Endotracheal surfactant atomization: An alternative to bolus instillation?

Critical Care Medicine

Volumn 28, Issue 7, 2000, Pages 2540-2544

  Wagner, Mathias H ^b   Amthauer, Holger ^b   Sonntag, Josef ^b   Drenk, Franz ^a   Eichstädt, Hermann W ^b   Obladen, Michael ^b  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b NONE

Author keywords

Adult respiratory distress syndrome; Bolus instillation; Droplet size; Instillation method; Oxygenation; Recovery rate; Surfactant atomization; Surfactant distribution; Surfactant fog; Surfactant therapy

Indexed keywords

LUNG SURFACTANT EXTRACT; TECHNETIUM 99M;

ANIMAL EXPERIMENT; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD GAS; BLOOD PRESSURE; CONTROLLED STUDY; DRUG DISTRIBUTION; LUNG LAVAGE; NEBULIZATION; NONHUMAN; OXYGENATION; PARTICLE SIZE; PRIORITY JOURNAL; RABBIT; RESPIRATORY DISTRESS; RESPIRATORY FUNCTION; SCINTILLATION CAMERA;

EID: 0033865573     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200007000-00058     Document Type: Article

References (37)

1. 1. Halliday HL: Natural vs synthetic surfactants in neonatal respiratory distress syndrome. Drugs 1996; 51:226-237
2. 2. Soll RF: Appropriate surfactant usage in 1996. Eur J Pediatr 1996; 155:S8-S13
3. 3. Evans DA, Wilmott RW, Whitsett JA: Surfactant replacement therapy for adult respiratory distress syndrome in children. Pediatr Pulmonol 1996; 21:328-336
4. 4. Tashiro K, Yamada K, Li W, et al: Aerosolized and instilled surfactant therapies for acute lung injury caused by intratracheal endotoxin in rats. Crit Care Med 1996; 24: 488-494
5. 5. Serna D, Brenner M, Chen JC: A subject of ongoing investigation: Can exogenous surfactant be used to treat ARDS? Crit Care Med 1998; 26:1307-1308
6. 6. Warren WH: Is there a role for surfactant replacement therapy in adult pulmonary dysfunction? Crit Care Med 1998; 26:1626-1627
7. 7. Gregory TJ, Steinberg KP, Spragg R, et al: Bovine surfactant therapy for patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 1997; 155:1309-1315
8. 8. Nosaka S, Sakai T, Yonekura K, et al: Surfactant for adults with respiratory failure. Lancet 1990; 336:947-948
9. 9. Spragg RC, Gilliard N, Smith RM, et al: Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome. Chest 1994; 105:195-202
10. 10. Walmrath D, Günther A, Ghofrani HA, et al: Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome. Am J Respir Crit Care Med 1996; 154:57-62
11. 11. Anzueto A, Baughman RP, Guntupalli KK, et al: Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. N Engl J Med 1996; 334:1417-1421
12. 12. Weg JG, Balk RA, Tharatt S, et al: Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome. JAMA 1994; 272: 1433-1438
13. 13. Skov L, Bell A, Greisen G: Surfactant administration and the cerebral circulation. Biol Neonate 1992; 61:31-36
14. 14. Bell AH, Skov L, Lundstram KE, et al: Cerebral blood flow and plasma hypoxanthine in relation to surfactant treatment. Acta Paediatr 1994; 83:910-914
15. 15. Rey M, Segerer H, Kiessling C, et al: Surfactant bolus instillation: Effects of different doses on blood pressure and cerebral blood flow velocities. Biol Neonate 1994; 66:16-21
16. 16. Cowan F, Whitelaw A, Wertheim D, et al: Cerebral blood flow velocity changes after rapid administration of surfactant. Arch Dis Child 1991; 66:1105-1109
17. 17. Segerer H, van Gelder W, Angenent FWM, et al: Pulmonary distribution and efficacy of exogenous surfactant in lung-lavaged rabbits are influenced by the instillation technique. Pediatr Res 1993; 34:490-494
