Selenoorganic compound, ebselen, inhibits nitric oxide and tumor necrosis factor-α production by the modulation of jun-n-terminal kinase and the NF-κb signaling pathway in rat Kupffer cells

Journal of Cellular Biochemistry

Volumn 78, Issue 4, 2000, Pages 595-606

  Shimohashi, Naoya ^a   Nakamuta, Makoto ^a   Uchimura, Koutaro ^a   Sugimoto, Rie ^a   Iwamoto, Hiroaki ^a   Enjoji, Munechika ^a   Nawata, Hajime ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

COX; Ebselen; JNK; Kupffer cells; NF B; Nitric oxide; Rat; TNF

Indexed keywords

EBSELEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; ORGANOSELENIUM DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; KUPFFER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION;

ANIMAL; ANTIOXIDANTS; AZOLES; BLOTTING, WESTERN; CELL NUCLEUS; CELLS, CULTURED; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT ANTIBODY TECHNIQUE; ISOENZYMES; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIVER; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC-OXIDE SYNTHASE; NITRITES; ORGANOSELENIUM COMPOUNDS; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE; PROSTAGLANDINS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TUMOR NECROSIS FACTOR;

EID: 0033866907     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4644(20000915)78:4<595::AID-JCB9>3.0.CO;2-B     Document Type: Article

References (56)

1. Function and activation of NF-κB in the immune system
2. A conserved signaling pathway: The Drosophila toll-dorsal pathway
3. Reactive oxygen intermediate-dependent NF-κB activation by interleukin-1b requires 5-lipoxygenase or NADPH oxidase activity
4. Stabilization of interleukin-2 mRNA by the c-jun NH2-terminal kinase pathway
5. N-acetyl-cystein and glutathione-dependent protective effects of PZ-51 (ebselen) against diquat-induced cytotoxicity in isolated hepatocytes
6. Studies on the anti-inflammatory activity of ebselen
7. Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells
8. A cytokine-responsive IkB kinase that activates the transcription factor NF-κB
9. Cloning two isoforms of rat cyclooxygenase: Differential regulation of their expression
10. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-α and lipopolysaccharide
11. Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis
12. Cloning and expression of inducible nitric oxide synthase from rat astrocytes
13. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
14. Anionic asmphiphile-independent activation of the phagocyte NADPH oxidase in a cell-free system by p47phox and p67phox, both in c-terminally trancated forms. Implication for regulatory Src homology 3 domain-mediated interaction
15. Preferential inhibition of inducible nitric oxide synthase by ebselen
16. Inhibitory effects of ebselen on lipid peroxidation in rat liver microsomes
17. Lipo-polysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrphages and blood monocytes
18. Prostaglandin synthase 2
19. Ebselen protects against ischemia-reperfusion injury in a canine model of myocardial infarction
20. Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: Mediation through both mitogen-activated protein kinase and NF-kappaB signaling pathway in macrophages
21. Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen
22. Effects of ebselen (PZ51) on ischemic brain oedema after focal ischemia in cats
23. Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2
24. Cloning and sequence analysis of the rat tumor necrosis factor encoding genes
25. Protein kinase cascades activated by stress and inflammatory cytokines
26. Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms
27. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
28. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide
29. Suppressive effects of all-trans retinoic acid on the lipopolysaccharide
30. Effects of retinoids on the production of tumour necrosis factor alpha and nitric oxide by lipopolysaccharide-stimulated rat Kupffer cells in vitro: Evidence for participation of retinoid X receptor signalling pathway
31. A novel biologically active seleno-organic compound - I
32. A novel biologically active seleno-organic compound - IV
33. Nuclear factor kappa B, a mediator of lipopolysaccharide effects
34. Selective activation and functional significance of p38α mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
35. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signaling pathway
36. Endotoxin, reticuloendothelial function, and liver injury
37. Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase
38. Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemic-reperfusion injury
39. A novel biologically active seleno-organic compound - III
40. Identification and characterization of an IκB kinase
41. A novel kinase cascade triggered by stress and heat shock that stimulates MAPK kinase-2 and phosphorylation of the small heat shock proteins
42. Messenger RNA degradation in eukaryotes
43. A novel biologically active seleno-organic compound - V
44. Transcriptional activation of the human TNF alpha promoter by superantigen in human monocytic cells: Role of NF-kappa B
45. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: Genomic complexity and molecular evolution of the gene
46. Protection by seleno-organic compound, ebselen, against acute gastric mucosal injury induced by ischemia-reperfusion in rats
47. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
48. Toward a better aspirin
49. Inhibition of superoxide and nitric oxide release and protection from reoxygenation injury by ebselen in rat Kupffer cells
50. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
51. A novel biologically active selenoorganic compound - VI
52. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
53. Toil-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
54. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
55. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
56. Bacterial lipopolysaccharide activates nuclear factor-κB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes