Synthesis of novel trans-4-(substituted-benzamido)-3,4-dihydro-2H- benzo[b]-pyran-3-ol derivatives as potential anticonvulsant agents with a distinctive binding profile

Journal of Medicinal Chemistry

Volumn 39, Issue 23, 1996, Pages 4537-4539

  Chan, W N ^a   Evans, J M ^a   Hadley, M S ^a   Herdon, H J ^a   Jerman, J C ^a   Morgan, H K A ^a   Stean, T O ^a   Thompson, M ^a   Upton, N ^a   Vong, A K ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 FLUOROBENZAMIDO 3,4 DIHYDRO 2,2 DIMETHYL 2H BENZO[B]PYRAN 3 OL; ANTICONVULSIVE AGENT; APRIKALIM; BENZOPYRAN DERIVATIVE; CARABERSAT; DIAZEPAM; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; LEMAKALIM; PHENOBARBITAL; PHENYTOIN; PINACIDIL; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; MALE; MOUSE; NEUROPHARMACOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; SEIZURE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; BENZAMIDES; BENZOPYRANS; BINDING SITES; MICE; RADIOLIGAND ASSAY; RATS; STEREOISOMERISM; TRITIUM;

EID: 0029828946     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960535w     Document Type: Article

References (0)