Ultrasonic nebulization for efficient delivery of surfactant in a model of acute lung injury: Impact on gas exchange

American Journal of Respiratory and Critical Care Medicine

Volumn 156, Issue 2 I, 1997, Pages 445-453

  Schermuly, R ^a   Schmehl, T ^a   Gunther A ^a   Grimminger, F ^a   Seeger, W ^a   Walmrath, D ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LUNG SURFACTANT; SURFACTANT;

ANIMAL MODEL; ARTICLE; DRUG DELIVERY SYSTEM; GAS EXCHANGE; LUNG INJURY; LUNG LAVAGE; NEBULIZATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; TREATMENT OUTCOME; ULTRASOUND THERAPY;

EID: 0030743504     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.156.2.9609092     Document Type: Article

References (38)

1. Walmrath, D., T. Schneider, J. Pilch, F. Grimminger, and W. Seeger. 1993. Aerosolized prostacyclin reduces pulmonary artery pressure and improves gas exchange in the adult respiratory distress syndrome (ARDS). Lancet 342:961-962.
2. Rossaint, R., K. J. Falke, F. López, K. Slama, U. Pison, and W. M. Zapol. 1993. Inhaled nitric oxide for the adult respiratory distress syndrome. N. Engl. J. Med. 328:399-405.
3. Gregory, T. L., W. J. Longmore, M. A. Moxley, J. A. Whitsett, C. R. Reed, A. A. Fowler, L. D. Hudson, R. J. Maunder, C. Crim, and T. M. Hyers. 1991. Surfactant chemical composition and biophysical activity in acute respiratory disress syndrome. J. Clin. Invest. 88:1976-1981.
4. Günther, A., C. Siebert, R. Schmidt, S. Ziegler, F. Grimminger, M. Yabut, B. Temmesfeld, D. Walmrath, H. Morr, and W. Seeger. 1996. Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema. Am. J. Respir. Crit. Care Med. 153:176-184.
5. Lachmann, B. 1989. Animal models and clinical pilot studies of sufactant replacement in adult respiratory distress syndrome. Eur. Respir. J. Suppl. 3:98s-103s.
6. Loewen, G. M., B. A. Holm, L. Milanowski, L. Wild, R. H. Notter, and S. Matalon. 1989. Alveolar hyperoxic injury in rabbits receiving exogenous surfactant. J. Appl. Physiol. 66:1087-1092.
7. Lewis, J. F., M. Ikegami, R. Higuchi, A. H. Jobe, and D. Absolom. 1991. Nebulized vs. instilled exogenous surfactant in an adult injury model. J. Appl. Physiol. 71:1270-1276.
8. Lewis, J. F., and L. A. McCaig. 1993. Aerosolized versus instilled exogenous surfactant in a nonuniform pattern of lung injury. Am. Rev. Respir. Dis. 148:1187-1193.
9. Lewis, J. F., B. Tabor, M. Ikegami, A. H. Jobe, M. Joseph, and D. Absolom. 1993. Lung function and surfactant distribution in saline-lavaged sheep given instilled vs. nebulized surfactant. J. Appl. Physiol. 74: 1256-1264.
10. Lewis, J., J. Goffin, P. Yue, L. A. McCaig, D. Bjarneson, and R. A. W. Veldhuizen. 1996. Evaluation of exogenous surfactant treatment strategies in an adult model of acute lung injury. J. Appl. Physiol. 80:1156-1164.
11. Walmrath, D., A. Günther, H. A. Ghofrani, R. Schermuly, T. Schneider, F. Grimminger, and W. Seeger. 1996. Bronchoscopic surfactant administration in severe adult respiratory distress syndrome (ARDS). Am. J. Respir. Crit. Care Med. 154:57-62.
12. Gregory, T. J., J. E. Gadek, J. E. Weiland, T. M. Hyers, C. Crim, L. D. Hudson, K. P. Steinberg, R. A. Maunder, R. G. Spragg, R. M. Smith, D. F. Tierney, B. Gipe, W. J. Longmore, and M. A. Moxley. 1994. Survanta® supplementation in patients with acute respiratory distress syndrome (ARDS) (abstract). Am. J. Respir. Crit. Care Med. 149:A567.
13. Anzueto, A., R. P. Baughman, K. K. Guntupalli, J. G. Weg, H. P. Wiedemann, A. A. Raventos, F. Lemaire, W. Long, D. S. Zaccardelli, and E. N. Pattishall. 1996. Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. N. Engl. J. Med. 334:1417-1421.
14. Seeger, W., D. Walmrath, F. Grimminger, S. Rosseau, H. Schütte, H. J. Krämer, L. Ermert, and L. Kiss. 1994. Adult respiratory distress syndrome: model systems using isolated perfused rabbit lungs. Methods Enzymol. 233:549-584.
