    • 0027491845 scopus 로고
    • CD44 and its interaction with extracellular matrix
    • Lesley J, Hyman R, Kincade PW: CD44 and its interaction with extracellular matrix. Adv Immunol 54:271, 1993
    • (1993) Adv Immunol , vol.54 , pp. 271
    • Lesley, J.1    Hyman, R.2    Kincade, P.W.3
  • 13
    • 0020067501 scopus 로고
    • Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues
    • Trowbridge IS, Lesley J, Schulte R, Hyman R, Trotter J: Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics 15:299, 1982
    • (1982) Immunogenetics , vol.15 , pp. 299
    • Trowbridge, I.S.1    Lesley, J.2    Schulte, R.3    Hyman, R.4    Trotter, J.5
  • 14
    • 0025677446 scopus 로고
    • Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans
    • Kansas GS, Muirhead MJ, Dailey MO: Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans. Blood 76:2483, 1990
    • (1990) Blood , vol.76 , pp. 2483
    • Kansas, G.S.1    Muirhead, M.J.2    Dailey, M.O.3
  • 15
    • 0027269982 scopus 로고
    • Identification of hyaluronic acid binding sites in the extracellular domain of CD44
    • Peach RJ, Hollenbaugh D, Stamenkovic I, Aruffo A: Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J Cell Biol 122:257, 1993
    • (1993) J Cell Biol , vol.122 , pp. 257
    • Peach, R.J.1    Hollenbaugh, D.2    Stamenkovic, I.3    Aruffo, A.4
  • 16
    • 0028097742 scopus 로고
    • Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein
    • Yang B, Yang BL, Savani RC, Turley EA: Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. EMBO J 13:286, 1994
    • (1994) EMBO J , vol.13 , pp. 286
    • Yang, B.1    Yang, B.L.2    Savani, R.C.3    Turley, E.A.4
  • 17
    • 0025137103 scopus 로고
    • Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures
    • Miyake K, Medina KL, Hayashi S, Ono S, HamaokaT, Kincade PW: Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures. J Exp Med 171:477, 1990
    • (1990) J Exp Med , vol.171 , pp. 477
    • Miyake, K.1    Medina, K.L.2    Hayashi, S.3    Ono, S.4    Hamaoka, T.5    Kincade, P.W.6
  • 19
    • 0020957871 scopus 로고
    • Effects of detergent solubilization on the hyaluronate-binding protein from membranes of simian virus 40-transformed 3T3 cells
    • Underbill CB, Chi-Rosso G, Toole BP: Effects of detergent solubilization on the hyaluronate-binding protein from membranes of simian virus 40-transformed 3T3 cells. J Biol Chem 258:8086, 1983
    • (1983) J Biol Chem , vol.258 , pp. 8086
    • Underbill, C.B.1    Chi-Rosso, G.2    Toole, B.P.3
  • 20
    • 0020054847 scopus 로고
    • Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line
    • Lee JC, Hapel AJ, Ihle JN: Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line. J Immunol 128:2393, 1982
    • (1982) J Immunol , vol.128 , pp. 2393
    • Lee, J.C.1    Hapel, A.J.2    Ihle, J.N.3
  • 21
    • 0020557297 scopus 로고
    • Effect of mouse interferon on growth and differentiation of mouse bone marrow cells stimulated by two different types of colony-stimulating factor
    • Yamamoto-Yamaguchi Y, Tomida M, Hozumi M: Effect of mouse interferon on growth and differentiation of mouse bone marrow cells stimulated by two different types of colony-stimulating factor. Blood 62:597, 1983
    • (1983) Blood , vol.62 , pp. 597
    • Yamamoto-Yamaguchi, Y.1    Tomida, M.2    Hozumi, M.3
  • 22
    • 0023872192 scopus 로고
    • Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors
    • Karasuyama H, Melchers F: Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur J Immunol 18:97, 1988
    • (1988) Eur J Immunol , vol.18 , pp. 97
    • Karasuyama, H.1    Melchers, F.2
  • 23