18. 18. Ueda T, Ikegami M, Rider ED, et al: Distribution of surfactant and ventilation in surfactant treated preterm lambs. J Appl Physiol 1994; 76:45-55
19. 19. Dijk PH, Heikamp A, Bambang Oetomo S: Surfactant nebulization: Lung function, surfactant distribution and pulmonary blood flow distribution in lung lavaged rabbits. Intensive Care Med 1997; 23:1070-1076
20. 20. Dijk PH, Heikamp A, Bambang Oetomo S: Surfactant nebulization prevents the adverse effects of surfactant therapy on blood pressure and cerebral blood flow in rabbits with severe respiratory failure. Intensive Care Med 1997; 23:1077-1081
21. 21. Lewis JF, Tabor B, Ikegami M, et al: Lung function and surfactant distribution in saline lavaged sheep given instilled vs. nebulized surfactant. J Appl Physiol 1993; 74: 1256-1264
22. 22. Li WZ, Chen WM, Kobayashi T: Aerosolized surfactant reverses respiratory failure in lung lavaged rats. Acta Anaesthesiol Scand 1994; 38:82-88
23. 23. Fok TF, Al-Essa M, Dolovich M, et al: Nebulization of surfactants in an animal model of neonatal respiratory distress. Arch Dis Child Fetal Neonatal Ed 1998; 78:F3-F9
24. 24. Lewis JF, Ikegami M, Higuchi R, et al: Nebulized vs. instilled exogenous surfactant in an adult lung injury model. J Appl Physiol 1991; 71:1270-1276
25. 25. Wagner MH, Segerer H, Koch H, et al: Circulatory changes after surfactant bolus instillation in lung-lavaged adult rabbits. Exp Lung Res 1996; 22:667-676
26. 26. Lachmann B, Robertson B, Vogel J: In vivo lung lavage as an experimental model of the respiratory distress syndrome. Acta Anaesthesiol Scand 1980; 24:231-236
27. 27. Segerer H, Scheid A, Wagner MH, et al: Rapid tracheal infusion of surfactant versus bolus instillation in rabbits: Effect on oxygenation, blood pressure and surfactant distribution. Biol Neonate 1996; 69:119-127
28. 28. Schermuly R, Schmehl T, Günther A, et al: Ultrasonic nebulization for efficient delivery of surfactant in a model of acute lung injury. Impact on gas exchange. Am J Respir Crit Care Med 1997; 156:445-453
29. 29. Lewis IF, Ikegami M, Jobe AH, et al: Aerosolized surfactant treatment of preterm lambs. J Appl Physiol 1991; 70:869-876
30. 30. Grothberg JB, Halpern D, Jensen OE: Interaction of exogenous and endogenous surfactant: spreading rate effects. J Appl Physiol 1995; 78:750-756
31. 31. Espinosa FF, Shapiro AH, Fredberg JJ, et al: Spreading of exogenous surfactant in an airway. J Appl Physiol 1993; 75:2028-2039
32. 32. Dijk PH, Heikamp A, Piers DA: Surfactant nebulization: Safety, efficiency and influence on surface lowering properties and biochemical composition. Intensive Care Med 1997; 23:456-462
33. 33. Thomas SHL, O'Doherty MJ, Page CJ, et al: Variability in the measurement of nebulized aerosol deposition in man. Clin Sci 1991; 81:767-775
34. 34. Arnon S, Grigg J, Nikander K, et al: Delivery of micronized budesonide suspension by metered dose inhaler and jet nebulizer into a neonatal ventilator circuit. Pediatr Pulmonol 1992; 13:172-175
35. 35. Cameron D, Clay M, Silverman M: Evaluation of nebulizers for use in neonatal ventilator circuits. Crit Care Med 1990; 18:866-870
36. 36. Hellström-Westas L, Bell AH, Skov L, et al: Cerebroelectrical depression following surfactant treatment in preterm neonates. Pediatrics 1992; 89:643-647
37. 37. Moen A, Yu X-Q, Rootwelt T, et al: Acute effects on systemic and pulmonary hemodynamics of intratracheal instillation of porcine surfactant or saline in surfactant-depleted newborn piglets. Pediatr Res 1997; 41:486-492