Olfaction in Drosophila

Current Opinion in Neurobiology

Volumn 10, Issue 4, 2000, Pages 498-503

  Vosshall, Leslie B ^a  

^a B ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA; GENOME; MOLECULAR GENETICS; MULTIGENE FAMILY; NONHUMAN; OLFACTORY DISCRIMINATION; OLFACTORY RECEPTOR; OLFACTORY SYSTEM; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033867716     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(00)00111-2     Document Type: Review

References (65)

1. Hildebrand J.G. Analysis of chemical signals by nervous systems. Proc Natl Acad Sci USA. 92:1995;67-74.
2. ••].
3. th century.
4. Buck L., Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell. 65:1991;175-187.
5. ••].
6. ••]).
7. Gao Q., Chess A. Identification of candidate Drosophila olfactory receptors from genomic DNA sequence. Genomics. 60:1999;31-39.
8. Bargmann C.I. Neurobiology of the Caenorhabditis elegans genome. Science. 282:1998;2028-2033.
9. Mombaerts P. Seven-transmembrane proteins as odorant and chemosensory receptors. Science. 286:1999;707-711.
10. Sengupta P., Chou J.H., Bargmann C.I. odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl. Cell. 84:1996;899-909.
11. Touhara K., Sengoku S., Inaki K., Tsuboi A., Hirono J., Sato T., Sakano H., Haga T. Functional identification and reconstitution of an odorant receptor in single olfactory neurons. Proc Natl Acad Sci USA. 96:1999;4040-4045.
12. Zhao H., Ivic L., Otaki J.M., Hashimoto M., Mikoshiba K., Firestein S. Functional expression of a mammalian odorant receptor. Science. 279:1998;237-242.
13. Zhang Y., Chou J.H., Bradley J., Bargmann C.I., Zinn K. The Caenorhabditis elegans seven-transmembrane protein ODR-10 functions as an odorant receptor in mammalian cells. Proc Natl Acad Sci USA. 94:1997;12162-12167.
14. Krautwurst D., Yau K.W., Reed R.R. Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell. 95:1998;917-926.
15. Malnic B., Hirono J., Sato T., Buck L.B. Combinatorial receptor codes for odors. Cell. 96:1999;713-723. A technical tour-de-force that follows calcium imaging of dissociated olfactory neurons with single-cell PCR to isolate the neuron's OR. Not only do the results provide formal proof of the theory that a given ORN expresses only a single OR, but they also allow the association of an OR sequence with the odorants that interact functionally with that receptor. Multiple odorants are found to activate a single OR, and a given odorant activates multiple ORs.
16. Speca D.J., Lin D.M., Sorensen P.W., Isacoff E.Y., Ngai J., Dittman A.H. Functional identification of a goldfish odorant receptor. Neuron. 23:1999;487-498.
17. Stocker R.F. The organization of the chemosensory system in Drosophila melanogaster: a review. Cell Tissue Res. 275:1994;3-26.
18. Clyne P.J., Warr C.G., Carlson J.R. Candidate taste receptors in Drosophila. Science. 287:2000;1830-1834.
19. Hekmat-Scafe D.S., Steinbrecht R.A., Carlson J.R. Coexpression of two odorant-binding protein homologs in Drosophila: implications for olfactory coding. J Neurosci. 17:1997;1616-1624.
20. Park S-K., Shanbhag S.R., Wang Q., Hasan G., Steinbrecht R.A., Pikielny C.W. Expression patterns of two putative odorant-binding proteins in the olfactory organs of Drosophila have different implications for their functions. Cell Tissue Res. 300:2000;181-192.
21. Kim M.S., Repp A., Smith D.P. LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster. Genetics. 150:1998;711-721.
22. McKenna M.P., Hekmat-Scafe D.S., Gaines P., Carlson J.R. Putative Drosophila pheromone-binding proteins expressed in a subregion of the olfactory system. J Biol Chem. 269:1994;16340-16347.
23. Pikielny C.W., Hasan G., Rouyer F., Rosbash M. Members of a family of Drosophila putative odorant-binding proteins are expressed in different subsets of olfactory hairs. Neuron. 12:1994;35-49.
24. Robertson H.M., Martos R., Sears C.R., Todres E.Z., Walden K.K., Nardi J.B. Diversity of odourant binding proteins revealed by an expressed sequence tag project on male Manduca Sexta moth antennae. Insect Mol Biol. 8:1999;501-518.
25. Vogt R.G., Callahan F.E., Rogers M.E., Dickens J.C. Odorant binding protein diversity and distribution among the insect orders, as indicated by LAP, an OBP-related protein of the true bug Lygus lineolaris (Hemiptera, Heteroptera). Chem Senses. 24:1999;481-495.