    • 0031009021 scopus 로고    scopus 로고
    • Hyaluronan-independent lodgment of CD44+ lymphoma cells in lymphoid organs
    • Vogt Sionov R, Naor D: Hyaluronan-independent lodgment of CD44+ lymphoma cells in lymphoid organs. Int J Cancer 71:462, 1997
    • (1997) Int J Cancer , vol.71 , pp. 462
    • Vogt Sionov, R.1    Naor, D.2
  • 25
    • 0011263499 scopus 로고
    • Long-term culture of B lymphocytes and their precursors from murine bone marrow
    • Whitlock CA, Witte ON: Long-term culture of B lymphocytes and their precursors from murine bone marrow. Proc Natl Acad Sci USA 79:3608, 1982
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 3608
    • Whitlock, C.A.1    Witte, O.N.2
  • 26
    • 0027436663 scopus 로고
    • Spectrophotometric method for the assay of glycosaminoglycans and glycosaminoglycan-depolymerizing enzymes
    • Homer KA, Denbow L, Beighton D: Spectrophotometric method for the assay of glycosaminoglycans and glycosaminoglycan-depolymerizing enzymes. Anal Biochem 214:435, 1993
    • (1993) Anal Biochem , vol.214 , pp. 435
    • Homer, K.A.1    Denbow, L.2    Beighton, D.3
  • 27
    • 0026316192 scopus 로고
    • Expression of interferon-beta during the triggering phase of macrophage cytocidal activation. Evidence for an autocrine/paracrine role in the regulation of this state
    • Riches DW, Underwood GA: Expression of interferon-beta during the triggering phase of macrophage cytocidal activation. Evidence for an autocrine/paracrine role in the regulation of this state. J Biol Chem 266:24785, 1991
    • (1991) J Biol Chem , vol.266 , pp. 24785
    • Riches, D.W.1    Underwood, G.A.2
  • 28
    • 0345713237 scopus 로고
    • Hemopoiesis
    • Oxford, UK, Oxford University Press
    • Testa JE, Molineux: Hemopoiesis. A Practical Approach. Oxford, UK, Oxford University Press, 1993
    • (1993) A Practical Approach
    • Testa, J.E.1
  • 29
    • 0016578453 scopus 로고
    • Preparation and properties of fluoresceinlabelled hyaluronate
    • de Beider AN, Wik KO: Preparation and properties of fluoresceinlabelled hyaluronate. Carbohydr Res 44:251, 1975
    • (1975) Carbohydr Res , vol.44 , pp. 251
    • De Beider, A.N.1    Wik, K.O.2
  • 30
    • 0030047838 scopus 로고    scopus 로고
    • Cytoskeleton-membrane interactions
    • published erratum appears in Curr Opin Cell Biol 8:244, 1996
    • Cowin P, Burke B: Cytoskeleton-membrane interactions [published erratum appears in Curr Opin Cell Biol 8:244, 1996]. Curr Opin Cell Biol 8:56, 1996
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 56
    • Cowin, P.1    Burke, B.2
  • 31
    • 0022968612 scopus 로고
    • Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages
    • Hiro D, Ito A, Matsuta K, Mori Y: Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages. Biochem Biophys Res Commun 140:715, 1986
    • (1986) Biochem Biophys Res Commun , vol.140 , pp. 715
    • Hiro, D.1    Ito, A.2    Matsuta, K.3    Mori, Y.4
  • 32
    • 0027242026 scopus 로고
    • Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages
    • Noble PW, Lake FR, Henson PM, Riches DW: Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages. J Clin Invest 91:2368, 1993
    • (1993) J Clin Invest , vol.91 , pp. 2368
    • Noble, P.W.1    Lake, F.R.2    Henson, P.M.3    Riches, D.W.4
  • 33
    • 0029935418 scopus 로고    scopus 로고
    • Regulation of transcription by MAP kinase cascades
    • Treisman R: Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8:205, 1996
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 205
    • Treisman, R.1
  • 34
    • 0031309902 scopus 로고    scopus 로고
    • The discoidin domain receptor tyrosine kinases are activated by collagen
