Identification of a series of 1,2,3,4-tethydroisoquinolinylbenzamides with potential anticonvulsant activity

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 20, 1998, Pages 2903-2906

  Chan, Wai N ^a   Hadley, Michael S ^a   Harling, John D ^a   Herdon, Hugh J ^a   Jerman, Jeffrey C ^a   Orlek, Barry S ^a   Stean, Tania O ^a   Thompson, Mervyn ^a   Upton, Neil ^a   Ward, Robert W ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Anticonvulsant activity; Heterocyclic compounds; Molecular modelling; SB 204269 binding site

Indexed keywords

1,2,3,4 TETRAHYDROISOQUINOLINYL BENZAMIDE DERIVATIVE; ANTICONVULSIVE AGENT; BENZAMIDE DERIVATIVE; CARABERSAT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; FOREBRAIN; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SEIZURE THRESHOLD; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; BENZAMIDES; BENZOPYRANS; BINDING SITES; MICE; MODELS, MOLECULAR; QUINOLINES; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032552842     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00523-X     Document Type: Article

References (12)

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10. 50 values for vehicle-treated controls fell within the range of 12-14 mA.
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