The K+ channel gene ether a go-go is required for the transduction of a subset of odorants in adult Drosophila melanogaster

Journal of Neuroscience

Volumn 18, Issue 15, 1998, Pages 5603-5613

  Dubin, Adrienne E ^a,b   Liles, Margaret M ^a   Harris, Greg L ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

^b Pharmaceutical Research Institute   (United States)

Author keywords

Ca2+; Cyclic nucleotide analogs; Drosophila; Eag; Electroantennogram; Ether a go go; Mutant; Olfaction; Potassium channel; Specific

Indexed keywords

2 BUTANONE; ACETIC ACID ETHYL ESTER; BUTYRIC ACID ETHYL ESTER; POTASSIUM CHANNEL; PROPIONIC ACID;

ARTICLE; BINDING SITE; CAENORHABDITIS ELEGANS; DENDRITIC CELL; DROSOPHILA MELANOGASTER; EXTRACELLULAR CALCIUM; GENE EXPRESSION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMELLING;

EID: 0032146259     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-15-05603.1998     Document Type: Article

References (36)

1. Ache B, Zhainazarov A (1995) Dual second-messenger pathways in olfactory transduction. Curr Opin Neurobiol 5:461-466.
2. Anholt R, Lyman R, Mackay T (1996) Effects of single P-element insertions on olfactory behavior in Drosophila melanogaster. Genetics 143:293-301.
3. Ayyub C, Paranjape J, Rodrigues V, Siddiqi O (1990) Genetics of olfactory behavior in Drosophila melanogaster. J Neurogenet 6:243-262.
4. Baumann A, Frings S, Godde M, Seifert R, Kaupp U (1994) Primary structure and functional expression of a Drosophila cyclic nucleotidegated channel present in eyes and antennae. EMBO J 13:5040-5050.
5. Breer H, Boekhoff I, Tareilus E (1990) Rapid kinetics of second messenger formation in olfactory transduction. Nature 345:65-68.
6. + and Ca2+ and modulated by cAMP. Nature 365:445-448.
7. Brunei L, Gold G, Ngai J (1996) General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron 17:681-693.
8. Buck L (1996) Information coding in the vertebrate olfactory system. Annu Rev Neurosci 19:517-544.
9. Buck L, Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65:175-187.
10. Budnik V, Zhong Y, Wu C (1990) Morphological plasticity of motor axons in Drosophila mutants with altered excitability. J Neurosci 10:3754-3768.
11. + channel subunits from Shaker and eag families in Xenopus oocytes. Neuron 17:535-542.
12. Coburn C, Bargmann C (1996) A putative cyclic nucleotide-gated channel is required for sensory development and function in C. elegans. Neuron 17:695-706.
13. Davis R (1996) Physiology and biochemistry of Drosophila learning mutants. Physiol Rev 76:299-317.
14. Dionne V, Dubin A (1994) Transduction diversity of olfaction. J Exp Biol 194:1-21.
15. Domatsu H, Mori I, Rhee J-S, Akaike N, Ohshima Y (1996) Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron 17:707-718.
16. Drysdale R, Warmke J, Kreber R, Ganetzky B (1991) Molecular characterization of eag: a gene affecting potassium channels in Drosophila melanogaster. Genetics 127:497-505.
17. Dubin A, Harris G (1997) Voltage-activated and odor-modulated conductances in olfactory neurons of Drosophila melanogaster. J Neurobiol 32:123-137.
18. Dubin A, Heald N, Cleveland B, Carlson J, Harris G (1995) Scutoid mutation of Drosophila melanogaster olfactory responses to short-chain acetate esters and ketones. J Neurobiol 28:214-233.
19. Farbman A (1994) Developmental biology of olfactory sensory neurons. Semin Cell Biol 5:3-10.
20. Firestein S, Darrow B, Shepherd G (1991) Activation of the sensory current in salamander olfactory receptor neurons depends on a G-protein-mediated cAMP second messenger system. Neuron 6:825-835.
21. Frings S, Lindemann B (1991) Current recording from sensory cilia of olfactory receptor cells in situ. I. The neuronal response to cyclic nucleotides. J Gen Physiol 97:1-16.
22. Frings S, Seifert R, Godde M, Kaupp U (1995) Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels. Neuron 15:169-179.
23. Ganetzky B, Wu C-F (1986) Neurogenetics of membrane excitability in Drosophila. Annu Rev Genet 20:13-44.
24. Guy H, Durell S, Warmke J, Drysdale R, Ganetzky B (1991) Similarities in amino acid sequences of Drosophila eag and cyclic nucleotide-gated channels. Science 254:730.
25. Halt H, Ache B (1994) Cyclic nucleotide- and inositol phosphate-gated ion channels in lobster olfactory receptor neurons. Proc Natl Acad Sci USA 91:6264-6268.
26. Helfand S, Carlson J (1989) Isolation and characterization of an olfactory mutant in Drosophila with a chemically specific defect. Proc Natl Acad Sci USA 86:2908-2912.
27. Hille B (1992) Ionic channels of excitable membranes. Sunderland, MA: Sinauer.
28. Jia X, Gorczyca M, Budnik V (1993) Ultrastructure of neuromuscular junctions in Drosophila: comparison of wild type and mutants with increased excitability. J Neurobiol 24:1025-1044.
29. Kaplan W, Trout W (1969) The behavior of four neurological mutants of Drosophila. Genetics 61:399-409.
30. Kleene S (1993) Origin of the chloride current in olfactory transduction. Neuron 11:123-132.
31. Kurahashi T, Yau K (1993) Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells. Nature 363:71-74.
32. Lindsley D, Zimm G (1992) The genome of Drosophila melanogaster. San Diego: Academic.
33. Lowe G, Gold G (1993) Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature 366:283-286.
34. Lynch J, Barry P (1989) Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor). Biophys J 55:755-768.
35. McClintock T, Ache B (1989) Histamine directly gates a chloride channel in lobster olfactory receptor neurons. Proc Natl Acad Sci USA 86:8137-8141.
36. Michel W, Ache B (1992) Cyclic nucleotides mediate an odor-evoked potassium conductance in lobster olfactory receptor cells. J Neurosci 12:3979-3984.