    • Vogel W, Gish GD, Alves F, Pawson T: The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1:13, 1997
    • (1997) Mol Cell , vol.1 , pp. 13
    • Vogel, W.1    Gish, G.D.2    Alves, F.3    Pawson, T.4
  • 36
    • 0343163257 scopus 로고
    • Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors
    • Ikebuchi K, Wong GG, Clark SC, Ihle JN, Hirai Y, Ogawa M: Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci USA 84:9035, 1987
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9035
    • Ikebuchi, K.1    Wong, G.G.2    Clark, S.C.3    Ihle, J.N.4    Hirai, Y.5    Ogawa, M.6
  • 38
    • 0024243903 scopus 로고
    • Effect of interleukin 6 (IL-6) on the differentiation and proliferation of murine and human hemopoietic progenitors
    • Suda T, Yamaguchi Y, Suda J, Miura Y, Okano A, Akiyama Y: Effect of interleukin 6 (IL-6) on the differentiation and proliferation of murine and human hemopoietic progenitors. Exp Hematol 16:891, 1988
    • (1988) Exp Hematol , vol.16 , pp. 891
    • Suda, T.1    Yamaguchi, Y.2    Suda, J.3    Miura, Y.4    Okano, A.5    Akiyama, Y.6
  • 39
    • 0027820552 scopus 로고
    • Rat stem cell factor and IL-6 preferentially support the proliferation of c-kit-positive murine hemopoietic cells rather than their differentiation
    • Miura N, Okada S, Zsebo KM, Miura Y, Suda T: Rat stem cell factor and IL-6 preferentially support the proliferation of c-kit-positive murine hemopoietic cells rather than their differentiation. Exp Hematol 21:143, 1993
    • (1993) Exp Hematol , vol.21 , pp. 143
    • Miura, N.1    Okada, S.2    Zsebo, K.M.3    Miura, Y.4    Suda, T.5
  • 40
    • 0024473974 scopus 로고
    • Regulation of megakaryocyte development by interleukin-6
    • Lotem J, Shabo Y, Sachs L: Regulation of megakaryocyte development by interleukin-6. Blood 74:1545, 1989
    • (1989) Blood , vol.74 , pp. 1545
    • Lotem, J.1    Shabo, Y.2    Sachs, L.3
  • 43
    • 0028675983 scopus 로고
    • Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system
    • Bernad A, Kopf M, Kulbacki R, Weich N, Koehler G, Gutierrez-Ramos JC: Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system. Immunity 1:725, 1994
    • (1994) Immunity , vol.1 , pp. 725
    • Bernad, A.1    Kopf, M.2    Kulbacki, R.3    Weich, N.4    Koehler, G.5    Gutierrez-Ramos, J.C.6
  • 44
    • 0023905175 scopus 로고
    • Synergism among interleukin 1, interleukin 3, and interleukin 5 in the production of eosinophils from primitive hemopoietic stem cells
    • Warren DJ, Moore MA: Synergism among interleukin 1, interleukin 3, and interleukin 5 in the production of eosinophils from primitive hemopoietic stem cells. J Immunol 140:94, 1988
    • (1988) J Immunol , vol.140 , pp. 94
    • Warren, D.J.1    Moore, M.A.2
  • 45
    • 0024801831 scopus 로고
    • The role of interleukin 6 and interleukin 1 in megakaryocyte development
    • Warren MK, Conroy LB, Rose JS: The role of interleukin 6 and interleukin 1 in megakaryocyte development. Exp Hematol 17:1095, 1989
    • (1989) Exp Hematol , vol.17 , pp. 1095
    • Warren, M.K.1    Conroy, L.B.2    Rose, J.S.3
  • 46
    • 0027894177 scopus 로고
    • IL-1 beta inhibits adipocyte formation in human long-term bone marrow culture
    • Delikat S, Harris RJ, Galvani DW: IL-1 beta inhibits adipocyte formation in human long-term bone marrow culture. Exp Hematol 21:31, 1993
    • (1993) Exp Hematol , vol.21 , pp. 31
    • Delikat, S.1    Harris, R.J.2    Galvani, D.W.3
  • 48
    • 0031031002 scopus 로고    scopus 로고
    • Functional activity of CD44 isoforms in haemopoiesis of the rat