26. Hekmat-Scafe D.S., Dorit R.L., Carlson J.R. Molecular evolution of odorant-binding protein genes OS-E and OS-F in Drosophila. Genetics. 155:2000;117-127.
27. Ache B.W. Towards a common strategy for transducing olfactory information. Semin Cell Biol. 5:1994;55-63.
28. Hildebrand J.G., Shepherd G.M. Mechanisms of olfactory discrimination: converging evidence for common principles across phyla. Annu Rev Neurosci. 20:1997;595-631.
29. Belluscio L., Gold G.H., Nemes A., Axel R. Mice deficient in G(olf) are anosmic. Neuron. 20:1998;69-81.
30. Brunet L.J., Gold G.H., Ngai J. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron. 17:1996;681-693.
31. Jansen G., Thijssen K.L., Werner P., van der Horst M., Hazendonk E., Plasterk R.H. The complete family of genes encoding G proteins of Caenorhabditis elegans. Nat Genet. 21:1999;414-419. In an impressive example of the power of genomics, these authors have scanned the completed C. elegans genome and assembled a complete list of all G proteins. They proceed to analyze the expression of 13 of these using reporter-fusion constructs, and find that many are expressed in sensory neurons. Mutations of four Gα subunits produce chemosensory defects, extending the work described in [32].
32. Roayaie K., Crump J.G., Sagasti A., Bargmann C.I. The G alpha protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons. Neuron. 20:1998;55-67.
33. Coburn C.M., Bargmann C.I. A putative cyclic nucleotide-gated channel is required for sensory development and function in C. elegans. Neuron. 17:1996;695-706.
34. Komatsu H., Mori I., Rhee J.S., Akaike N., Ohshima Y. Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron. 17:1996;707-718.
35. Colbert H.A., Smith T.L., Bargmann C.I. OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci. 17:1997;8259-8269.
36. + channel gene ether a go-go is required for the transduction of a subset of odorants in adult Drosophila melanogaster. J Neurosci. 18:1998;5603-5613.
37. Baumann A., Frings S., Godde M., Seifert R., Kaupp U.B. Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present in eyes and antennae. EMBO J. 13:1994;5040-5050.
38. Talluri S., Bhatt A., Smith D.P. Identification of a Drosophila G protein alpha subunit (dGq alpha-3) expressed in chemosensory cells and central neurons. Proc Natl Acad Sci USA. 92:1995;11475-11479.
39. 2+ channel in Drosophila. J Neurosci. 19:1999;4839-4846.
40. Marx T., Gisselmann G., Störtkuhl K.F., Hovemann B.T., Hatt H. Molecular cloning of a putative voltage- and cyclic nucleotide-gated ion channel present in the antennae and eyes of Drosophila melanogaster. Invert Neurosci. 4:1999;55-63.
41. Riesgo-Escovar J., Raha D., Carlson J.R. Requirement for a phospholipase C in odor response: overlap between olfaction and vision in Drosophila. Proc Natl Acad Sci USA. 92:1995;2864-2868.
42. Riesgo-Escovar J.R., Woodard C., Carlson J.R. Olfactory physiology in the Drosophila maxillary palp requires the visual system gene rdgB. J Comp Physiol [A]. 175:1994;687-693.
43. Deshpande M., Venkatesh K., Rodrigues V., Hasan G. The inositol 1,4,5-trisphosphate receptor is required for maintenance of olfactory adaptation in Drosophila antennae. J Neurobiol. 43:2000;282-288.
44. Dubin A.E., Harris G.L. Voltage-activated and odor-modulated conductances in olfactory neurons of Drosophila melanogaster. J Neurobiol. 32:1997;123-137.
45. Siddiqi O. Neurogenetics of olfaction in Drosophila melanogaster. Trends Genet. 3:1987;137-142.
46. Clyne P.J., Certel S.J., de Bruyne M., Zaslavsky L., Johnson W.A., Carlson J.R. The odor specificities of a subset of olfactory receptor neurons are governed by Acj6, a POU-domain transcription factor. Neuron. 22:1999;339-347. The authors describe the molecular characterization of the acj6 Drosophila mutant, first isolated because of its abnormal response in an assay that couples odorant application to a stereotyped startle response. acj6 is mapped to a previously described gene called I-POU, which encodes a POU-type homeodomain protein. Although the Acj6 protein is expressed in all ORNs, it is required for the expression of only a subset of DOR genes.