15. Wagner, P. D., H. A. Saltzman, and J. B. West. 1974. Measurement of continuous distributions of ventilation-perfusion ratios: theory. J. Appl. Physiol. 36:588-599.
16. Walmrath, D., R. König, C. Ernst, H. Brückner, F. Grimminger, and W. Seeger. 1992. Ventilation-perfusion relationships in isolated blood-free perfused rabbit lungs. J. Appl. Physiol. 72:374-382.
17. Wagner, P. D., and J. B. West. 1980. Ventilation-perfusion relationships. In J. B. West, editor. Pulmonary Gas Exchange. Academic Press, New York. 233-235.
18. Krämer, H.-J., R. Schmidt, A. Günther, Y. Suzuki, and W. Seeger. 1995. Quantification of surfactant-protein B by enzyme-linked immunosorbent assay (ELISA). Am. J. Respir. Crit. Care Med. 152:1540-1544.
19. Schmehl, T., J. Gebhardt, H. Schütte, A. Scharmann, and W. Seeger. 1996. On-line laser-photometric monitoring of aerosol deposition in ventilated rabbit lungs. J. Appl. Physiol. 80:351-356.
20. Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:911-917.
21. Rouser, G., S. Fleischer, and A. Yamamoto. 1969. Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 5:494-496.
22. Seeger, W., C. Grube, A. Günther, and R. Schmidt. 1993. Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant preparations. Eur. Respir. J. 6:971-977.
23. Berry, D., M. Ikegami, and A. Jobe. 1986. Respiratory distress and surfactant inhibition following vagatomy in rabbits. J. Appl. Physiol. 61: 1741-1748.
24. Lewis, J. F., M. Ikegami, and A. H. Jobe. 1990. Altered surfactant function and metabolism in rabbits with acute lung injury. J. Appl. Physiol. 69: 2303-2310.
25. Walmrath, D., T. Schneider, R. Schermuly, H. Olschewski, F. Grimminger, and W. Seeger. 1996. Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 153:991-996.
26. Bredenberg, C. E., A. M. Paskanik, and G. F. Niemann. 1983. High surface tension pulmonary edema. J. Surg. Res. 34:515-523.
27. Wang, C. Z., R. E. Barrow, C. S. Cox, S. F. Yang, and D. N. Herndon. 1993. Influence of detergent aerosol on lung microvascular permeability. J. Appl. Physiol. 74:1016-1023.
28. 99m-DTPA-albumin in rabbits with surfactant dysfunction and lung injury. Clin. Physiol. 12:587.
29. Lee, O., O. Ueno, P. D. Wagner, and J. B. West. 1989. Pulmonary gas exchange after multiple airway occclusion by beads in the dog. Am. Rev. Respir. Dis. 140:1216-1221.
30. Wagner, P. D., D. R. Dantzker, V. E. Iacovoni, W. C. Tomlin, and J. B. West. 1978. Ventilation-perfusion inequality in asymptomatic asthma. Am. Rev. Respir. Dis. 118:511-517.
31. Lagerstrand, L., M. Dahlbäck, and G. Hedenstierna. 1992. Gas exchange during simulated airway secretion in the anesthetized rabbit. Eur. Respir. J. 5:1215-1222.
32. Ueda, T., M. Ikegami, E. D. Rider, and A. H. Jobe. 1994. Distribution of surfactant and ventilation in surfactant-treated preterm lambs. J. Appl. Physiol. 76:45-55.
33. Henry, M. D., C. M. Rebello, M. Ikegami, A. H. Jobe, E. G. Langenback, and J. M. Davis. 1996. Ultrasonic nebulized in comparison with instilled surfactant treatment of preterm lambs. Am. J. Respir. Crit. Care Med. 154:366-375.
34. Ellyett, K. M., R. S. Broadbent, E. R. Fawcett, and A. J. Cambell. 1996. Surfactant aerosol treatment of respiratory distress syndrome in the spontaneously breathing premature rabbit. Pediatr. Res. 39:953-957.
35. Huang, Y. T., S. P. Caminiti, T. A. Fawcett, R. E. Moon, P. J. Fracia, F. J. Miller, S. L. Young, and C. A. Piantadosi. 1994. Natural surfactant and hyperoxic lung injury in primates. I. Physiology and biochemistry. J. Appl. Physiol. 76:991-1001.
36. Schlesinger, R. B. 1985. Comparative deposition of inhaled aerosols in experimental animals and humans: a review. J. Toxicol. Environ. Health 15:197-214.
37. Morrow, P. E. 1974. Aerosol characterization and deposition. Am. Rev. Respir. Dis. 110:88-97.
38. Ashton, M. R., A. D. Postle, M. A. Hall, N. C. Austin, D. E. Smith, and I. C. Normand. 1992. Turnover of exogenous artificial surfactant. Arch. Dis. Child 67:383-387.