    • Khaldoyanidi S, Schnabel D, Fohr N, Zoller M: Functional activity of CD44 isoforms in haemopoiesis of the rat. Br J Haematol 96:31, 1997
    • (1997) Br J Haematol , vol.96 , pp. 31
    • Khaldoyanidi, S.1    Schnabel, D.2    Fohr, N.3    Zoller, M.4
  • 50
    • 0030934225 scopus 로고    scopus 로고
    • Diverse effects of anti-CD44 antibodies on the stromal cell-mediated support of normal but not leukaemic (CML) haemopoiesis in vitro
    • Ghaffari S, Dougherty GJ, Eaves AC, Eaves CJ: Diverse effects of anti-CD44 antibodies on the stromal cell-mediated support of normal but not leukaemic (CML) haemopoiesis in vitro. Br J Haematol 97:22, 1997
    • (1997) Br J Haematol , vol.97 , pp. 22
    • Ghaffari, S.1    Dougherty, G.J.2    Eaves, A.C.3    Eaves, C.J.4
  • 52
    • 0028090359 scopus 로고
    • Intercellular adhesion molecule-1 is a cell surface receptor for hyaluronan
    • McCourt PA, Ek B, Forsberg N, Gustafson S: Intercellular adhesion molecule-1 is a cell surface receptor for hyaluronan. J Biol Chem 269:30081, 1994
    • (1994) J Biol Chem , vol.269 , pp. 30081
    • McCourt, P.A.1    Ek, B.2    Forsberg, N.3    Gustafson, S.4
  • 53
    • 0030774117 scopus 로고    scopus 로고
    • On the adsorption of hyaluronan and ICAM-1 to modified hydrophobic resins
    • McCourt PA, Gustafson S: On the adsorption of hyaluronan and ICAM-1 to modified hydrophobic resins. Int J Biochem Cell Biol 29:1179, 1997
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 1179
    • McCourt, P.A.1    Gustafson, S.2
  • 54
    • 0025966878 scopus 로고
    • Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells
    • Turley EA, Austen L, Vandeligt K, Clary C: Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells. J Cell Biol 112:1041, 1991
    • (1991) J Cell Biol , vol.112 , pp. 1041
    • Turley, E.A.1    Austen, L.2    Vandeligt, K.3    Clary, C.4
  • 55
    • 0026645557 scopus 로고
    • Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility
    • published erratum appears in J Cell Biol 118:753, 1992
    • Hardwick C, Hoare K, Owens R, Hohn HP, Hook M, Moore D, Cripps V, Austen L, Nance DM, Turley EA: Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility [published erratum appears in J Cell Biol 118:753, 1992]. J Cell Biol 117:1343, 1992
    • (1992) J Cell Biol , vol.117 , pp. 1343
    • Hardwick, C.1    Hoare, K.2    Owens, R.3    Hohn, H.P.4    Hook, M.5    Moore, D.6    Cripps, V.7    Austen, L.8    Nance, D.M.9    Turley, E.A.10
  • 57
    • 0031850550 scopus 로고    scopus 로고
    • The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells
    • Assmann V, Marshall JF, Fieber C, Hofmann M, Hart IR: The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells. J Cell Sei 111:1685, 1998
    • (1998) J Cell Sei , vol.111 , pp. 1685
    • Assmann, V.1    Marshall, J.F.2    Fieber, C.3    Hofmann, M.4    Hart, I.R.5
  • 59
    • 0030917306 scopus 로고    scopus 로고
    • Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation
    • Kaya G, Rodriguez I, Jorcano JL, Vassalli P, Stamenkovic I: Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. Genes Dev 11:996, 1997
    • (1997) Genes Dev , vol.11 , pp. 996
    • Kaya, G.1    Rodriguez, I.2    Jorcano, J.L.3    Vassalli, P.4    Stamenkovic, I.5
  • 60
    • 0032054745 scopus 로고    scopus 로고
    • A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth
    • Sherman L, Wainwright D, Ponta H, Herrlich P: A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth. Genes Dev 12:1058, 1998
    • (1998) Genes Dev , vol.12 , pp. 1058
    • Sherman, L.1    Wainwright, D.2    Ponta, H.3    Herrlich, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.