Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 8, 2000, Pages 2085-2094

  Chan, Wai N ^a   Hadley, Michael S ^a   Harling, John D ^a   Herdon, Hugh J ^a   Orlek, Barry S ^a   Riley, Graham J ^a   Stead, Rachel E A ^a   Stean, Tania O ^a   Thompson, Mervyn ^a   Upton, Neil ^a   Ward, Robert W ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDROISOQUINOLINYL BENZAMIDE DERIVATIVE; ANTICONVULSIVE AGENT; BENZAMIDE DERIVATIVE; CARABERSAT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; EPILEPSY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; BENZAMIDES; BENZOPYRANS; BINDING SITES; BRAIN CHEMISTRY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ISOQUINOLINES; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RATS; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0033868127     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00149-8     Document Type: Article

References (24)

1. Leach J.P., Brodie M.J. Seizure. 4:1995;5.
2. Upton N. Trends Pharmacol. Sci. 15:1994;456.
3. Blackburn T.P., Buckingham R.E., Chan W.N., Evans J.M., Hadley M.S., Thompson M., Upton N., Stemp G., Vong A.K. Bioorg. Med. Chem. Lett. 5:1995;1163.
4. Chan W.N., Evans J.M., Hadley M.S., Herdon H.J., Jerman J.C., Morgan H.K.A., Stean T.O., Thompson M., Upton N., Vong A.K. J. Med. Chem. 39:1996;4537. and references cited within. Additional information can also be found in refs 12 and 14 in this manuscript.
5. (a) Preliminary results are in: Herdon, H.; Jerman, J.; Stean, T. O.; Chan, W.; Middlemiss, D. N.; Upton, N. Eur. J. Pharmacol. 1996, 314, R7;
6. (b) Herdon, H.; Jerman, J. C.; Chan, W. Patent Cooperation Treaty Application. WO96/18650, 1996; Chem. Abstr. 1996, 125, 105148.
7. (b) Herdon, H.; Jerman, J. C.; Chan, W. Patent Cooperation Treaty Application. WO96/18650, 1996; Chem. Abstr. 1996, 125, 105148.
8. Herdon H.J., Jerman J.C., Stean T.O., Middlemiss D.N., Chan W.N., Vong A.K., Evans J.M., Thompson M., Upton N. Brit. J. Pharmacol. 121:1997;1687.
9. Chan W.N., Hadley M.S., Harling J.D., Herdon H.J., Jerman J.C., Orlek B.S., Stean T.O., Thompson M., Upton N., Ward R.W. Bioorg. Med. Chem. Lett. 8:1998;2903.
10. (a) Mathison, I. M.; Fowler, K. C.; Morgan, P. H.; Tidwell, R. R.; Peters, E. R. J. Med. Chem. 1973, 16, 332.
11. (b) Stokker, G. E. Tetrahedron Lett. 1996, 37, 5433.
12. (a) Harling, J. D.; Orlek, B. S.; Thompson, M. Patent Cooperation Treaty Application WO97/48683, 1997 128, 10213 and references cited therein; Chem. Abstr. 1997.
13. (a) Harling, J. D.; Orlek, B. S.; Thompson, M. Patent Cooperation Treaty Application WO97/48683, 1997 128, 10213 and references cited therein; Chem. Abstr. 1997.
14. (b) Thompson, M.; Harling, J. D.; Edwards, P. D. Patent Cooperation Treaty Application WO99/21836 and references cited therein; Chem. Abstr. 1999, 130, 325093.
15. (b) Thompson, M.; Harling, J. D.; Edwards, P. D. Patent Cooperation Treaty Application WO99/21836 and references cited therein; Chem. Abstr. 1999, 130, 325093.
16. Carrera G.M., Garvey D.S. J. Heterocycl. Chem. 29:1992;847.
17. (a) Abdel-Magid, F. A.; Carson, K. G.; Harris, B. D.; Maryanoff, C. A.; Shah, R. D. J. Org. Chem. 1996, 61, 3849.
18. (b) Abdel-Magid, F. A.; Carson, K. G.; Maryanoff, C. A. Tetrahedron Lett. 1990, 31, 5595.
19. Upton N., Blackburn T.P., Campbell C.A., Cooper D., Evans M.L., Herdon H.J., King P.D., Ray A.M., Stean T.O., Chan W.N., Evans J.M., Thompson M. Brit. J. Pharmacol. 121:1997;1679.
20. SYBYL, Tripos Associates, Inc., 1699 S. Hanley Rd, Suite 303, St. Louis, MO 63144, USA.
21. Upton, N.; Thompson, M. In Progress in Medicinal Chemistry; King, F. D., Oxford, A. W., Eds.; Elsevier Science: Oxford, 2000; Vol. 37, pp 177-200.
22. Dixon W.J., Mood A.M. J . Amer. Stat. Assn. 43:1948;109.
23. Upton N., Stean T., Middlemiss D., Blackburn, Kennett G. Eur. J. Pharmacol. 359:1998;33.
24. Litchfield J.T., Wilcoxon F. J. Pharmacol. Exp Ther. 96:1949;99.