47. Clyne P., Grant A., O'Connell R., Carlson J.R. Odorant response of individual sensilla on the Drosophila antenna. Invert Neurosci. 3:1997;127-135.
48. de Bruyne M., Clyne P.J., Carlson J.R. Odor coding in a model olfactory organ: the Drosophila maxillary palp. J Neurosci. 19:1999;4520-4532. This paper uses single-unit extracellular recordings of single maxillary palp sensilla to define a total of six functional types of neuron in this olfactory organ. A diversity of electrophysiological responses is encountered that includes excitatory and inhibitory responses, with slow or fast recovery profiles, depending on the odorant applied.
49. Troemel E.R., Chou J.H., Dwyer N.D., Colbert H.A., Bargmann C.I. Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans. Cell. 83:1995;207-218.
50. Troemel E.R., Kimmel B.E., Bargmann C.I. Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C. elegans. Cell. 91:1997;161-169.
51. Ray K., Rodrigues V. Cellular events during development of the olfactory sense organs in Drosophila melanogaster. Dev Biol. 167:1995;426-438.
52. Reddy G.V., Gupta B., Ray K., Rodrigues V. Development of the Drosophila olfactory sense organs utilizes cell-cell interactions as well as lineage. Development. 124:1997;703-712.
53. Gupta B.P., Rodrigues V. Atonal is a proneural gene for a subset of olfactory sense organs in Drosophila. Genes Cells. 2:1997;225-233.
54. •].
55. •] describe a novel bHLH protein related to atonal that probably participates in patterning the olfactory sensory organs. Although an amos mutant is not available, misexpression studies demonstrate that amos has neurogenic activity in both the embryonic peripheral nervous system and adult olfactory organs.
56. Gupta B.P., Flores G.V., Banerjee U., Rodrigues V. Patterning an epidermal field: Drosophila lozenge, a member of the AML-1/Runt family of transcription factors, specifies olfactory sense organ type in a dose-dependent manner. Dev Biol. 203:1998;400-411.
57. Wang F., Nemes A., Mendelsohn M., Axel R. Odorant receptors govern the formation of a precise topographic map. Cell. 93:1998;47-60.
58. Laissue P.P., Reiter C., Hiesinger P.R., Halter S., Fischbach K.F., Stocker R.F. Three-dimensional reconstruction of the antennal lobe in Drosophila melanogaster. J Comp Neurol. 405:1999;543-552. The authors of this paper present a beautiful atlas of the antennal lobe in three dimensions that catalogues a total of 43 glomeruli. Laissue et al. use a new monoclonal antibody, nc82, to permit the visualization of all central neuropil in the fly brain and apply sophisticated software to render confocal microscope image-stacks into three-dimensional models.
59. Rubin B.D., Katz L.C. Optical imaging of odorant representations in the mammalian olfactory bulb. Neuron. 23:1999;499-511. This paper uses intrinsic signal imaging to visualize glomerular activation in response to a variety of odorants in the rat. Small numbers of bilaterally symmetric glomeruli are activated in response to a given odorant. As the concentration of applied odorant is increased, additional glomeruli are activated.
60. Joerges J., Küttner A., Galizia C.G., Menzel R. Representation of odours and odour mixtures visualized in the honeybee brain. Nature. 387:1997;285-288.
61. Laurent G. A systems perspective on early olfactory coding. Science. 286:1999;723-728.
62. Smith D.P. Olfactory mechanisms in Drosophila melanogaster. Curr Opin Neurobiol. 6:1996;500-505.
63. Krishnan B., Dryer S.E., Hardin P.E. Circadian rhythms in olfactory responses of Drosophila melanogaster. Nature. 400:1999;375-378. The authors demonstrate that olfactory sensitivity is increased during periods of subjective night. These rhythms of olfactory function persist in constant darkness and are sensitive to mutations that disrupt circadian rhythms of locomotor activity.
64. Hendricks J.C., Finn S.M., Panckeri K.A., Chavkin J., Williams J.A., Sehgal A., Pack A.I. Rest in Drosophila is a sleep-like state. Neuron. 25:2000;129-138.
65. Shaw P.J., Cirelli C., Greenspan R.J., Tononi G. Correlates of sleep and waking in Drosophila melanogaster. Science. 287:2000;1834-1837.